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CLASS: Sympathomimetic
Description: Epinephrine is a naturally occurring catecholamine that increases heart rate, cardiac contractile force, myocardial electrical activity, systemic vascular resistance, through bronchial artery constriction can reduce pulmonary congestion
Onset/Duration: Depends on route; 3-5 minutes
Beta 1 Sympathetic actions May restore electrical activity in asystole, Increase myocardial contractility, Lowers threshold for defibrillation
Beta 2 sympathetic actions Acts as a bronchodilator
Alpha sympathetic actions Produces vasoconstriction improving coronary blood flow, Vasoconstriction help support blood pressure in anaphylactic shock
Indications for Cardiac Arrest: Includes: V-Fib, V-Tach without pulse, PEA, Asystole
Would use for Profound Bradycardia AFTER atropine in the adult patient
Indications for Acute Allergic Reactions Mild or severe anaphylactic reaction or bronchoconstriction(severe asthma) usually pediatric patient
Contraindications: Hypersensitivity to sympathomimetic amines/ During labor/ Narrow angle glaucoma/hypertension/coronary insufficiency hemorrhagic traumatic or cardiac shock
Adverse Reactions: Hypertension, tachycardia, arrhythmias, pulmonary edema, anxiety, restlessness, psychomotor agitation, nausea, headache, angina
Dosage/Route: Cardiac Arrest(PEA, Asystole, V-Fib, pulseless V-tach), 1mg of 1:10,000 solution IV every 3-5 minutes, 2 to 2 ½ times the amount if given down ETT
Anaphylactic Reaction Dosages: Mild: 0.3-0.5mg (1:1000) subcutaneous, Severe: 0.3-0.5mg 1:10,000) slow IV, Drip dosage: Mix 1mg in 500ml of D5W or NS 2mcg/ml; run at 1-2mcg/min; profound bradycardia (titrate to response 2-10mcg/min)
Drug interactions: potentiates other sympathomemetics and MAOI's; Deactivated by alkaline solutions(sodim bicarb, furosemide)
Created by: james.p