Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why

Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.

By signing up, I agree to StudyStack's Terms of Service and Privacy Policy.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.

Remove ads
Don't know
Know
remaining cards
Save
0:01
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards




share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Drugs

Drug nameClassActionSide effects
tacrine AchE inhibitor treats alzheimers too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give atropine
echothiophate AchE inhibitor. organophosphate - irreversible treats glaucoma too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give pralidoxime (2-PAM) to cure & atropine to help
isoflurophate AchE inhibitor. organophosphate - irreversible treats glaucoma too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give pralidoxime (2-PAM) to cure & atropine to help
malathion AchE inhibitor. organophosphate - irreversible insecticide too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give pralidoxime (2-PAM) to cure & atropine to help
parathion AchE inhibitor. organophosphate - irreversible insecticide too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give pralidoxime (2-PAM) to cure & atropine to help
sarin AchE inhibitor. organophosphate - irreversible nerve gas in war too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give pralidoxime (2-PAM) to cure & atropine to help
physostigmine AchE inhibitor. carbamate - reversible treats glaucoma and bowel atony. Antidote for OD on atropine, phenothiazine, & TCAs. cataracts & too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give pralidoxime (2-PAM) to cure & atropine to help
neostigmine AchE inhibitor. carbamate - reversible treats ileus, pee retention, & myasthenia gravis. Reverses nondepolarizing Nm blockers (ex: tubocurarine) too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give pralidoxime (2-PAM) to cure & atropine to help
pyridostigmine AchE inhibitor. carbamate - reversible treats ileus, pee retention, & myasthenia gravis. Reverses nondepolarizing Nm blockers (ex: tubocurarine) too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give pralidoxime (2-PAM) to cure & atropine to help
acetylcholine Muscarinic agonist M & N receptors. No clinical use since broken down in blood. leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give atropine
carbachol Muscarinic agonist treats glaucoma. Used to cause miosis during eye surgery. leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give atropine
bethanechol Muscarinic agonist treats ileus & pee retention leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give atropine
methacholine Muscarinic agonist asthma challenge test. Will cause bronchoconstriction leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give atropine
pilocarpine Muscarinic agonist treats glaucoma topically or xerostomia (dry mouth) can cross BBB -> hallucinate & seizure. leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give atropine
atropine Muscarinic blocker - reversible nonselective belladona plant. treats brady, GI spasms/diarrhea, excessive secretion, cystitis, and toxic levels of Ach/mushroom poisoning dry as a bone, blind as a bat (mydriasis+cycloplegia), red as a beet (tachy+hypertherm+vasodil), mad as a hatter, sedation, pee+poo retention. Will cause acute crisis in narrow angle glaucoma. If OD give physostigmine
scopolamine Muscarinic blocker - nonselective belladona plant. Treats motion sickness. dry as a bone, blind as a bat (mydriasis+cycloplegia), red as a beet (tachy+hypertherm+vasodil), mad as a hatter, sedation, pee+poo retention. Will cause acute crisis in narrow angle glaucoma. If OD give physostigmine
tropicamide Muscarinic blocker topical used in ophthalmology to dilate eye dry as a bone, blind as a bat (mydriasis+cycloplegia), red as a beet (tachy+hypertherm+vasodil), mad as a hatter, sedation, pee+poo retention. Will cause acute crisis in narrow angle glaucoma.
ipratropium Muscarinic blocker inhale to treat asthma/COPD dry as a bone, blind as a bat (mydriasis+cycloplegia), red as a beet (tachy+hypertherm+vasodil), mad as a hatter, sedation, pee+poo retention. Will cause acute crisis in narrow angle glaucoma. If OD give physostigmine
benztropine Muscarinic blocker treats parkinsons and symptoms from antipsychotics dry as a bone, blind as a bat (mydriasis+cycloplegia), red as a beet (tachy+hypertherm+vasodil), mad as a hatter, sedation, pee+poo retention. Will cause acute crisis in narrow angle glaucoma. If OD give physostigmine
trihexyphenidyl Muscarinic blocker treats parkinsons and symptoms of antipsychotics dry as a bone, blind as a bat (mydriasis+cycloplegia), red as a beet (tachy+hypertherm+vasodil), mad as a hatter, sedation, pee+poo retention. Will cause acute crisis in narrow angle glaucoma. If OD give physostigmine
meperidine Muscarinic blocker dry as a bone, blind as a bat (mydriasis+cycloplegia), red as a beet (tachy+hypertherm+vasodil), mad as a hatter, sedation, pee+poo retention. Will cause acute crisis in narrow angle glaucoma. If OD give physostigmine
amantadine Muscarinic blocker dry as a bone, blind as a bat (mydriasis+cycloplegia), red as a beet (tachy+hypertherm+vasodil), mad as a hatter, sedation, pee+poo retention. Will cause acute crisis in narrow angle glaucoma. If OD give physostigmine
quinidine Muscarinic blocker dry as a bone, blind as a bat (mydriasis+cycloplegia), red as a beet (tachy+hypertherm+vasodil), mad as a hatter, sedation, pee+poo retention. Will cause acute crisis in narrow angle glaucoma. If OD give physostigmine
succinylcholine Neuromuscular blocker/skel M relaxer (nicotinic Nm receptor) opens Na channels depolarizing the membrane - fasciculations then flaccid paralysis. Used with anesthesia IV. bronchoconstriction, dec bp, resp paralysis, all reversible w/ AchE inhibitors. Beware mutations in Ryr or pseudocholinesterase leading to hyperkalemia & malignant hyperthermia. (Treat with dantrolene to block Ca from leaving SR).
tubocurarine Neuromuscular blocker/skel M relaxer (nicotinic Nm receptor) competes w/ Ach but does not depolarize the M. Used with anesthesia IV - 1st eyes & face, last resp Ms. bronchoconstriction, dec bp, reversed by AchE inhibitors. Beware mutations in Ryr or pseudocholinesterase leading to hyperkalemia & malignant hyperthermia. (Treat with dantrolene to block Ca from leaving SR).
pancuronium Neuromuscular blocker/skel M relaxer (nicotinic Nm receptor) competes w/ Ach but does not depolarize the M. Used with anesthesia IV - 1st eyes & face, last resp Ms. Longer than tubocurarine. bronchoconstriction, dec bp, reversed by AchE inhibitors. Beware mutations in Ryr or pseudocholinesterase leading to hyperkalemia & malignant hyperthermia. (Treat with dantrolene to block Ca from leaving SR).
atracurium Neuromuscular blocker/skel M relaxer (nicotinic Nm receptor) competes w/ Ach but does not depolarize the M. Used with anesthesia IV - 1st eyes & face, last resp Ms. converted to laudanosine which can cause seizures. Bronchoconstriction, dec bp
mivacurium Neuromuscular blocker/skel M relaxer (nicotinic Nm receptor) competes w/ Ach but does not depolarize the M. Used with anesthesia IV - 1st eyes & face, last resp Ms. Bronchoconstriction, dec bp
nicotine Nicotinic blocker competes with Ach. 1st stimulates then blocks by persistent depolarization. Treats HTN emergency block dominant ANS = tachy, vasodil, mydriasis+cycloplegia, pee+poo retention, xerostomia, anhydrosis
hexamethonium Nicotinic blocker competes with Ach. Treats HTN emergency block dominant ANS = tachy, vasodil, mydriasis+cycloplegia, pee+poo retention, xerostomia, anhydrosis
mecamylamine Nicotinic blocker competes with Ach. Treats HTN emergency block dominant ANS = tachy, vasodil, mydriasis+cycloplegia, pee+poo retention, xerostomia, anhydrosis
trimethaphan Nicotinic blocker competes with Ach. Treats HTN emergency block dominant ANS = tachy, vasodil, mydriasis+cycloplegia, pee+poo retention, xerostomia, anhydrosis
phenylephriene α 1 agonist vasoconstricts so inc bp & reflex brady. Treats nasal congestion, hypotension, paroxysmal atrial tachy (via vagal reflex), & used in eye exam to cause mydriasis w/out cycloplegia rebound mucosal swelling & HTN headache
methoxamine α 1 agonist vasoconstricts so inc bp & reflex brady. Treats hypotension & paroxysmal atrial tachy (via vagal reflex) HTN headache
clonidine α 2 agonist dec symp. Treats mild/mod HTN (wont affect kidney) & can help w/ w/drawal from benzos & opiates sedation, orthostatic hypotension, sex dysfunc
methyldopa α 2 agonist dec symp. Treats mild/mod HTN (wont affect kidney) & can help w/ w/drawal from benzos & opiates sedation, orthostatic hypotension, sex dysfunc
dobutamine β agonist (β 1 >>> β 2) inc HR. IV Treats CHF (forces heart to pump enough) arrhythmias, angina, headache, HTN
isoproterenol β agonist (β 1 = β 2) IV Treats AV node block, brady, & bronchospasm arrhythmias, angina, headache, flush
albuterol β 2 agonist inhaled - rapidly treats asthma/COPD skel M tremors, hyperglycemia, arrhythmias, headache
salmeterol β 2 agonist inhaled - treats asthma/COPD but takes longer than albuterol skel M tremors, hyperglycemia, arrhythmias, headache
terbutaline β 2 agonist IV/oral - treats asthma/COPD but takes longer than albuterol. Also treats preterm labor skel M tremors, hyperglycemia, arrhythmias, headache
ritodrine β 2 agonist treats preterm labor skel M tremors, hyperglycemia, arrhythmias, headache
epinephrine agonist for: α 1 = α 2, β 1 = β 2, but β 2 > α 1 so low dose epi is β 2 only but high dose epi is β 2 & α 1 Treats anaphylaxis by vasoconstricting & bronchodilating (could also help asthma attack). Helps local anesthetics/counters hemorrhage. Can't do orally due to rapid breakdown by COMT. Doesn't cross BBB arrhythmias, HTN, headache, skel M tremor, pulmonary edema
norepinephrine agonist for: α 1 = α 2, β 1 >>>>> β 2 vasoconstriction, reflex brady, & inc heart contraction. Helps local anesthetics/counters hemorrhage. Last resort in shock. Can't do orally due to rapid breakdown by COMT. Doesn't cross BBB arrhythmias, dec perfusion of kidneys & tissues
dopamine D1 & D2 agonist at low dose (in renal bv), β1 & β2 at mid dose, α 1 at high dose Treats acute renal failure by inc blood flow, treats shock & CHF by inc HR. Can't do orally due to rapid breakdown by COMT. Doesn't cross BBB arrhythmias, tachy, HTN & dec renal perfusion at high dose
tyramine indirect adrenergic receptor agonist in red wine, beer, cheese, & chocolate. Incs norepi. Broken down by MAO. If on MAO inhibitor beware HTN emergency
methylphenidate amphetamine - indirect adrenergic receptor agonist can cross BBB, releases stores of norepi & dopamine, & inc 5HT. Treats ADHD, narcolepsy, also vasoconstricts so inc bp. psych and physical dependance, psychosis, confusion, insomnia, restless, tachy, arrhythmias, headache. Don't use w/ MAO inhibitor -> HTN emergency. If OD use chlorpromazine to block α helping HTN & CNS.
methamphetamine amphetamine - indirect adrenergic receptor agonist can cross BBB, releases stores of norepi & dopamine, & inc 5HT. Treats ADHD, narcolepsy, also vasoconstricts so inc bp. psych and physical dependance, psychosis, confusion, insomnia, restless, tachy, arrhythmias, headache. Don't use w/ MAO inhibitor -> HTN emergency. If OD use chlorpromazine to block α helping HTN & CNS.
dextroamphetamine amphetamine - indirect adrenergic receptor agonist can cross BBB, releases stores of norepi & dopamine, & inc 5HT. Treats ADHD, narcolepsy, also vasoconstricts so inc bp. psych and physical dependance, psychosis, confusion, insomnia, restless, tachy, arrhythmias, headache. Don't use w/ MAO inhibitor -> HTN emergency. If OD use chlorpromazine to block α helping HTN & CNS.
ephedrine indirect adrenergic receptor agonist releases stores of norepi, also direct agonist for α and β, vasoconstricts, treats nasal congestion, bronchospasm, hypotension tachy, HTN, arrhythmias, insomnia, anxiety (β1 in CNS)
cocaine indirect adrenergic receptor agonist
tricyclic antidepressants indirect adrenergic receptor agonist
prazosin α 1 blocker dec bp by dec peripheral resistance. Treats HTN & BPH reflex tachy, Na/H2O retention, dizzy, orthostatic hypotension, weak, headache, ejaculation probs, GI hypermotility
doxazosin α 1 blocker dec bp by dec peripheral resistance. Treats HTN & BPH reflex tachy, Na/H2O retention, dizzy, orthostatic hypotension, weak, headache, ejaculation probs, GI hypermotility
terazosin α 1 blocker dec bp by dec peripheral resistance. Treats HTN & BPH reflex tachy, Na/H2O retention, dizzy, orthostatic hypotension, weak, headache, ejaculation probs, GI hypermotility
tamsulosin α 1 blocker BPH only (specific for its subset of α 1 receptors) orthostatic hypotension, ejaculation probs
mirtazapine α 2 blocker (also inc 5HT & norepi release) treats depression & anorexia sedation, weight gain, inc blood cholesterol levels
yohimbine α 2 blocker treats orthostatic hypotension & erectile dysfunc
phentolamine nonselective α blocker treats HTN due to pheochromocytoma short-term reflex tachy, orthostatic hypotension, GI hypermotility
phenoxybenzamine nonselective α blocker (IRREVERSIBLE) treats HTN due to pheochromocytoma or spinal cord injury, BPH, & Raynaud's reflex tachy, orthostatic hypotension, ejaculation probs
acebutolol β 1 blocker Treats HTN, MI, CHF, arrhythmias, ischemia, migraine, esophageal variceal bleeding (because dec HR, CO, stroke vol, renin release), open angle glaucoma (dec tear production), essential tremor, & helps w/ thyroid storms & pheochromocytoma (w/ an α blocker) AV node block, brady, HF, hypotension, exercise intolerance, vasoconstrict, rebound HTN/tachy/angina (due to up regulation), bronchoconstrict, hypoglycemia in diabetics, insomnia, nightmares, depression
atenolol β 1 blocker Treats HTN, MI, CHF, arrhythmias, ischemia, migraine, esophageal variceal bleeding (because dec HR, CO, stroke vol, renin release), open angle glaucoma (dec tear production), essential tremor, & helps w/ thyroid storms & pheochromocytoma (w/ an α blocker) AV node block, brady, HF, hypotension, exercise intolerance, vasoconstrict, rebound HTN/tachy/angina (due to up regulation), bronchoconstrict, hypoglycemia in diabetics, insomnia, nightmares, depression
metoprolol β 1 blocker Treats HTN, MI, CHF, arrhythmias, ischemia, migraine, esophageal variceal bleeding (because dec HR, CO, stroke vol, renin release), open angle glaucoma (dec tear production), essential tremor, & helps w/ thyroid storms & pheochromocytoma (w/ an α blocker) AV node block, brady, HF, hypotension, exercise intolerance, vasoconstrict, rebound HTN/tachy/angina (due to up regulation), bronchoconstrict, hypoglycemia in diabetics, insomnia, nightmares, depression
esmolol β 1 blocker - IV short acting Treats HTN, MI, CHF, arrhythmias, ischemia, migraine, esophageal variceal bleeding (because dec HR, CO, stroke vol, renin release), open angle glaucoma (dec tear production), essential tremor, & helps w/ thyroid storms & pheochromocytoma (w/ an α blocker) AV node block, brady, HF, hypotension, exercise intolerance, vasoconstrict, rebound HTN/tachy/angina (due to up regulation), bronchoconstrict, hypoglycemia in diabetics, insomnia, nightmares, depression
propranolol nonselective β blocker treats migraine, HTN, arrhythmia, tachy, performance anxiety, essential tremor, & thyroid storm because it causes bronchoconstrict, vasoconstrict, dec bp, CO, HR, blocks glycogenolysis/gluconeogenesis, & inc LDL/TG (dec HDL) think it out
timolol nonselective β blocker treats glaucoma by dec aqueous humor, migraine, HTN, arrhythmia, tachy, performance anxiety, essential tremor, & thyroid storm because it causes bronchoconstrict, vasoconstrict, dec bp, CO, HR, blocks glycogenolysis/gluconeogenesis, & inc LDL/TG (dec HDL) think it out
pindolol nonselective β blocker
nadolol nonselective β blocker
note for all β blockers names: β 1 selective = levobet B.E.A.M. treats angina, HTN, post-MI, & arrhythmias if OD use glucagon to inc HR via receptors G-protein linked to adenylyl cyclase. Beware rebound if stop drug due to up-regulation & beware lack of warning signs in hypoglycemia
sotalol K channel + β blocker treats arrhythmias look up later
labetolol α 1 + β blocker treats CHF, HTN, A. fib orthostatic hypotension, dizzy, don't use in acute CHF or when not hemodynamically stable
carvedilol α 1 + β blocker treats CHF, HTN orthostatic hypotension, dizzy, don't use in acute CHF or when not hemodynamically stable
haloperidol #1 typical antipsychotic/neuroleptic Most potent - blocks dopamine receptors so deal w/ + symptoms in schizophrenia & psychosis. Also treats Tourette's & Huntington's. If OD use benztropine/trihexyphenidyl or diphenhydramine or dantrolene depending on symptoms inc risk extrapyramidal SE (akinesia, tremors, akathisia, TARDIVE DYSKINESIA) but less anticholinergic SE (dry as a bone, blind as a bat, red as a beet, mad as a hatter). Also causes inc prolactin (so sex dysfunc), inc weight, sedation, dizzy & temp probs
thiothixene typical antipsychotic/neuroleptic More potent - blocks dopamine receptors so deal w/ + symptoms in schizophrenia & psychosis. If OD use benztropine/trihexyphenidyl or diphenhydramine or dantrolene depending on symptoms inc risk extrapyramidal SE (akinesia, tremors, akathisia, TARDIVE DYSKINESIA) but less anticholinergic SE (dry as a bone, blind as a bat, red as a beet, mad as a hatter). Also causes inc prolactin (so sex dysfunc), inc weight, sedation, dizzy & temp probs
fluphenazine typical antipsychotic/neuroleptic More potent - blocks dopamine receptors so deal w/ + symptoms in schizophrenia & psychosis & mania. Injection so dec freq of dosing or noncompliant. If OD use benztropine/trihexyphenidyl or diphenhydramine or dantrolene depending on symptoms inc risk extrapyramidal SE (akinesia, tremors, akathisia, TARDIVE DYSKINESIA) but less anticholinergic SE (dry as a bone, blind as a bat, red as a beet, mad as a hatter). Also causes inc prolactin (so sex dysfunc), inc weight, sedation, dizzy & temp probs
thioridazine typical antipsychotic/neuroleptic Less potent - blocks dopamine receptors so deal w/ + symptoms in schizophrenia & psychosis. If OD use benztropine/trihexyphenidyl or diphenhydramine or dantrolene depending on symptoms inc risk anticholinergic SE (dry as a bone, blind as a bat, red as a beet, mad as a hatter) but less extrapyramidal SE (akinesia, tremors, akathisia, TARDIVE DYSKINESIA). Also causes inc prolactin (so sex dysfunc), inc weight, sedation, dizzy & temp probs
chlorpromazine typical antipsychotic/neuroleptic Less potent - blocks dopamine receptors so deal w/ + symptoms in schizophrenia & psychosis. If OD use benztropine/trihexyphenidyl or diphenhydramine or dantrolene depending on symptoms inc risk anticholinergic SE (dry as a bone, blind as a bat, red as a beet, mad as a hatter) but less extrapyramidal SE (akinesia, tremors, akathisia, TARDIVE DYSKINESIA). Also causes inc prolactin (so sex dysfunc), inc weight, sedation, dizzy & temp probs
loxapine typical antipsychotic/neuroleptic Last resort - blocks dopamine receptors so deal w/ + symptoms in schizophrenia & psychosis. If OD use benztropine/trihexyphenidyl or diphenhydramine or dantrolene depending on symptoms inc risk extrapyramidal SE (akinesia, tremors, akathisia, TARDIVE DYSKINESIA) but less anticholinergic SE (dry as a bone, blind as a bat, red as a beet, mad as a hatter). Also causes inc prolactin (so sex dysfunc), inc weight, sedation, dizzy & temp probs
olanzapine #1 atypical antipsychotic/neuroleptic blocks dopamine & serotonin receptors so deal w/ + & - symptoms in schizophrenia & psychosis. may develop diabetes but less SE than typicals (extrapyramidal, anticholinergic, sex dysfunc, inc weight, sedation, dizzy & temp probs)
clozapine atypical antipsychotic/neuroleptic blocks dopamine & serotonin receptors so deal w/ + & - symptoms in schizophrenia & psychosis. seizures and agranulocytosis (so do weekly blood tests or could die) - so reserved for folks the other drugs don't help. less SE than typicals (extrapyramidal, anticholinergic, sex dysfunc, inc weight, sedation, dizzy & temp probs)
risperidone atypical antipsychotic/neuroleptic blocks dopamine & serotonin receptors so deal w/ + & - symptoms in schizophrenia & psychosis. maybe stroke in elderly but less SE than typicals (extrapyramidal, anticholinergic, sex dysfunc, inc weight, sedation, dizzy & temp probs). If OD use benztropine/trihexyphenidyl or diphenhydramine or dantrolene depending on symptoms
aripiprazole atypical antipsychotic/neuroleptic blocks dopamine & serotonin receptors (partial agonist for some 5HT) so deal w/ + & - symptoms in schizophrenia & psychosis & mania & depression. less SE than typicals (extrapyramidal, anticholinergic, sex dysfunc, inc weight, sedation, dizzy & temp probs). If OD use benztropine/trihexyphenidyl or diphenhydramine or dantrolene depending on symptoms
quetiapine atypical antipsychotic/neuroleptic blocks dopamine & serotonin receptors so deal w/ + & - symptoms in schizophrenia & psychosis & mania. less SE than typicals (extrapyramidal, anticholinergic, sex dysfunc, inc weight, sedation, dizzy & temp probs). If OD use benztropine/trihexyphenidyl or diphenhydramine or dantrolene depending on symptoms
ziprasidone atypical antipsychotic/neuroleptic blocks dopamine & serotonin receptors so deal w/ + & - symptoms in schizophrenia & psychosis & mania. IM for acute cases. could die if elderly but less SE than typicals (extrapyramidal, anticholinergic, sex dysfunc, inc weight, sedation, dizzy & temp probs). If OD use benztropine/trihexyphenidyl or diphenhydramine or dantrolene depending on symptoms
phenelzine MAO inhibitor inc norepi, epi, & serotonin. Treats resistant/atypical depression & anxiety, hypochondriasis beware tyramine in food, TCAs, levodopa, α and β agonists causing too much stimulation. HTN crisis: HTN, arrhythmia, hypertherm. TCAs, SSRIs, meperidine can cause serotonin syndrome. If OD use phentolamine to block αs or chlorpromazine (antipsychotic)
tranylcypromine MAO inhibitor inc norepi, epi, & serotonin. Treats resistant/atypical depression & anxiety, hypochondriasis beware tyramine in food, TCAs, levodopa, α and β agonists causing too much stimulation. HTN crisis: HTN, arrhythmia, hypertherm. TCAs, SSRIs, meperidine can cause serotonin syndrome. If OD use phentolamine to block αs or chlorpromazine (antipsychotic)
serotonin syndrome -- neuroleptic malignant syndrome because of MAO inhibitors, SSRIs, tyramine -- because of haloperidol, fluphenazine, thiothixene or other anitpsychotics overstimulation myoclonus/rigid, hypertherm, tremor/seizures, ANS instability/CV collapse. If emergency give cyproheptadine & will clear sys of the drug
amitriptyline TCA blocks serotonin & norepi reuptake. Treats depression, PTSD, phobia/anxiety & neuropathic pain M & α blocked. fat soluble. Avoid MAO inhibitors. OD = coma, convulsions, arrhythmias.
imipramine TCA blocks serotonin & norepi reuptake. Treats depression, PTSD, phobia/anxiety, panic attacks, & enuresis (bed wetting) M & α blocked. fat soluble. Avoid MAO inhibitors. OD = coma, convulsions, arrhythmias.
clomipramine TCA blocks serotonin & norepi reuptake. Treats depression, PTSD, phobia/anxiety & OCD M & α blocked. fat soluble. Avoid MAO inhibitors. OD = coma, convulsions, arrhythmias.
doxepin TCA blocks serotonin & norepi reuptake. Treats depression, PTSD, phobia/anxiety M & α blocked. fat soluble. Avoid MAO inhibitors. OD = coma, convulsions, arrhythmias.
nortriptyline TCA blocks serotonin & norepi reuptake. Treats depression, PTSD, phobia/anxiety M & α blocked. fat soluble. Avoid MAO inhibitors. OD = coma, convulsions, arrhythmias.
amoxapine TCA blocks serotonin & norepi reuptake. Treats depression, PTSD, phobia/anxiety M & α blocked. fat soluble. Avoid MAO inhibitors. OD = coma, convulsions, arrhythmias.
desipramine TCA blocks serotonin & norepi reuptake. Treats depression, PTSD, phobia/anxiety M & α blocked. fat soluble. Avoid MAO inhibitors. OD = coma, convulsions, arrhythmias.
fluoxetine SSRI blocks serotonin reuptake. #1 for depression, PTSD, & OCD. Also used for bulimia, anxiety, & PMS. anorgasmia, ANXIETY, weight loss, bruxism, inhibits P450. OD = serotonin syndrome.
paroxetine SSRI blocks serotonin reuptake. #1 for depression, PTSD, & OCD. Also used for bulimia, anxiety, & PMS. anorgasmia, anxiety, weight loss, bruxism, SEDATION, inhibits P450. OD = serotonin syndrome.
sertraline SSRI blocks serotonin reuptake. #1 for depression, PTSD, & OCD. Also used for bulimia, anxiety, & PMS. anorgasmia, anxiety, weight loss, bruxism, inhibits P450. OD = serotonin syndrome.
fluvoxamine SSRI blocks serotonin reuptake. #1 for depression, PTSD, & OCD. Also used for bulimia, anxiety, & PMS. anorgasmia, anxiety, weight loss, bruxism, inhibits P450. OD = serotonin syndrome.
citalopram SSRI blocks serotonin reuptake. #1 for depression, PTSD, & OCD. Also used for bulimia, anxiety, & PMS. anorgasmia, anxiety, weight loss, bruxism, inhibits P450. OD = serotonin syndrome.
escitalopram SSRI blocks serotonin reuptake. #1 for depression, PTSD, & OCD. Also used for bulimia, anxiety, & PMS. anorgasmia, anxiety, weight loss, bruxism, inhibits P450. OD = serotonin syndrome.
buproprion dopamine & norepi reuptake inhibitor used for depression & smoking cessation seizure
trazodone blocks serotonin reuptake used for depression & insomnia arrhythmias & priapism (painful long erection)
venlafaxine SNRI blocks serotonin & norepi reuptake. Treats depression & anxiety inc bp
duloxetine SNRI blocks serotonin & norepi reuptake. Treats depression & diabetic peripheral neuropathy inc bp
atomoxetine selective norepi reuptake inhibitor treats ADHD M & α blocked. fat soluble. Avoid MAO inhibitors. OD = coma, convulsions, arrhythmias.
lithium dec inositol phosphate (PIP2/IP3) treats bipolar disorder. Also migraines & chronic aggression very low TI & teratogen (malform of tricuspid valve). Edema (so beware in HF), acne, hypothyroid, tremor, "flu", deadly seizures, coma, hard on kidneys (thiazides & loops will inc tox) nephrogenic diabetes insipidus (dec ADH receptors. fix w/ amiloride)
valproic acid anticonvulsant treats mania, rapid cycling bipolar, & impulse ctrl issues by inc GABA regular blood work to monitor liver tox & agranulocytosis. Teratogen (neural tube defects), coma, & cardiac arrest
carbamazepine anticonvulsant treats mania, rapid cycling bipolar, & impulse ctrl issues by inc GABA regular blood work to monitor liver tox & agranulocytosis. Rash is first warning sign of tox. Teratogen (cleft lip/palate), coma, & cardiac arrest.
gabapentin anticonvulsant GABA analog. treats mania/bipolar if preg later
phenytoin anticonvulsant l
ethosuximide anticonvulsant l
lamotrigine anticonvulsant l
felbamate anticonvulsant l
topiramate anticonvulsant l
vigabatrin anticonvulsant l
phenobarbital sedative/hypnotic - barbiturate & anticonvulsant inc Cl influx DURATION through GABA to hyperpolarize cell. Treats preg woman w/ seizures induce P450 so inc metabolism of fat soluble drugs ex:OCP. Porphyrias, sedation, anesthesia, resp depression, coma, die. Long term=tolerance, psych+phys dependance. Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
thiopental sedative/hypnotic - barbiturate inc Cl influx DURATION through GABA to hyperpolarize cell. Used to induce anesthesia induce P450 so inc metabolism of fat soluble drugs ex:OCP. Porphyrias, sedation, anesthesia, resp depression, coma, die. Long term=tolerance, psych+phys dependance. Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
clonazepam sedative/hypnotic - benzodiazepine inc Cl influx FREQUENCY through GABA to hyperpolarize cell. Treats mania/bipolar if preg & panic attacks/anxiety. Metabolized by liver to an active compound. sedation & anesthesia then plateaus. Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
diazepam sedative/hypnotic - benzodiazepine & anticonvulsant Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
lorazepam sedative/hypnotic - benzodiazepine & anticonvulsant Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
alprazolam sedative/hypnotic - benzodiazepine Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
midazolam sedative/hypnotic - benzodiazepine Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
oxazepam sedative/hypnotic - benzodiazepine Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
temazepam sedative/hypnotic - benzodiazepine Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
flurazepam sedative/hypnotic - benzodiazepine Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
triazolam sedative/hypnotic - benzodiazepine Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs.
zaleplon sedative/hypnotic bzd agonist. Treats sleep disorders. Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs. But less abuse & tolerance.
zolpidem sedative/hypnotic bzd agonist. Treats sleep disorders. Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs. But less abuse & tolerance.
buspirone sedative/hypnotic no effect on GABA. serotonin partial agonist. Used for general anxiety (not sedating) no w/drawl or cross reactivity or abuse potential
ethanol sedative/hypnotic - Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs. aka alcohol. activates GABA complex. sedation, anesthesia, resp depression, coma & dec HR (>300mg/dL), (400mg/dL)death. inc risk GI cancer/bleed, boobs/small balls (liver not breaking estrogen), HTN, fetal al synd. Treats OD of methanol or ethylene glycol alcohol dehydrogenase (zero order. needs NAD) ->acetaldehyde (NV headache) ->acetaldehyde dehydrogenase ->acetic acid (metabolic acidosis). Thiamine def=WernickeKorsakoff: ataxia, confused, ophthalmoplegia (EOM no move). Hepatitis, cirrhosis, pancreatitis
ethylene glycol sedative/hypnotic - Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs. auto antifreeze. activates GABA complex. sedation, anesthesia, resp depression, coma & dec HR, death. alcohol dehydrogenase (zero order. needs NAD) ->glycoaldehyde ->acetaldehyde dehydrogenase ->oxalic acid crystals damage kidneys & metabolic acidosis
methanol sedative/hypnotic - Cross tolerant w/ alcohols, bzds, barbs & other sedative/hypnotic drugs. antifreeze/fuel. activates GABA complex. sedation, anesthesia, resp depression, coma & dec HR, death. alcohol dehydrogenase (zero order. needs NAD) ->formaldehyde ->acetaldehyde dehydrogenase ->formic acid (metabolic acidosis) & blindness
cyproheptadine cure treats OD on antidepressant that caused serotonin syndrome wipes sys clean of the antidepressant you took the time to build up to have an effect. Start from scratch
dantrolene cure treats malignant hyperthermia caused by Neuromuscular blocker/skel M relaxer (nicotinic Nm receptor)
flumazenil BZD blocker treats OD of benzodiazepines
fomepizole inhibits alcohol dehydrogenase so acetaldehyde/formaldehyde don't form so don't get tox. Use in methanol & ethylene glycol poisoning
disulfram inhibits acetaldehyde dehydrogenase so acetaldehyde builds up when ingest ethanol so you get sick. Helps in quitting alcohol. other drugs that act like this: metronidazole, cephalosporins, procarbazine (anticancer)
chlordiazepoxide sedative/hypnotic - benzodiazepine used for alcohol detox
edrophonium AchE inhibitor. reversible treats myasthenia gravis. Use to differentiate btw MG & cholinergic crisis (wont get better). too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give atropine
donepezil AchE inhibitor treats alzheimers too much Ach = leaking from everywhere, miosis, brady, dec bp, skel M excitation then paralysis, broncho constriction. If OD give atropine
Created by: eweeks