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VIral Replication
Viral stuff_S3
Question | Answer |
---|---|
where does the pox virus replicate | in the cytoplasm. therefore has to bring its own DdDpol and DdRpol |
gapped dsDNA | hepadnavireidae (Hep B). first gapped is repaired and then transcriped into RNA and then a reverse transcriptase is made which made the gapped DNA again. |
name a virus that replicates in the nucleus but brings its own DdDpol | herpes |
DdDPol vs. DdRpol | DdDpol can read ssDNA but DdRpol cannot |
what happens if the -RNA virus does not carry its own RdRpol | the -RNA that the virus is carrying gets degraded when they penetrate the host. if the virus penetrates the cell carrying its own pol( which is usually complexed with the RNA), then the -ssRNA gets amplified via a +RNA intermediate |
ribosomes recognize only ssRNA | true |
how are rate and specificity of viral assembly controlled | individual subunits must be present in appropriate cellular compartments in sufficient concentration |
packaging | incorporation of the genomic nucleic acid into the protective structures |
advantage of concerted or coordinated assembly instead of sequential | no increase in structural subunit concentration is required since the units are incorporated as nucleic acid syn progresses. |
release of naked viruses | as a general rule, they are released by host cell lysis - possibly by increasing membrane permeability and/or weaken the cytoskeleton |
which naked viruses dont exit by cell lysis | Hep A, papillomavirus |
sequential model of core formation and envelope acquisition | eg: herpes virus |
simultaneous model of core formation and envelope acquisition | eg: retroviruses |
viral maturation in orthomyxoviridae | orthomyxoviridae is flue virus. involved cleaving of the sialic acid so the virus dont clump together. this increases their chance of infecting host cells. |