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pharmacology

QuestionAnswer
memantine NMDA antagonist, prevent neural depolarisation, ca2+ increase, ROS and glutamate release. alzheimers
Rivastigmine Anti-ACHE alzheimers
levodopa dopamine precursor
carbidopa dopa decarboxylase
bromocriptine D2 agonist
entacapone catechol o methlyl transferase inhibitor
selegiline MAOB inhibitor
amandadine antiviral and increase dopamine
chloropromazine typical anti psychotic blocks D1,D2,muscarinic, histamine and alpha can cause parkinsonism
Haloperidol typical anti psychotic blocks D1,D2 can cause parkinsonism
sulpriride atypical antipsychotic, D2 selective
clozapine atypical antipsychotic blocks d4 stronger and D1and D2 atypical antipsychotic Blocks muscarinic/histamine receptor - sedation
aripiprazole atypical antipsychotic partial agonist at D2 and blocks 5HT2A ( prevent 5ht binding)
imipramine anti depressant non selective amine reuptake inhibitors (TCA) antimuscarinic , antihistamine side effects Never be used with MAOI ( cheese)
duloxetine anti depressant non selective 5HT/NE reuptake inhibitor less antimuscarinic less TCA
Fluoxetine (PROZAC) SSRI antidepressant less antimuscarinic and cardiotxic Never used with MAOI ( serotonin syndrome)
phenelzine non selective MAOI
moclobemide MAOA I
trazodone antidepressant blocks 5ht uptake and 5-HT2 receptors
buproprion antidepressant blocks NE and dopamine uptake
mirtazapine antidepressant blocks alpha2 and 5ht2 receptors
lithium moodstabilising drug for maniac
vigabatrin antiepiletic inhibit gaba transaminase
tiagabinE antiepiletic inhibit gaba reuptake
gabapentin ( l type) antiepiletic, voltage gated ca2+channel blocker
ethosuximide (t type) antiepiletic, voltage gated ca2+channel blocker
phenytoin antiepiletic, voltage gated Na+channel blocker
carbamazapine antiepiletic, voltage gated Na+channel blocker
valporate antiepiletic, Na+channel blocker blocks NMDA increase GABA availability
diazapem antiepiletic, benzodiazepene anxiolytic, hypnotic reduce REM and stage4 slow wave sleep relax muscle tone amnesia Side effect of tolerance and dependence
Zolpidem hypnotic act on benzodiazepene receptor reduce rem sleep, less reduction than BDZ on reduce slow wave sleep
phenobarbital barbituates anxiolytic , hypnotic increase GABAa channel open time supress excitatory neuronal activity depress cardiovascular, respiratory and CNS ( high dose die) reduce REM and slow wave sleep more than BDZ increased tolerance and dependence
buspirone anxiolytic partial 5HT1A agonist tachycardia, hypertension with MAOaI
thiopental intravenous anaesthesia barbituates respiratory depression, cerebral repression slow onset, slow recovery
propofol intravenous anaesthesia same effect as thiopental but fast onset
etomidate intravenous anaesthesia no analgesic little cardiovascular and respiratory depression fast onset produce involutary movements and post op vomitting
ketamine intravenous anaesthesia NMDA receptor anatagonsit dissociate anaesthesia cardiovascular stimulation increase cerebral blood flow and oxygen demand
nitrous oxide inhaled anaesthesia analgesic at low con but potency too low to reach surgical anaesthesia increase sympathetic stimulation
halothane inhaled anaesthesia increase parasympatheitc stimuatlion dysrhythmogenic liver toxicity
isoflurane increases heart rate, decrease blood pressure
morphine opoid
coedine opoid
fentanyl opoid
methadone opoid agonist opoid addiction treatment less euphoria than morphine
buprenorphine partial agonist at u receptors antagonist k receptors opoid addiction treatment
naloxone antagonist at all opoid receptors
Created by: mimimomo
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