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B cell_sloma
Question | Answer |
---|---|
BCR on a mature B cell | surface bound immunoglobulin(Ig) |
generation of B cells | PhaseI of Bcell development in bone marrow Bcells acquire functional receptors thru ordered arrangements |
elimination of self reactive clones | PhaseII of Bcell development in bone marrow Bcells with receptors for self are eliminated |
Activation by antigen | PhaseIII of Bcell development in secondary lymph (lymph nodes) Mature unstimulated B cells migrate to lymph nodes and enter the recirculating pool of lymphocyes |
Differentiation | PhaseIV of Bcell development Secondary lymph(lymph nodes) contact with antigen stimulated B cell proliferation and differentiation into plasma cells and memory b cells |
surface marker for proB-cell | CD19 |
how many attemps for heavy chain recombination of B cell | 2 (because it has 2 copies of HC genes) |
wat makes up the pre b cells receptor | HC, surrogate LC, Ig alpha, Ig beta |
how many attemps does the b cell have to rearrange the LC | 4 (2 kappa chains and 2 lambda chains) |
wat makes up the mature b cell receptor | HC, LC, Ig alpha, Ig beta |
what cell presents Ag to B cell for selection of the right Bcell after affinity maturation | FOllicular Dendritic cell |