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Pharm 2

Antidotes and Common side effects

Acetaminophen N-acetylcysteine
Salicylates NaHCO3 (alkalinize urine) Dialysis
Amphetamines (basic) NH4Cl (acidify urine)
Acetylcholinesterase inhibitors, Organophosphates Atropine, pralidoxime
Antimuscarinics, anticholinergics Physostigmine salicylate
Beta blockers Glucagon
Digitalis Stop dig, normalize K+, lidocaine, Mg2+, anti-dig Fab fragments
Iron Deferoxamine
Lead CaEDTA, dimercaprol, succimer, penicillamine
Mercury, arsenic, gold Dimercaptrol, succimer
Copper, arsenic, gold penicillamine
Cyanide Nitrate, hydroxocobalamin,thiosulfate
Methemoglobin Methyline blue, Vit C
CO 100% O2, hyperbaric O2
Methanol, ethylene glycol ethanol, dialysis, fomepizole
Opioids Naloxone/naltrexone
Benzodiazepines Flumazenil
TCAs NaHCO3 (serum alkalinization)
Heparin Protamine sulfate
Warfarin Vit K, FFP
tPA, streptokinase Aminocaproic acid
Theophylline Beta blocker
Atropine-like SEs TCAs
Coronary vasospasm Cocaine, sumitriptan
Cutaneous flushing Vancomycin, Adenosine, Niacin, Ca blockers
Dilated cardiomyopathy Doxorubicin (Adriamycin), Daunorubicin
Torsades de pointes Class II AAs, Class IA AAs, cisapride
Agranulocytosis Clozapine, carbamazapine, colchicine, propylthiouracil, methimazole, dapsone
Aplastic anemia Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole
Direct Coombs-positive hemoyltic anemia Methyldopa
Gray baby syndrome Chloramphenicol
Hemolysis in G6PD deficient Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin
Megaloblastic anemia Phenytoin, MTX, Sulfa drugs
Thrombotic complications OCPs
Cough ACE inhibitors
Pulmonary fibrosis Bleomycin, Amiodarone, Busulfan
Acute cholestatic hepatitis Macrolides (Erythromycin)
Focal to massive hepatic necrosis Halothane, valproic acid, acetaminophen, Amantia phalloides
Hepatitis Isoniazid
Pseudomembranous colitis Clindamycin, ampicillin
Adrenocortical insufficiency Glucocorticoid w/d
Gynecomastia Spironolactone, Digitalis, Cimetidine, chronic Alcohol, Ketoconazole, estrogens Some Drugs Create Awesome Knockers
Hot flashes Tamoxifen, clomiphene
Hypothyroidism Lithium, amiodarone
Gingival hyperplasia Phenytoid
Gout Furosemide, thiazides
Osteoporosis Corticosteroids, heparin
Photosensitivity Sulfonamides, Amiodarone, Tetracycline
Rash Ethosuximide, lamotrigine, carbamazepine, phenobarbitol, phenytoid, sulfa drugs, penicillin, allopurinol
SLE-like symptoms Hydralazine, Isoniazid, Procainamide, Phenytoin
Tendonitis, Achilles rupture Fluroquinolones
Fanconi's syndrome Expired tetracyclines
Interstitial nephritis Methicillin, NSAIDs, furosemide
Hemorrhagic cystitis Cyclophosphamide, ifosfamide
Diabetes insipidus Lithium, demeclocycline
Parkinson-like syndrome Haloperidol, chlorpromazine, reserpine, metoclopramide
Seizures Bupropion, imipenem/cilastatin, isoniazid
Tardive dyskinesis Antipsychotics
Nephrotoxicity/Neurotoxicity Polymyxins
Nephrotoxicity/Ototoxicity Aminoglycosides, vancomycin, loop diuretics, cisplatin
Created by: zacharykr