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Amiodarone
Question | Answer |
---|---|
Type: | Potent anti-arrythmic agent |
Presentation: | Ampoule 150 mg/3ml |
Actions: | Prolongs action potential duration, inc refratoriness - Blocks Na+ channels - Ca2+ blockade, antiadrenergic effects - Prolongs QT(global prolongation of repolarisation - Delay in AV node conduction |
Use: | Slow ventricular rate in AF and AFl, to Rx VF & VT |
Adv Eff: | Vasodilation & neg inotropic effects; hypotension...occasionally brady(elderly), phlebitis, flushes/sweating |
Contras: | KSAR, cross sensitivity to iodine |
Dose: | VF: Adult 300mg over 30-60seconds, paed 5mg/kg VT, AF & AFl: 150mg springfuser(10min, 7ml), paed 5mg/kg |
Special note: | potentiaters: Digoxin, Dilantin, B blockers, Ca channel blockers |