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Classic Labs/Finding

USMLE Rapid Review Pathology Classic Labs/Findings

AntiCentromere antibodies Scleroderma (CREST)
Antidesmoglein (epithelial) antibodies, blistering Pemphigus vulgaris
Anti-GBM Ab, glomerularnephritis and lung hemorrhage. Goodpasture's syndrome
Antihistone Antibodies Drug-induced SLE
Anti-IgG Antibodies (IgM against IgG), +RF, systemic inflammation, joint pannus, boutonniere deformity. Rheumatoid arthritis
Antimitochondrial antibodies (AMA's), female, cholestatsis, portal hypertension. Primary biliary cirrhosis
Antineutrophil cytoplasmic antibodies (ANCAs) Vasculitis (Wegener's: cANCA; Microscopic polyangiitis: pANCA; Pauci-immune crescentic glomerulonephritis: pANCA; Churg-Strauss: pANCA)
Antinuclear antibodies (ANAs: anti-Smith and Anti-dsDNA), type III hypersensitivity SLE
Antiplatelet antibodies, bleeding diathesis Idiopathic thrombocytopenic purpura (ITP)
Anti-topoisomerase antibodies Diffuse systemic scleroderma (not CREST)
Anti-transglutaminase/antigliadin antibodies, diarrhea, distention, weight loss, malabsorption, flattening of villi. Celiac disease
Azurophilic granular needles in leukemic blasts, seen in AML (especially the promyelocytic type) Auer rods
"Bamboo spine" on x-ray, chronic inflammation arthritis, HLA-B27 association, causes sacroiliitis, seronegative. Ankylosing spondilitis
Basophillic nuclear remnants in RBC's, due to splenectomy or nonfunctional spleen. Seen in patients with sickle cell, trauma, ITP, splenectomy (immunize these ppl). Howell-Jolly bodies
Basophillic stippling of RBC's Lead poisoning or sideroblastic anemia
Bloody tap on LP Subarachnoid hemorrhage: MCC is berry aneurysm, 2nd MCC is A-V malformation.
"Boot shaped" heart on x-ray Tetrology of Fallot, RVH
Branching gram +'ve rods with sulfur granules Actinomyces israelii
Bronchogenic apical lung tumor; can compress sympathetic ganglion and cause Horner's syndrome. Pancoast's tumor
"Brown" tumor of bone, cysts or hemorrhage into bone. Hemorrhage (hemosiderin) causes brown color of osteolytic cysts. Due to: 1. Hyperparathyroidism (takes Ca2+ from bone) 2. Osteitis fibrosis cystica (von Recklinghausen's disease of bone AKA NFT type I)
Cardiomegaly with apical atrophy, megacolon, megaesophagus. Chaga's disease caused by Trypanosoma cruzi
Cellular crescents in Bowman's capsule RPGN
"Chocolate cysts" of ovary, frequently bilateral. Also in peritoneum ("gun powder" stain in peritoneum) Endometriosis
Circular grouping of dark tumor cells surrounding pale nerofibrils. Associated with neuroblastoma, medduloblastoma, and Ewing's sarcoma. Homer Wright rosettes
Colonies of mucoid Pseudomonas in lungs, CFTR mutation in Caucasians resulting in fat-soluble vitamin deficiency and mucous plugs. Cystic Fribrosis
Degeneration of dorsal column nerves (cuneatus, gracilus) Tabes dorsalis (tertiary syphillis)
Depigmentation of neurons in substantia nigra. Decreased DA, decreased melanin. Basal ganglia disorder: rigidity (cogwheel), resting tremor, bradykinesia[paucity] ) Parkinson's disease
Desquamated epithelium casts in sputum. Seen in bronchial asthma ; can result in whorled mucous plugs. Curschmann's spirals
Disarrayed granulosa cells in eosinophillic fluid. Seen in granulosa-theca cell tumor of the ovary. Call-Exner bodies
Dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia. Finding in HPV: predisposes to cervical cancer (16, 18), perinuclear cytoplasmic clearing. Koilocytes
Enlarged cells with intranuclear inclusion bodies; Cowdry A Owl's eys appearance of CMV
Enlarged thyroid cells with ground-glass nuclei; papillary carcinoma of the thyroid. "Orphan Annie" eye nuclei
Eosinophilic cytoplasmic inclusion in liver cells; associated with alcoholic liver disease. Mallory bodies
Eosinophilic cytoplasmic inclusion in nerve cell. Seen in Parkinson's disease. Lewy body
Eosinophilic globule in liver. Seen in viral hepatitis, often yellow fever. Councilman body
Eosinophilic inclusion bodies in cytoplasm of hippocampal nerve cells Negri bodies of Rabies virus (Lyssavirus)
Extracellular amyloid deposition in gray matter of brain. Seen in Alzheimer's disease. Senile plaques
Giant B cells with bilobed nuclei with prominent inclusions (owl's eye). Seen with Hodgkin's lymphoma. Reed-Sturnberg cells
Glomerulus-like structure surrounding vessel in germ cells; Seen in yolk sac tumor. Schiller-Duval bodies
"Hair-on-end" (crew-cut) appearance on x-ray, marrow expansion Beta-thalassema, sicke cell anemia
hCG elevated Choriocarcinoma, hydatidiform mole (w/ w/out): precursor to choriocarcinoma.
Heart nodules (inflammatory). Seen with rheumatic fever. Focal myocardial inflammation with MNGC Aschoff bodies
Created by: jveulens