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Bacteria - Micro3
Vector/Mode of Attack
| Question | Answer |
|---|---|
| N. meningitidis | Nasopharynx --> phagocytosis across mucosa |
| L. monocytogenes | poorly pasteurized milk or lunch meat --> invade GI mucosa/phagocytes (facultative intra) |
| M. tuberculosis | aerosol droplets |
| M. bovis | unpasteurized milk |
| M. leprae | nasal discharge (grows @ low temp areas of body) |
| K. pneumoniae | Normal intestinal flora |
| L. pneumophila | water reservoirs, but inhaled via aerosols (resp devices & AC units) |
| P. aeruginosa | via breach of host defense barries (catheters, burns, intubations) --> normally soil/water |
| H. influenza | aerosol droplets --> URT --> may invade submucosa & blood |
| B. pertussis | aerosol droplets --> adhere cilia of tracheobronchial tree |
| C. diphtheria | aerosol droplets (nasopharynx) |
| M. pneumoniae | aerosol droplets --> adhere (via P1 adhesin) cilia of tracheobronchial tree |
| C. psittaci | bird feces --> aerosol --> URT (invades) --> alveoli (EB --> RB --> EB) |
| C. pneumoniae | aerosol --> URT (invades) --> alveoli (EB --> RB --> EB) |
| C. trachomatis | D-K: infects GU columnar epithelia (neonatal as passes through canal); A-C: hand-eye contact; L1-L3: painless ulcer @ site infection |
| B. cereus | contaminated food (reheated rice) |
| B. anthracis | Spores from goats/cows or in soil (contact) |
| N. gonorrhea | attaches via pili to mucosal cells of urethra/vagina |
| T. pallidum | Sexual/casual contact --> penetrates mucous membranes --> systemic spread; transplacental |
| B. burgdorferi | Ixodes tick (from mice) |
| B. recurrentis | human body louse |
| B. hermsii | ticks |
| Leptospire interrogans | rodents/dogs/fish shed in URINE --> contaminated water (swimming) --> enter mucosal abrasion |
| Y. pestis | flea (from rodents) --> phagocytosed to LNs; aerosol --> alveoli |
| Francisella tularensis | ticks (from rabbits) --> multiple locally --> phagocytosed to RES (caseating granuloma) |
| Brucella spp. | unpasteurized milk --> phagocytosed to RES (caseating granuloma/abscess) |
| R. prowazekii | louse (from flying squirrels) --> infects endothelia |
| R. typhi | flea (from rodents) --> infects endothelia |
| R. tsutsugamushi | chiggers (from rodents) --> infects endothelia |
| R. rickettsii | wood/dog tick (from dog/rodents) --> prolif in endothelia |
| R. akari | mites (from mice) --> papule @ site |
| Coxiella burnetii | sheep/cattle (in animal products) --> inhalation of spores |
| Gardnerella vaginalis | normal vaginal flora |
| Ehrlichia chaffeensis (HME) | ticks |
| Anaplasma phagocytophilum (HGE) | Ixodes tick (from mice) |
| Bartonella quintana | body louse |
| Bartonella bacilliformis | sandfly |
| Bartonella henselae | cat scratch/cat flea |
| S. aureus (infections) | defense barrier breach or nasopharynx --> may invade bloodstream |
| S. aureus (toxin) | tampon use or trauma/surgery (TSS); skin wound/umbilicus (scalded skin); food ingestion (food poisoning) |
| S. epidermidis | normal skin flora --> adhere inserted medical device |
| S. saprophyticus | enter urinary tract via sexual activity (women) |
| S. pneumoniae | aerosol droplets (nasopharynx) --> to middle ear, sinuses, lung lymphatics to blood (lack of anti-capsular IgG) |
| S. pyogenes (immune) | skin infection/pharyngitis (glom) or pharyngitis (RF) --> anti-strep Abs deposit in glom BM or cross-react with heart/joints |
| S. pyogenes (infections) | aerosol droplets (adhere pharyngeal epithelia) or skin trauma (leading to infection) |
| S. agalactiae (GBS) | normal gut & transient vaginal flora |
| E. faecalis | normal gut flora --> overgrows when CEPHALOSPORINS remove rest flora |
| S. bovis | normal lower GI flora --> pentrates via colonic lesions (CANCER) --> bloodstream |
| S. viridans | normal oropharynx (S. mutans) --> ferments glucose --> demineralizes enamel; normal GI (S. intermedius) |
| Shigella dysenteriae | fecal-oral --> endocytosed by colon --> spreads cell-cell |
| Salmonella typhi | fecal-oral --> penetrate distal ilea/colon (Peyer's patches) --> spread via phagocytosis (gallbladder) |
| Salmonella enteritidis | turtles/uncooked chicken --> penetrate distal ilea/colon |
| ETEC | pili adhere (noninvade) jejunum/ileum |
| EHEC/STEC | (zoonotic) pili adhere (noninvade) colon --> toxins may enter blood (to kidneys) |
| EPEC | pili adhere (noninvade) ileum |
| EIEC | pili adhere (invade) colon |
| E. coli (others) | pili adhere urethra --> may ascend |
| Y. enterocolitica | raw milk --> terminal ileum --> invades/inflammation --> ulcerates --> may go to mesenteric LNs |
| Proteus mirabilis | normal GI flora or soil --> enter urinary tractt |
| H. pylori | ingested --> colonize antrum (not invade) |
| V. cholera | water/shellfish --> attaches proximal small intestine |
| V. parahaemolytica | raw seafood (Japan) |
| C. jejuni | poultry/cattle via fecal-oral --> colonizes terminal ileum (invades) |
| C. botulinum | Canned foods/honey |
| C. tetani | soil --> enter skin wound |
| C. difficile | normal Gi flora --> antibiotic treatment clears rest flora (survives via spores) --> few competing flora now |
| C. perfringens | soil/meat/poultry |
| B. fragilis | normal GI flora --> perforation --> spills into peritoneum (facultative anaerobes clear out all O2) |
Created by:
lamsonma
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