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Bacteria - Micro3

Vector/Mode of Attack

N. meningitidis Nasopharynx --> phagocytosis across mucosa
L. monocytogenes poorly pasteurized milk or lunch meat --> invade GI mucosa/phagocytes (facultative intra)
M. tuberculosis aerosol droplets
M. bovis unpasteurized milk
M. leprae nasal discharge (grows @ low temp areas of body)
K. pneumoniae Normal intestinal flora
L. pneumophila water reservoirs, but inhaled via aerosols (resp devices & AC units)
P. aeruginosa via breach of host defense barries (catheters, burns, intubations) --> normally soil/water
H. influenza aerosol droplets --> URT --> may invade submucosa & blood
B. pertussis aerosol droplets --> adhere cilia of tracheobronchial tree
C. diphtheria aerosol droplets (nasopharynx)
M. pneumoniae aerosol droplets --> adhere (via P1 adhesin) cilia of tracheobronchial tree
C. psittaci bird feces --> aerosol --> URT (invades) --> alveoli (EB --> RB --> EB)
C. pneumoniae aerosol --> URT (invades) --> alveoli (EB --> RB --> EB)
C. trachomatis D-K: infects GU columnar epithelia (neonatal as passes through canal); A-C: hand-eye contact; L1-L3: painless ulcer @ site infection
B. cereus contaminated food (reheated rice)
B. anthracis Spores from goats/cows or in soil (contact)
N. gonorrhea attaches via pili to mucosal cells of urethra/vagina
T. pallidum Sexual/casual contact --> penetrates mucous membranes --> systemic spread; transplacental
B. burgdorferi Ixodes tick (from mice)
B. recurrentis human body louse
B. hermsii ticks
Leptospire interrogans rodents/dogs/fish shed in URINE --> contaminated water (swimming) --> enter mucosal abrasion
Y. pestis flea (from rodents) --> phagocytosed to LNs; aerosol --> alveoli
Francisella tularensis ticks (from rabbits) --> multiple locally --> phagocytosed to RES (caseating granuloma)
Brucella spp. unpasteurized milk --> phagocytosed to RES (caseating granuloma/abscess)
R. prowazekii louse (from flying squirrels) --> infects endothelia
R. typhi flea (from rodents) --> infects endothelia
R. tsutsugamushi chiggers (from rodents) --> infects endothelia
R. rickettsii wood/dog tick (from dog/rodents) --> prolif in endothelia
R. akari mites (from mice) --> papule @ site
Coxiella burnetii sheep/cattle (in animal products) --> inhalation of spores
Gardnerella vaginalis normal vaginal flora
Ehrlichia chaffeensis (HME) ticks
Anaplasma phagocytophilum (HGE) Ixodes tick (from mice)
Bartonella quintana body louse
Bartonella bacilliformis sandfly
Bartonella henselae cat scratch/cat flea
S. aureus (infections) defense barrier breach or nasopharynx --> may invade bloodstream
S. aureus (toxin) tampon use or trauma/surgery (TSS); skin wound/umbilicus (scalded skin); food ingestion (food poisoning)
S. epidermidis normal skin flora --> adhere inserted medical device
S. saprophyticus enter urinary tract via sexual activity (women)
S. pneumoniae aerosol droplets (nasopharynx) --> to middle ear, sinuses, lung lymphatics to blood (lack of anti-capsular IgG)
S. pyogenes (immune) skin infection/pharyngitis (glom) or pharyngitis (RF) --> anti-strep Abs deposit in glom BM or cross-react with heart/joints
S. pyogenes (infections) aerosol droplets (adhere pharyngeal epithelia) or skin trauma (leading to infection)
S. agalactiae (GBS) normal gut & transient vaginal flora
E. faecalis normal gut flora --> overgrows when CEPHALOSPORINS remove rest flora
S. bovis normal lower GI flora --> pentrates via colonic lesions (CANCER) --> bloodstream
S. viridans normal oropharynx (S. mutans) --> ferments glucose --> demineralizes enamel; normal GI (S. intermedius)
Shigella dysenteriae fecal-oral --> endocytosed by colon --> spreads cell-cell
Salmonella typhi fecal-oral --> penetrate distal ilea/colon (Peyer's patches) --> spread via phagocytosis (gallbladder)
Salmonella enteritidis turtles/uncooked chicken --> penetrate distal ilea/colon
ETEC pili adhere (noninvade) jejunum/ileum
EHEC/STEC (zoonotic) pili adhere (noninvade) colon --> toxins may enter blood (to kidneys)
EPEC pili adhere (noninvade) ileum
EIEC pili adhere (invade) colon
E. coli (others) pili adhere urethra --> may ascend
Y. enterocolitica raw milk --> terminal ileum --> invades/inflammation --> ulcerates --> may go to mesenteric LNs
Proteus mirabilis normal GI flora or soil --> enter urinary tractt
H. pylori ingested --> colonize antrum (not invade)
V. cholera water/shellfish --> attaches proximal small intestine
V. parahaemolytica raw seafood (Japan)
C. jejuni poultry/cattle via fecal-oral --> colonizes terminal ileum (invades)
C. botulinum Canned foods/honey
C. tetani soil --> enter skin wound
C. difficile normal Gi flora --> antibiotic treatment clears rest flora (survives via spores) --> few competing flora now
C. perfringens soil/meat/poultry
B. fragilis normal GI flora --> perforation --> spills into peritoneum (facultative anaerobes clear out all O2)
Created by: lamsonma



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