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Ig Isotypes + CD mar

Day 2 (IgG Isotypes and CD surface markers)

QuestionAnswer
what is the mechanism for isotpye switching? alternative splicing of mRNA; mediated by cytokines and CD40
most abundant Ab IgG
produced in primary (immediate) response to an antigen IgM
secreted as a dimer IgA
crosses placenta to provide infant with passive immunity IgG (Gift from mom)
found on surface of b cells and in serum, but f'n is unknown IgD
mediates immunity to worms by activating eosinophils IgE
mediates type 1 hypersensitivity IgE
most effective opsonin and neutralizes bacterial toxins and viruses IgG
Found in breast milk IgA
Prevents attachment of bacteria and viruses to mucous membranes, but does NOT fix complement IgA
pentamer that traps free antigen out of tissue while humoral response evolves IgM
the only Ig when class switching cannot occur IgM
used to detect an acute west nile virus infection IgM
initiates the classic complement pathway C1
deficiency of this complement enzyme leads to hereditary angioedema C1 esterase (causes increased bradykinin)
initiates the alternative complement pathway microbial surfaces (e.g., endotoxin)
deficiency of this complement component leads to recurrent infections with neisseria C5-C9
deficiency of C3 leads to what types of infections? for what type of hypersensitivity reaction is there an increased risk? Severe, recurrent pyogenic sinus and respiratory tract infections; increased susceptibility to type 3 hypersensitivity rxns
deficiency of what complement enzyme leads to complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria (PNH)? DAF (decay-accelerating factor)
cell surface proteins: T cells (general) TCR, CD3
cell surface proteins: Helper T cells CD4, CD40L
cell surface proteins: Cytotoxic T cells CD8
cell surface proteins: B cells CD 19, 20, 21 (receptor for EBV); MHC II; IgD AND IgG
cell surface proteins: macrophages MHC II, CD 14, CD16, CD40, Fc and C3b receptors
cell surface proteins: NK cells MHC I, CD16 (binds Fc of IgG), CD56 (unique marker for NK)
cell surface proteins: all cells except mature RBCs MHC I
cell surface proteins: WBC, RBC, and platelets (protect against complement-mediated damage) CD55, CD59
Name 4 exposures for which patients are given preformed antibodies (for passive immunity)? Tetanus toxin, Botulinum toxin, HBV, or Rabies virus (To Be Healed Rapidly)
Preemies born in winter months should be given which passive immunity vaccine every month? RSV
Created by: sarah3148