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Cytokines Day 2

Day 2

QuestionAnswer
FEVER/ACUTE PHASE CYTOKINES/PYOGENS SECRETED BY MONOCYTES AND MACROPHAGES IL-1, IL-6, TNF-ALPHA
3 CHEMOTACTIC FACTORS FOR NEUTROPHILS IL-8, C5a, LEUKOTRIENE B4
INDUCES DIFFERENTIATION OF T CELLS INTO TH1 CELLS IL-12
ACTIVATES NK CELLS IL-12
MIEDATES SEPTIC SHOCK TNF-ALPHA
STIMULATES T CELLS (HELPER AND CYTOTOXIC) IL-2
STIMULATES BONE MARROW IL-3
STIMULATES IgE AND IgG IL-4
STIUMLATES IgA AND EOSINOPHILS IL-5
FUNCTIONS LIKE GM-CSF IL-3
INHIBITED BY CYCLOSPORINE AND TACROLIMUS (DRUGS) IL-2
ACTIVATES MACROPHAGES AND TH1 CELLS; SUPPRESSES TH2 CELLS IFN-GAMMA
INHIBITS ACTIONS OF ACTIVATED T CELLS AND TH1; SECRETED BY REGULATORY T CELLS IL-10
PLACES UNINFECTED CELLS IN AN ANTIVIRAL STATE BY INHIBITING VIRAL PROTEIN SYNTHESIS IFN ALPHA AND BETA (DEGRADES VIRAL mRNA)
PROMOTES B CELL GROWTH AND DIFFERENTIATION IL-4, IL-5
PRODUCED BY TH1 CELLS IL-2, IFN GAMMA
PRODUCED BY TH2 CELLS IL-4, IL-5, IL-10
which recombinant cytokine is used to treat hepatitis b and c, kaposi's sarcoma, leukemias, and malignant melanoma? alpha-interferon
which recombinant cytokine is used to treat MS? beta-interferon
which recombinant cytokine is used to treat chronic granulomatous disease? gamma-interferon
which two recombinant cytokines are used to treat thrombocytopenia? oprelvekin (IL-11), and thrombopoietin
which two recombinant cytokines are used to treat bone marrow loss in chemo? filagrastim (granulocyte colony stimulating factor) and sargramostim (granulocyte-macrophage colony stimulating factor)
which recombinant cytokine is used to treat anemias (esp in renal failure and chemo) erythropoietin (epoietin)
which recombinant cytokine is used to treat renal cell carcinoma and metastatic melanoma? aldesleukin (IL-2)
Created by: sarah3148