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Clopidogrel
| Question | Answer |
|---|---|
| Type | Potent inhibitor of platelet aggregation |
| Presentation | Tablet – 75 mg |
| Action | A specific and potent inhibitor of platelet aggregation: It does this by binding specifically and irreversibly to the platelet P2RY12 purinergic receptor, inhibiting ADP mediated platelet activation and aggregation Onset>30 minutes |
| Use | Patients with an acute ST elevation myocardial infarction who meet the requirements for early percutaneous coronary intervention (PCI) procedure. |
| Adverse Effects | 1. Headache 2. Dizziness 3. Stomach disturbances/pain 4. Diarrhoea or constipation |
| Contraindications | 1. Known allergy 2. Known internal bleed within 6 months, 3. Current use of anticoagulants (excluding Aspirin or Clopidogrel), |
| Dose | 8 x 75 mg tablets (600 mg) – taken orally Not to be dissolved but can be taken with water. |