Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Don't know
Know
remaining cards
Save
0:01
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Antibiotics

AB

QuestionAnswer
Fosfomycin inhibits binding of PEP to GlcNAc --> no production of MurNAc (analog of PEP)
D-cycloserine inhibits production of pentapeptide by blocking action of D-Ala racemase & ligase (analog of D-Ala)
Vancomycin inhibits transglycosylation (flipping out and joining of adjacant GlcNAc-MurNAc) --> binds to D-Ala-D-Ala = inc in osmotic lysis
Bacitracin inability to recycle GCL-P, therefore, unable to bind to cytoplasmic membrance to begin formation of peptidoglycan
Penicillin/Cephalosporin form stable structure with transpeptidase so cross-linking CAN'T take place
Linezolid Bind to the 23S of the 50S subunit --> instable 70S; cidal = streptococci & static = staph & enterococci
Aminoglycosides Bind to & interfer with proteins of the 30S; bactericidal; broad spectrum; nephro-/ototoxicity
Streptomycin AMINOGLYCOSIDE; 1) produce kink @ A-site = misreading and incorrect codon inserted, 2) production of faulty outer membrane proteins = leaky membrane, 3) inability of polysomal production = 70S instability = fall apart
Spectinomycin forms instable 70S complex (not misreading); bacteriostatic; GONORRHEA treatment (when beta-lactamase producing species)
Tetracyclines bind to 30S & inhibit binding of aa-tRNA @ A-site; bacteriostatic; broad spectrum; RESISTANCE: mutation in OmpF (no uptake)
Chloramphenicol binds to 50S & alters tRNA structure (no ability to add aa-tRNA to A-site); bacteriostatic; broad spectrum; RESISTANCE: acetyltransferases that acetylate the hydroxyl group
Lincomycin/Clindamycin binds to 50S & alters tRNA structure = no ability to add aa-tRNA to A-site); bacteriostatic; narrow spectrum (G+ bacteria, clind = anaerobic G- or bacteroides); RESISTANCE: methylation of 23S rRNA
Macrolides erythromycin derived (w/ lactone ring); block movement along mRNA; bacteriostatic; medium spectrum (Mycoplasma, Legionella, Chlamydia, Camplylogacter); RESISTANCE: methylation of 23s rRNA or hydrolysis of lactone ring by esterase
Ketolides (Telithromycin) binding w/in exit tunnel of 50S rRNA = no ability to fully produce nascent polypeptide; static or cidal
Streptogramins Dalfopristin (bind 50S --> prevent elongation); Quinupristin (premature release of peptide chains); Synercid (both); static (either alone) or cidal (synercid)
Sulfonamides inhibits folic acid synthesis via dihydropteroate synthetase (no dihydropteroic acid); analog of PABA; bacteriostatic; broad spectrum (NOT M. tuberculosis); CAN'T synthesize thymidine/uridine
Trimethoprim inhibits dihydrofolate reductase = NO BH4; analong of BH2; bacteriostatic; broad spectrum
PAS inhibits folic acid synthesis via dihydropteroate synthetase (no dihydropteroic acid); effective on M. tuberculosis
Rifampin/Rifabutin binds to beta-subunit of RNA pol (no unwinding); bacteriocidal; narrow spectrum (strep/staph, neisseria, mycobacteria); NO TRANSCRIPTION
Quinolones bind to DNA gyrase --> unable to unwind DNA; bactericidal; narrow (nalidoxic acid = no Pseudomonas) or broad (rest); treatment of UTIs
Metronidazole disrupts DNA/inhibits replication/DNA breaks; administered as a prodrug & metabolized by oxidoreducatses (H. pylori/E. histolytica/Giardia); Bactericidal; narrow spectrum
Polymyxins (Colistin) hydrophobic tail (insert into membrane) & hydrophilic head (binds to PE/LPS to disrupt membrane); bactericidal; narrow spectrum (pseudomonas)
Amphotericin B (& nystatin) hydrophobic face (bind to ergosterol) & hydrophilic face (forms pore for leakage of H2O/electrolytes); lead to NVD, NEPHROTOXIC, ANEMIA
Azoles inhibit ergosterol synthesis (via 14-alpha-demethylase)
Allylamines inhibit ergosterol synthesis (via squalene epoxidase)
Echinocandins block cell wall synthesis (via 1,3-beta glucan synthase)
Flucocytosine replace uracil w/ 5-flurouracil in fungal RNA; interfere w/ DNA synthesis via inhibition of thymidylate synthetase
Created by: lamsonma