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GI Drugs - FA & DIT
Question | Answer |
---|---|
Rx for Acites | THiazide + loop diuretic, paracentesis |
Hepatic Encephalopathy Rx | Lactulose |
Rx for liver failure (cirhosis) | B-blocker, diuretics (thiazides, loops), vit K, lactulose (encephalopathy) |
Rx Crohn's disease | Corticosteroids, infliximab |
R ulcerative colitis | sulfasalazine, infliximab |
esophageal varices Rx | B-blocker (propranolol) |
Wilson's disease (sx & rx) | Rx: penicillamine Ataxia, Basal ganglia degeneration (parkinson sx), Corneal depositis (kayser-fleischer rings), Demenitia, hemolytic anemia |
Antacids that 1. cause diarrhea, 2. cause constipation. 3. cause rebound hypercalcemia. 4. hypokalemia | 1. Magnesium Hydroxide (diarrhea), Aluminum Hydroxide (constipation). 3. Calcium Carbonate (hypercalcemia). 4. Hypokalemia (all) |
MOA of proton pump inhibitors & 2 common | Irreversibly inhibit H+/K+ ATPase in stomach parietal cells. Omeprazole & lansoprazole |
Cimetidine MOA & SE | "DINE"= H2 blocker. for peptic ulcer, gastritis, mild esophageal reflux. P-450 inhibitor & gynecomastia, can cross BB barier (headaches, dizzy, confusion) |
Bismuth, sucralfate | binds ulcer base to protect. for ulcers, traveler's diarrhea & H.P |
Misoprostol - MOA & use | Prostoglandin analog --> Increase production & secretion of gastric mucous barrier, decrease acid. Use: prevent NSAID-induced peptic ulcers. Maintain patent ductus arteriosus. Induce labor |
Infliximab - MOA & use & SE | MOA: andibody to TNF Crohn's disease, RA SE: respiratory infection, fever, hypotension |
Sulfasalazine - use | Activated by colonic bacteria (only works on colon & terminal illeus. antibacterial & anti-infamatory use: UC & chohn's |
Ondansetron - MOA & use | 5-HT antagonist. Prevents vomiting SE: headache |
metoclopramide - MOA, use, SE | D2 receptor antagonist --> increased resting tone, motility, LES tone & contractility use: post-surgery gastroparesis SE: parkinsonian & decrease seizure threshold |