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DIT 2009 WK 12

Q&A from DIT emailed questions WK 12

Clinical findings in pt with lead poisoning Encephalopathy and erythrocyte basophilic stippling, abdominal colic, constipation, headaches, peripheral neuropathy (wrist/foot drop), sideroblastic anemia (mycrocytic, hypochromic)
Anticancer agent who's toxicity is increased by allopurinol 6-mercaptopurine
Anticancer agent that is cardiotoxic Doxorubicin (Adriamycin) and Daunorubicin
Anticancer agent that blocks polymerization of tubulin Vincristine and Vinblastine
Anticancer agent known to cause hemorragic cystitis Cyclophosphamide and Ifosfamide
Anticancer agent that crosses the blood-brain barrier (used for brain cancerrs) Nitrosureas
Side effects of Clonidine Dry mouth, sedation, severe rebound hypertension
Artery most often the culprit in an MI LAD > RCA > Circumflex
What is Exstrophy of the bladder Congenital gap in anterior bladder wall and abdominal wall in front of it – exposure of bladder inferior to outside world
Condition normally associated with exstrophy of the bladder Epispadias
Serotonin agonist used to treat migraine headaches Sumatriptan
Clinical uses of Ondansetron Control vomiting postoperatively and in pts undergoing cancer chemotherapy
What is Syringomyelia Enlargement of the central canal of the spinal cord. MC at C8-T1
Common symptoms seen in Syringomyelia Bilateral loss of pain and temperature sensation in upper extremities with preservation of touch sensation
Abnormality a/w with calf pseudohypertrophy Duchenne's
Abnormality a/w with Gower's maneuver Duchenne's
Abnormality a/w with tendon xanthomas Familial Hypercholesterolemia
Abnormality a/w with subluxation of the lenses Marfan's
Abnormality a/w with cafe-au-lait spots Alport's
Abnormality a/w with tuft of hair on lower back Neural tube defect - spina bifida occulta
Typical presentation of a pt with Hodgkin's disease Constitutional "B" signs/symptoms - low grade fever, night sweats, weight loss
Cancers a/w xeroderma pigmentosa Melanoma, basal cell carcinoma, and especially Squamous cell Carcinomas of skin
Cell types that do not require insulin for the uptake of glucose Brain and RBC's
Typical presentation of a pt with pancreatic insufficiency Malabsorption of fat and fat-soluble vitamins
Treatment for pancreatic insufficiency Limit fat intake, replace fat-sol vitamins, or ingest oral pancreatic lipase
Why is the murmur of Ao stenosis not heard during the first part of systole B/c the pressure still isn't large enough to open the stenotic valve
Potential metabolic fates of pyruvate Alanine, Oxaloacetate, Acetyl-CoA, Lactate, and Alcohol
Physical changes taking place during REM sleep Increase and variable pulse, penile/clitoral tumescence, variable blood pressures
Nerve that innervates the "glossus" muscles Hypoglossal Ne
Nerve that innervates the "palat" muscles Vagus Ne
Types of cancer/s are associated with chromosomal translocation (9;22) CML (bcr-abl hybrid)
Types of cancer/s are associated with chromosomal translocation (8;14) Burkitt's lymphoma (c-myc activation)
Types of cancer/s are associated with chromosomal translocation (14;18) Follicular lymphoma (bcl-2 activation)
Types of cancer/s are associated with chromosomal translocation (15;17) M3 type of AML (responsive to all-trans retinoic acid)
Types of cancer/s are associated with chromosomal translocation (11;22) Ewing's sarcoma
Types of cancer/s are associated with chromosomal translocation (11;14) Mantle cell lymphoma
Cell type that produces PTH Chief cells of Parthyroid
Cell type that produces calcitonin Parafollicular cells (C cells) of thyroid
Explain the Renin-Angiotnesin-Aldosterone pathway Renin stimulates conversion of Angiotensinogen to angiotensin I which is converted to angiotensin II by ACE. Angio II then stimulates aldosterone production from adrenal cortex (amongst other things)
Part of the cochlea sensitive to High-Frequency sounds Base of cochlea, near oval and round windows
Name the vitamin K clotting factors 2, 7, 9, 10, and protein C and S
Drug that antagonizes with Vitamin K Warfarin
Why is heparin given concurrently as Warfarin is initiated Heparin has a faster onset of action, while Warfarin takes time to have an effect, so while warfarin takes effect, one gives Heparin
Created by: snezya24



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