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HY Biochem Vitamins

Day 14

QuestionAnswer
A pt presents with convulsions and irritability. What vitamin deficiency is causing these symptoms in this patient? B6
Which vitamin deficiency results in gum bleeding, bruising, anemia, and poor wound healing? Scurvy (vit C deficiency)
Vitamin C is necessary for the hydroxylation of which amino acids in collagen synthesis? Proline and lysine
What vitamin in ecxcess can cause hypercalcemia? vit D (also vit A)
What vitamins have a function similar to reduced glutathione? vit A, C, E
An alcoholic develops a rash, diarrhea, and altered mental status. What is the vitamin deficiency? B3/niacin
What vitamin deficiency matches the following description?: increased RBC fragility E
What vitamin deficiency matches the following description?: dermatitis, cheilosis, glossitis B2, B3, B12, folate, iron
What vitamin deficiency matches the following description?: peripheral neuropathy, angular chilosis, glossitis B12
What vitamin deficiency matches the following description?: hemorrhagic disease vit K
What vitamin deficiency matches the following description?: neural tube defects folic acid
What vitamin deficiency matches the following description?: dermatitis, diarrhea, dementia B3/niacin
What vitamin deficiency matches the following description?: megaloblastic anemia B12 or folate
What vitamin deficiency matches the following description?: pernicious anemia B12
What vitamin deficiency matches the following description?: night blindness, Bitot's spots, keratomalacia, xerophthalmia vit A
What vitamin deficiency matches the following description?: osteomalacia vit D
What vitamin deficiency matches the following description?: rickets vit D
Which vitamin matches the following statement: can be used to treat acne and psoriasis A (vitamin D treats psoriasis only, not acne)
Which vitamin matches the following statement: used in oxidation/reduction reactions B2/riboflavin and B3/niacin
Which vitamin matches the following statement: used in carboxylation reactions biotin
Which vitamin matches the following statement: involved in the hydroxylation of prolyl residues vit C
Which vitamin matches the following statement: requires intrinsic factor for absorption B12
Which vitamin matches the following statement: deficiency may result from kidney disease vit D
Which vitamin matches the following statement: used by pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase B1, B2, B3, B5, and lipoic acid
Which vitamin matches the following statement: given prophylactically to newborns to prevent hemorrhagic disease of newborn vit K
Which vitamin matches the following statement: can be used to elevate HDL and lower LDL B3/niacin
Which vitamin matches the following statement: deficiency can be caused by isoniazid use B6
Which vitamin matches the following statement: Cobalt is found within this vitamin B12 (cobalamin)
Which vitamin matches the following statement: critical for DNA synthesis folate/B12
What are the symptoms of zinc deficiency? poor wound healing
WHat enzyme is inhibited by the drug fomepizole? alcohol dehydrogenase
What is the difference between kwashiorkor and marasmus? Kwashiorkor is protein malnutrition with edema, swollen belly, anemia, and fatty liver. Marasmus is energy malnutritio with tissue and m wasting, loss of subq fat, and variable edema.
What vitamins should vegetarians supplement in their diet? B12
What are the symptoms of vitamin A toxicity? HA, n/v, stupor, dry skin, hepatomegaly, bone/joint pain, and increase in intracranial pressure
What vitamin am I? retinol, retinal Vit A
What vitamin am I? thiamine B1
What vitamin am I? pantothenic acid B5 (think of pantene pro-V shampoo)
What vitamin am I? niacin B3
What vitamin am I? ascorbic acid vit C
What vitamin am I? pyridoxine B6
What vitamin am I? alpha-tocopherol vit E
What vitamin am I? folic acid B9 (seriously? i've never heard this one...)
What vitamin am I? cobalamin B12
What vitamin am I? riboflavin B2
What is the MC vitamin deficiency in the US? Folic deficiency
What is the functionally active form of thiamine (B1)? TPP
How is thiamine deficiency diagnosed? By an increase in erythrocyte transketolase activity observed upon addition of thiamine.
What characterizes dry beriberi? Nonspecific peripheral neuropathy; toe, wrist, and foot drop; and m weakness, hyporeflexia, and areflexia
What characterizes wet beriberi? High output heart failure, peripheral edema, cardiomegaly, peripheral vasodilation
What are the two biologically active forms of ribloflavin (B2)? What is the role of these molecules? FMN, FAD. Both cofactors for oxidation-reduction reactions.
What are the biologically active forms of niacin (B3)? What is the role of these molecules? NAD+, NADP+. Both are cofactors for oxidation-reduction rxns.
Which amino acid is req'd for the generation of niacin? Tryptophan
What disease is caused by niacin deficiency? What are the symptoms of this disease? Pellagra. Diarrhea, dementia, dermatitis (and possibly death).
Why might pellagra be seen in a population that eats primarily corn B/c corn has no tryptophan and tryptophan can be metabolized to form niacin.
What is the biologically active form of B6? Pyridoxal phosphate
________ is a conenzyme for numerous enzymes including thos of amino acid metabolism (transaminations and deaminations). Pyridoxal phosphate (B6)
What drug can lead to a deficiency in B6 as well as B3? Isoniazid (TB drug)
What are the classic findings of a B6 deficiency? Convulsions, hyperirritability, and peripheral neuropathy
What is the biolgically active form of folic acid? tetrahydrofolate
Name 3 characteristics of folic acid deficiency. 1. Neural tube defects 2. Growth failure 3. Megaloblastic anemia
What type of reactions does biotin participate in? Carboxylation rxns (buy a tin of CO2)
Overconsumption of what food is linked to biotin deficiency? Egg whites which contain avidin. Avidin prevents absorption of biotin.
True or false: Lack of vitamin A in pregnant women has the potential for causing congenital malformations. False! Excess vitamin A acts as a teratogen (think of accutane).
What vitamin is associated with an increased risk of lung cancer in smokers? Vit A
What is vitamin D deficiency called in adults? in kids? Adults= osteomalacia. Kids= rickets.
For what protein synthesis is vitamin K dependent upon? Proteins C and S, prothrombin, and clotting factors 2, 7, 9, and 10
Created by: sarah3148