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vascular
diseases
| Question | Answer |
|---|---|
| Chylomicrons are derived from where? | diet-derived triglycerides |
| Are chylomicrons absent during fasting | yes |
| Where are VLDL derived | Liver-derived triglyceride |
| What does LDL transport | cholesterol |
| How do you calculate LDL | LDL = CH-HDL-TG/5 |
| Is fasting required to measure serum cholesterol | No: CH content in chylomicrons is <3%; hence, fasting does not have a medically significant effect on the serum level. |
| What is the source of apolipoproteins | HDL |
| What is HDL's function | removes cholesterol from plaques for disposal in the liver |
| Type II hyperlipoproteinmia dysfunction | increase LDL due to decrease LDL receptors |
| Type I dysfunction | hyperchylomicronemia decreased CPL or decreased apoCII |
| Type I inheritances | Autosomal recessive, rare childhood dz |
| Type I clinical findings | increased Chylomicrons; |
| What clinical syndromes is atherosclerosis associated with. | Ischemic heart dz cerebrovascular dz aortic aneurysms peripheral vascular dz nephroangiosclerosis (HTN - |
| Risk factors for atherosclerosis | age greater than 35 in males or 55 in women male gender family history of atherosclerosis lipid-rich diet hypertension diabetes cigarette smoking |
| Kidney hamartoma, composed of blood vessels, muscle and mature adipose tissue | Angiomyolipoma |
| Angiomyolipoma is associated with what dz | Tuberous sclerosis |
| Liver angiosarcoma is associated /w exposure to what? | Polyvinyl chloride arsenic thorium dioxide |
| Type I hyperlipoproteinemia results in an increased level of what? | chylomicrons and triglycerides |
| Type II hyperlipoproteinemia results in an increased level of what? | LDL and cholesterol |
| Xanthomas of the Achilles tendon are specific for what disorder | Type II hyperlipoproteinemia |
| Type III hyperlipoproteinemia results in an increased level of what? | IDL, triglycerides and cholesterol |
| Type IV hyperlipoproteinemia results in an increased level of what? | very-low-density lipoproteins (VLDLs) and triglycerides |
| Type IV is caused by a genetic defect in? | lipoprotein lipase gene |
| Type V hyperlioporteinemia results in an increase in? | VLDL, chylomicrons, triglycerides and cholesterol |
| Hyperlipidemia may be primary genetic defect or secondary to another disorder; such as: | diabetes mellitus alcoholism nephrotic syndrome hypothyroidism |
Created by:
schrla
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