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HIV Drugz
Exam 3 211.
| Question | Answer |
|---|---|
| What is Abacavir (Ziagen)? | nucleoside reverse transcriptase inhibitor |
| With Abacavir what do you need to assess for? | flu like symptoms. (fever rash headache nausea sore throat fatigue and sob) these are hypersensitivity reactions to this drug. |
| what is combivir (zidovudine)? | nucleoside reverse transcriptase inhibitor. |
| what is combivir a combination of? and what kind of drug is it? | zidovudine and lamivudine nucleoside reverse transcriptase inhibitor drug |
| what kinds of food do you need to avoid eating with combivir? | fatty foods |
| When taking which reverse transcriptase drugs should you avoid operating heavy machinery? (2) These drugs cause dizziness. | combivir, zidovudine |
| when taking which nucleoside reverse transcriptase inhbitor drugs should you monitor cbc, hepatic and renal function? | Zidovudine, combivir |
| which nucleoside reverse transcriptase drugs suppresses bone marrow function? (2) | Zidovudine, combivir |
| which nucleoside reverse transcriptase drugs can cause pancreatitis? (5) | combivir, emtricitabine, lamivudine, trizivir, truvada |
| what is didanosine(ddl, videx) and what inhibits the absorption? | nucleoside reverse transcriptase inhibitor, food inhibits absorption. take on empty stomach |
| what is emtricitabine (emtriva)? | nucleoside reverse transcriptase inhibitor |
| what do you need to teach the pt to avoid doing while taking emtricitabine? | eating fatty foods. |
| what is lamivudine? | nucleoside reverse transcriptase inhibitor |
| what do you need to teach the pt to avoid doing while taking lamivudine? | eating fatty foods. |
| what is stravudine (d4t, zerit) | nucleoside reverse transcriptase inhibitor |
| what is it important to assess with stravudine? (4) Hint: think S for senses | vision, hearing, touch and balance |
| when taking stravudine what does it induce? and this leads to what complications? | peripheral neuropathy leads to orthostatic hypotension reduced touch sensation decreased balance |
| what is it important to teach the pt who is taking stravudine? | change positions slowly, watch the floor or ground when walking |
| what is tenofovir (Viread)? | nucleoside reverse transcriptase inhibitor |
| what is it important to teach the pt who is taking tenofovir? | if this pt is also prescribed didanosine they need to separate the drugs by 2 hours. |
| what is trizir a combination of? and what kind of drug is it? | zidovudine, lamivudine,abacavir nucleoside reverse transcriptase inhibitor |
| what is epzicom and what is it a combination of? | nucleoside reverse transcriptase inhibitor abacavir, lamivudine |
| what is truvada? and what is it a combination of? | nucleoside reverse transcriptase inhibitor tenofovir and emtricitabine |
| what two things do you need to teach the pt who is taking truvada? | do not eat fatty foods and if taking didanosine separate these drugs by 2 hours. |
| what is zidovudine(retrovir) | nucleoside reverse transcriptase inhibitor |
| what do you need to teach the pt who is taking zidovudine? | do not operate heavy machinery do not drive! |
| what do you need to monitor with zidovudine? | cbc, hepatic and renal function |
| what is the difference between a nucleoside rti and a non nucleoside rti? | the nrti incorporates into the viral dna and halts the virals growth. the nnrti inhibit its movement |
| what is delvirdine (Rescriptor) | nnrti |
| what inhibits the absorption of delvirdine? | antacids. take 1 hour b4 or 2 after antacids |
| what is etravine? | nnrti |
| what classification of drugs interact with etravine? | protease inhibitors |
| what is efavirenz? | nnrti |
| what do you need to warn the pt about when taking efavirenz? (3) | dizziness, insomnia, and nightmares. |
| what is nevirapine (Viramune)? | nnrti |
| when taking nevirapine when should the pt stop taking this drug? and what should they report to the hcp? | if a rash develops persistent abdominal pain(drug may induce liver problems) |
| what do protease inhibitors do? | prevent viral replication and release of viral particles. active proteins are not produced so viral particles cannot leave the cell to infect other cells. |
| which classification of drugs supresses viral replication but does not actually kill the virus? | nnrti |
| which classification of drugs forms a counterfeit nucleotide base? | nrti |
| what is atazanavir(reyataz)? | protease inhibitor |
| what should you teach the pt who takes atazanavir? | take drug with food |
| why would a person taking atazanavir check his or her skin? and what would they find abnormal? | drug increases blood bilirubin levels. yellowish skin and sclera |
| what is fosamprenavir (Lexiva)? | protease inhibitor |
| what would you monitor with fosamprenavir? and why is this? | serum lipid levels and blood pressure drug can induce hyperlidemia and atherosclerosis. |
| what is indinavir (crixivan)? | protease inhibitor |
| what three things would you teach a pt who is taking indinavir? | take this drug on an empty stomach teach the pt to check his/her skin for yellowish presence teach pt to report flank pain |
| when taking which drug might i have a side effect of bloody urine? | indinavir protease inhibitor ( drug induces kidney stones) |
| what is kaletra(lopinavir + ritonavir)? | protease inhibitor |
| when a pt is allergic to what might they have a reaction to kaletra? | drugs containing sulfa |
| what would you teach a pt taking kaletra? | take on an empty stomach |
| what is nelfinavir (viracept)? | protease inhibitor |
| what do you monitor with nelfinavir and what side effect does this drug cause? | blood glucose diarrhea |
| when taking nelfinavir what can you do to reduce diarrhea episodes? | take with food |
| what is ritonavir (norvir)? | protease inhibitor |
| what do you want to teach the pt who is taking ritonavir? | take this drug with food to reduce gi side effects |
| what is saquinavir?(Invirase) | protease inhibitor |
| what do you want to teach the pt who takes saquinavir? Hint: think saq! sack of...! | take with a high fat or high calorie meal |
| what drug is absorbed best with a high fatty food? | saquinavir! |
| what do you warn the pt of when taking saquinavir? | avoid direct sunlight, wear protective clothing when outside and use sunscreen |
| what is a fusion inhibitor? | blocks hiv from fusing with a host cell. |
| what is enfurvitide (Fuzeon)? | fusion inhibitor |
| what form of drug does enfurvitide come in? and what do you need to teach pt? | subq injection rotate sites |
| what is an entry inhibitor? | blocks receptor ccr5 on cd4 t cells. |
| what is the name of the only entry inhibitor? | maraviroc(selzentry) |
| what do you want to teach the pt who is taking maraviroc? | if taking antihypertensive drugs severe hypotension is possible. |
| what do you want to monitor with maraviroc? | lfts |
| what is an intergrase inhibitor? | keeps viral dna from being inserted into host cells dna |
| what is the name of the only integrase inhibitor? | raltegravir(Isentress) |
| what is the common side effect of the integrase inhibitor | diarrhea |
| what is trimethoprim/sulfamethoxazole (septra)used for? | treatment of choice for pcp p.jiroveci penumonia |
| what is pentam? | iv or im treats pcp |
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