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DIT 2009 WK 8
Q&A from DIT emailed questions WK 8
Question | Answer |
---|---|
What is the function of the nucleus ambigous? | Visceral sensory information (eg – taste, baroreceptors, gut distention) VII, IX, I |
What is the function of the nucleus of the solitary tract? | Motor innervation of pharynx, larynx, and upper esophagus (eg-swallowing, palate elevation) IX, X, XI |
What is the function of the dorsal motor nucleus? | Sends autonomic (parasympathetic) fibers to heart, lungs, and upper GI |
Site of action of thiazide diuretics? | Early distal convoluted tubule |
Site of action of loop diuretics? | Thick ascending limb of Loop of Henle |
Site of action of carbonic anhydrase inhibitor diuretics? | PCT |
Site of action of an osmotic diuretic? | PCT, CT, and Loop |
Site of action of potassium sparing diuretic? | Collecting tubule |
Site of action of ADH antagonist diuretic? | Collecting duct |
What diagnostic test allows you to distinguish between primary hyperaldosteronism (Conn’s syndrome) and secondary hyperaldosteronism? | Plasma renin: Low in primary, high in secondary |
Which diuretic is often used in the treatment of hyperaldosteronism? | Spironolactone |
Centrally acting alpha-2 agonist is commonly used to treat hypertension | Sympathoplegics – clonidine, alpha-methyldopa |
Examples of encapsulated bacteria | Strep pneumo, Neisseria meningitides, HiB, Klebsiella pneumoniae |
Test used to detect encapsulated bacteria | Quellung + |
Time frame one would expect to see delirium tremens in an alcoholic? | Peak 2-5 days after last drink |
Manifestations of delirium tremens | In order: autonomic system hyperactivity (tachycardia, tremors, anxiety), psychotic symptoms ( hallucinations, delusions), confusion |
Describe how ammonium is shuttled out of muscle tissue to create urea in the liver | In muscle: Pyruvate + Glutamate -> Alanine (NH3) gets transported to the Liver where: Alanine + alpha-KG -> Glutamate (NH3) -> Urea (NH3) |
Main function of vitamin C | Facilitate irion absorption by keeping iron in Fe2+ reduced state, necessary for hydroxylation of proline and lysine in collagen synthesis, necessary for dopamine B-hydroxylase, which converts dopamine to NE |
MOA of zileuton | 5-lipoxygenase pathway inhibitor, blocks conversion of arachidonic acid to leukotrienes |
MOA of zafirlukast | blocks leukotriene receptors |
Which branchial pouch gives rise to middle ear cavity and Eustachian tube? | 1st Pouch |
Which branchial pouch gives rise to superior parathyroids? | 4th Pouch |
Which branchial pouch gives rise to inferior parathyroids? | 3rd Pouch |
Which branchial pouch gives rise to thymus? | 3rd Pouch |
Which branchial pouch gives rise to mastoid air cells? | 1st Pouch |
Which branchial pouch gives rise to epithelial lining of palatine tonsils? | 2nd Pouch |
Substance used to close a patent ductus arteriosus? | Idomethacin |
Substance used to keep a patent ductus arteriosus open? | PGE |
When might one want to keep a PDA open? | Transposition of Great Vessels |
What is internuclear opthalmoplegia? | Lesion in the medial longitudinal fasciculus -> medial rectus palsy on attempted lateral gaze. Nystagmus in abducting eye. Convergence is normal. Syndrome seein in many pts w/ MS |
diuretic is used to lower intracranial pressure | Mannitol |
contraindications for mannitol | Contraindicated in anuria and CHF |
the R’s of Rifampin | Revs up microsomal p450, Red-orange secretions, RNA polymerase inhibitor, Rapid resistance if used alone |
antifungal drug used for "swish and swallow" | Nystatin |
antifungal drug that is nephrotoxic | Amphotericin B |
antifungal drug that deposits in keratin-containing tissues | Griseofulvin |
antifungal drug used for cryptococcal meningitis in AIDS | Fluconazole |
antifungal drug that is teratogenic and carcinogenic | Griseofulvin |
Which complement protein is an opsonin? | C3b |
Which complement protein aids in neutrophil chemotaxis? | C5a |
Which complement proteins form the membrane attack complex? | C5B-C9 |
What might one see under a light microscope that would lead you to suspect lead poisoning as a cause of microcytic, hypochromic anemia? | erythrocyte basophilic stippling |
Which two calcium channel blockers work primarily on the heart? | Verapimil and Diltiazem |
Type of calcium blocker that works on vascular smooth muscle? | Non-cardio specific: Nifedipine |
Most common causes of seizures in children? | genetic, infection (febrile), trauma, congenital, metabolic |
MCC of seizures in adults? | tumors, trauma, stroke, infection |
MCC of seizures in elderly? | stroke, tumor, trauma, metabolic, infection |