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Pathology

Path

QuestionAnswer
Rb1 retinoblastoma, osterosarcoma, breast, colon, lung (BCL)
NF1 NF1, neuroblastoma
NF2 NF2, menangioma, schwannoma (acoustic)
BRCA1/2 breast (both), ovary (female)
APC stomac, pancreas, colon, familial APC
TGF-beta colon
SMAD 2/4 colon, pancreas
E-cadherin stomach, familial gastric cancer
WT1 Wilms' tumor
PTEN prostate, endometrial, cowden's syndrome
p53 most cancers, Li Fraumani syndrome
P16Ink4a malignant melanoma, pancreas, breast, esophageal
LKB1 Peutz-Jegher
VHL Renal cell carcinoma
MEN1 Multiple endocrine neoplasia 1/2
RET Multiple endocrine neoplasia 1/2
PTCH nevoid basal cell carcinoma
Defective DNA repair xeroderma, bloom syndrome, fanconi anemia, ataxia-telangiectasia
familiar cancer breast, ovarian, pancreatic
cushings small-cell, pancreatic, neural tumor (ACTH)
SIADH small-cell (ADH/ANF)
Hypercalcemia squamous cell carcinoma, breast, renal, adult T-cell leukemia/lymphoma (PTH-related protein, TGF-alpha, TNF, IL1)
Hypoglycemia Ovarian, fibrosarcoma (insulin/insulin-like)
Carcinoid hepatocellular, bronchial, pancreatic (serotonin, bradykinin)
Polycythemia gastric, renal, cerebellar hemangioma, hepatocellular (erythrpoeitin)
Myasthenia bronchogenic carcinoma
acanthosis nigrican gastric, lung, uterine (EGF)
dermatomyositis bronchogenic, breast carcinoma
trousseau phenomenon bronchogenic
red cell aplasia thymic neoplasms
clubbing of fingers bronchogenic
CA-125 ovarian
CA-15-3 breast
CA-19-9 pancreatic, colon (P & P = backwards 9-9)
hCG nonseminomatous testicular tumor, trophoblastic tumor
calcitonin medullary carcinoma of thyroid
catecholamines pheochromocytoma
alpha-fetoprotein liver cell cancer, nonseminomatous germ cell tumor of testis
CEA colon, pancreas, lung, stomach, heart
neuron specific enolase small cell carcinoma, neuroblastoma
Igs multiple myeloma
PSA prostate
p53, APC, RAS mutants in stool colon
p53/RAS in stool pancreatic
p53/RAS in sputum lung
p53 in urine bladder
rubella PDA, cataracts, deafness
CMV urine cytology diagnosis, periventricular necrosis & calcification
syphilis pneumonia alba, copius nasal discharge, periostitis
herpes simplex ascending infection, small necrotic lesions
coxsackievirus B myocarditis
parvovirus B19 hyrdrops, RBC inclusions
toxoplasmosis multifocal cereberal calcifications
vinyl chloride liver angiosarcoma
arsenic GI, CV, CNS interference
Cadmium obstructive lung disorder, renal tubular damage
mercury neuromotor, cognitive, behavior disruption
benzene leukemia
dioxin chloracne, skin folliculitis
organochlorines potent endocrine disruption (anti estrogen/androgen)
Created by: lamsonma