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Drugs!
Question | Answer |
---|---|
Prostaglandin E1 MOA | stim adenylyl cyclase, inc cAMP, relax VSM |
Prostaglandin E1 use | treat heart defects in infants, ED |
Milrinone MOA | PDE inhibitor, slows cAMP degradation |
Milrinone use | Treat Failure |
Nitroglycerine MOA | inc NO production- VSM relaxation |
Nitroglycerine use | Treat angina, CHF, MI |
Nitroglycerine adverse | Hypotension, contraindicated with viagra |
Furosemide class | Diuretic (loop diuretic)- most effective |
Furosemide use | hypertension, edema, CHF, renal failure symptoms |
Diuretic adverse Rxn | Electrolyte disturbance |
Acetazolamide | Diuretic (Carbonic Anhydrase Inhibitor) |
Acetazolamide use | Hypertension, edema, CHF, renal failure symptoms |
Hydrochlorothiazide class | Diuretic |
Hydrochlorothiazide use | hypertension, edema, CHF, renal failure symptoms |
Cardioactive antihypertensives | lower BP- Tx hypertension and heart failure |
Cardioactive antihypertensive drugs | B blockers, Ca channel blockers |
Isoproterenol | B1/B2 agonist |
B1 agonist action | inc. cAMP, activate Ca channels- Ca influx |
B2 agonist action | inc. cAMP, phospholamban activation, stim SERCA- Ca sequestration |
B1 agonist use | tx. cardiogenic shock, heart failure |
B2 agonist use | tx. asthma, emphysema |
Dopamine MOA | dose dependent |
low dose dopamine | dopamine receptor agonist |
high dose dompamine | conversion to NE- a-receptor agonist |
dopamine receptor agonist | vasodilation in renal system |
Methotrexate MOA | dihydrofolate reductase competitive inhibitor |
Methotrexate use | tx. cancer, autoimmune disease |
Digoxin class | cardiac glycoside |
Digoxin MOA | Inh. Na/Ca exchange (dec. Ca efflux), inh. Na/K ATPase (decreases gradient) |
Digoxin use | Tx. heart failure |
Digoxin adverse | dec. QT interva., inc. PR interval, ST depression |
Propranolol class | Non-Selective B-antag |
Propranolol use | Hypertension |
B-blocker adverse | dec. exercise tolerance, bradycardia, conduction probs in heart |
B-blocker contraindication | Heart failure |
Acebutolol | Cardioselective B1 with ISA |
Atenolol | Cardioselective B1 without ISA |
Propranolol | Non-cardioselective B1/B2 without ISA |
Pindolol | Non-cardioselective B1/B2 with ISA |
Norepinephrine | A1 receptor agonist |
Norepinephrine MOA | Gq activation- sm muscle contrxn |
Norepinephrine effect | vasoconstrictor |
Norepinephrine use | Tx. hypotension, nasal congestion |
Clonidine class | Sympatholytic |
Clonidine MOA | A2 agonist- inhibit vasomotor center in medulla oblongata, dec. symp activity |
Clonidine use | tx. hypertension |
Clonidine adverse | Can constrict coronaries (post-synaptic response) |
Prazosin class | A1 antagonist |
Prazosin MOA | Reduces NE/Epi binding, causing vasodilation |
Prazosin use | tx. hypertension |
Prazosin adverse | orthostatic hypertension |
Captopril | ACE Inhibitor |
Captopril MOA | Reduce Ang conversion, inhibit bradykinin degradation- vasodilation |
Captopril use | hypertension, CHF, MI |
Captopril adverse | Renal failure with art stenosis, bradykinin in lungs |
Losartan class | Ang II Receptor Blocker |
Losartan use | hypertension, CHF |
Losartan adverse | renal failure with art stenosis |
Nifedipine | Ca channel blocker |
Nifedipine use | hypertension, vasospastic angina, arrhythmia |
Nifedipine adverse | depress heart function |
Acetominophen MOA | Inhibits COX 1 and 2- increases pain threshold and reduces fever |
Acetominophen use | pain/fever |
Prednisone MOA | inhibits phospholipase A2, red. inflammation |
Prednisone use | inflammation, autoimmune disease |
Nitroglycerine class | nitrate vasodilator |
Nitrate MOA | inc. No production, inactivate MLCK- VSM relaxation |
Nitrate use | angina, CHF, MI |
Sumatriptan MOA | stim presynaptic receptors, inhibiting dural vasodilation and inflammation |
Sumatriptan uses | Migraines/headaches |
Nifedipine subclass | Dihydropyridine- Ca blocker |
Verapamil | Phenylalkylamine subclass of Ca blockers |
Verapamil | Affects heart more than BVs |
Verapamil | potent neg chronotrope, inotrope, and dromotrope |
Dilitiazem | Benzothiazepine subclass of Ca channel blockers |
Dilitiazem | affects heart and BVs |
Levosimendan | Ca Sensitizer |
Levosimendan MOA | Inc Sens of cardiac troponin to Ca |
Levosimendan MOA | Ca sens + PDE III inhibition- vasodilation |
Levosimendan use | Heart failure |
Levosimendan adverse | Hypotension and reflex tachycardia |
Isocarboxazid | MAOI- affects NE metabolism |
Isocarboxazid use | depression |
Tolcapone | COMT inhibitor- affects NE metabolism |
Tolcapone use | Parkinsons |
Mecamylamine | Nicotinic antagonist |
Mecamylamine | reduce BP |
Mecamylamine use | Surgical BP control |
Demecarium Ambenonium | Indirect cholinergic agonist (AChE inhibitor) |
Demecarium use | open angle glaucoma, myasthenia gravis |
Pilocarpine | Cholinomimetic- muscarinic agonist |
Pilocarpine use | ocular hypertension, open and closed angle glaucoma |
Tolterodine | Anticholinergic- muscarinic antagonist |
Tolterodine use | Overactive bladder |
Atropine | Anticholinergic- muscarinic antagonist |
Atropine use | reduce airway secretions during intubation |
Amphetamine | Affects NE release |
Amphetamine use | ADHD |
Desipramine | Affects NE Reuptake |
Desipramine use | depression |
Reserpine | Affects Vesicular packaging of NE |
Reserpine use | hypertension |
Metyrosine | affects NE synthesis |
Metyrosine use | tx pheocromacytoma |
B antagonist without ISA | full antagonists |
atenolol, metoprolol | B1 (cardioselective) antagonists |
Carvedilol, Labetolol, Nadolol, Propranolol | B1/B2 (noncardioselective) antagonist |
B-Antagonists with ISA | Act as partial agonists |
Acebutolol | Cardioselective B1 |
Penbutolol, Careolol, Pindolol | Non-cardioselective B1/B2 |
Terbutaline | B2 Agonist |
Terbutaline uses | asthma, emphysema (relaxes airways) |
Dobutamine | B1 agonist |
Dobutamine use | Tx. Cardiac decomposition |
Metoprolol | B1 antagonist |
Metoprolol use | tx. hypertension |
Yohimbine | A2 antagonist |
Yohimbine use | Tx ED (injection), produce miosis |
Phenylephrine | A1 agonist |
Phenylephrine use | tx. hypotension, congestion |
A1 receptor | high affinity for Epi |
A2 receptor | high affinity for epinephrine |
B1 receptor | high affinity for Isoproteronol |
B2 receptor | high affinity for Isoproteronol |
M2 Receptor signaling | Gi/G0- hyperpolarization and inhibition |
M3 Receptor signaling | Gq- depolarization and excitation |
B2 Receptor signaling | Gs- inc. adenylyl cyclase |
A1 Receptor signaling | Gq- depolarization and excitation, Gi/0- inc PLA2 |
B1 Receptor signaling | Gs- incl adenylyl cyclase |
A2 Receptor signaling | Gi- dec. adenylyl cyclase, G0- inh. Ca channels, inc PLC and PLA2 |