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Bacteria - Micro4
Virulence Factors
Question | Answer |
---|---|
N. meningitidis | IgA protease; endotoxin (petechial rash via necrosis); |
L. monocytogenes | LLO (activated in acidic phagosome --> lyses it); endotoxin; internalin (for penetration of GI) |
M. tuberculosis | mycolic acid (for intracell survival) |
M. leprae | mycolic acid (for intracell survival) |
K. pneumoniae | antiphagocytic capsule |
L. pneumophila | Pili (for attach to resp epithelia) |
P. aeruginosa | Exotoxin A (ADP ribosylates EF2); Phospholipase C (cleaves phosphate to feed bacteria); elastase (cleaves BM for dissemination); endotoxin (sepsis); alginate capsule (impedes clearance); pili |
H. influenza | IgA protease; capsule (w/ PRP) |
B. pertussis | FHA (adherence to cilia); pertussis toxin (ADP ribosylates Gi --> uninhibited adenylate cyclase); secreted adenylate cyclase; tracheal cytotoxin (kills ciliated epithelia) |
C. diphtheria | diphtheria toxin (ADP ribosylates EF2) |
M. pneumoniae | P1 adhesin |
C. psittaci | special cell wall (prevents phagosome-lysosome fusion) |
C. pneumoniae | special cell wall (prevents phagosome-lysosome fusion) |
C. trachomatis | special cell wall (prevents phagosome-lysosome fusion) |
B. cereus | ST (emetic) & LT (diarrheal) |
B. anthracis | porins 1A (bind C4bp/fH) & 1B (bind C4bp) |
N. gonorrhea | IgA protease; pilE/pilS (prevents phagocytosis --> recombinant); endotoxin |
T. pallidum | endotoxin (in Jarisch-Herxheimer rxn) |
B. recurrentis | endotoxin (in Jarisch-Herxheimer rxn) |
B. hermsii | endotoxin (in Jarisch-Herxheimer rxn) |
Y. pestis | endotoxin; F1 capsular antigen (anti-phagocytic) |
S. aureus (infections) | protein A (bind Fc of IgG); coagulase; hemolysins (destroy RBCs); hyaluronidase; staphylokinase (lyses clots); lipase |
S. aureus (toxin) | TSST-1 (TSS); exfoliative toxin A & B (scalded skin); enterotoxin SE-A (food poisoining) |
S. epidermidis | polysaccharide capsule |
S. pneumoniae | capsule (anti-C3b) |
S. pyogenes (immune) | M protein (antiphagocytic); streptolysin O |
S. pyogenes (infections) | M protein (antiphagocytic); streptokinase (fibrinolysis); hyaluronidase; DNase; Streptlysin O |
S. pyogenes (toxin) | M protein (antiphagocytic); streptolysin O; Exotoxin A/B/C (scarlet fever), A (TSS), B (nec. fasciitis) |
S. agalactiae (GBS) | capsule |
E. faecalis | capsule (no bile degradation) |
S. bovis | capsule (no bile degradation) |
S. viridans | capsule |
Shigella dysenteriae | Shet 1/2 (invades M cells --> apoptosis --> depurinates 28S rRNA); O antigen |
Salmonella typhi | Vi capsule (allow survival in phagocytes); endotoxin |
Salmonella enteritidis | Vi capsule (allow survival in phagocytes); endotoxin |
ETEC | LT (inc cAMP via ADP ribosylates Gs) & ST (inc cGMP) |
EHEC/STEC | SLT 1/2 --> inactivate 60S via 28s depurination |
EPEC | flattening of villi --> malabsorption |
EIEC | SLT 1/2 --> inactivate 60S via 28s depurination |
E. coli (others) | Endotoxin |
Y. enterocolitica | ST enterotoxin (inc cGMP) |
Proteus mirabilis | Urease (splits urea to NH4OH --> inc pH --> struvite calculi); O antigen |
H. pylori | urease (produces ammonia --> inc pH); arginase; SOD |
V. cholera | mucinase (difests mucous coat around intestinal cells); cholera toxin (irbosylated Gs --> inc cAMP) |
V. parahaemolytica | mucinase (difests mucous coat around intestinal cells); cholera toxin (irbosylated Gs --> inc cAMP) |
C. jejuni | Enterotoxin (cholera-like); cytotoxin |
C. botulinum | Botulinum toxin (LT toxin --> blocks ACh release from nerve terminals) |
C. tetani | Tetanospasmin (retrogradely on axon --> blocks GABA/glycine release from Renshaw interneurons --> hyperexcitement of motor nerves) |
C. difficile | toxin A (alters fluid secretions) & B (cytotoxic to epithelial cells) |
C. perfringens | Degredative enzymes (cellulitis); a-toxin (muscle cell necrosis); enterotoxin (LT, inhibits glucose transport) |
B. fragilis | capsule; only Gram- LACKS endotoxin |