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MDD Meds
Mental Health
| Question | Answer |
|---|---|
| amitriptyline (Elavil) | antidepressant TCA |
| amoxapine (Ascendin) | antidepressant TCA |
| desipramine (Sinequan) | antidepressant TCA |
| imipramine (Tofranil) | antidepressant TCA |
| nortiptyline (Pamelor) | antidepressant TCA |
| TCA antidepressants MOA | blocks reuptake of serotonin and norepinephrine in CNS. Has significant anticholinergic properties. |
| TCA antidepressant Treatment | Depression and adjunctive treatment for pain, anxiety, insomnia |
| TCA notes | Do not drink alcohol (potientally fatal CNS depression and overdose) concurrent use with MAOI and tryamine foods may lead to hypertensive crisis. |
| Anticholingergic Effects | dry mouth, orthostatic hypotension, increased HR,constipation, urinary retention/hesitancy, mydriasis, blurred vision, dry eyes, photosensitivity. |
| TCA therapeutic time | 2-6weeks |
| Citalopram (Celexa) | SSRI antidepressant |
| escitalopram (Lexapro) | SSRI antidepressant |
| fluoxetine (Prozac) | SSRI antidepressant |
| paroxetine (Paxil) | SSRI antidepressant |
| sertraline (Zoloft) | SSRI antidepressant |
| SSRI MOA | inhibit reuptake of serotonin. Potentiating neuronal activity of serotonin has little effect on norepinephrine or dopamine. |
| SSRI treatment | drepression, panic disorder, PTSD, bulimia, OCD, PDD, anxiety. |
| SSRI combined with antipsychotics | EPS are increased. |
| Serotonin Syndrome | potentially fatal result of excess serotonin activity when SSRI are combined with MAOIs, St. John's Wort, or typtophan. |
| Serotonin Syndrom Symptoms | changes in mental status, muscle spasms, hyperreflexia, diaphoresis, shivering, tremors, diarrhea, abdominal cramps, nausea, ataxia, and headache. |
| SSRI theapeutic time | 2-6 weeks |
| bupropion (Wellbutrin) | Novel antidepressant |
| duloxetine (Cymbalta) | Novel antidepressant |
| venlafaxine (Effexor) | Novel antidepresant |
| Novel antidepressant MOA | inhibit reuptake of norepinephrine, dopamine, and serotonin. |
| Novel antidepressant treatment | depression, stop smoking, insomnia, anxiety disorder |
| isocarboxazid (Marplan) | MAOI antidepressant |
| phenelzine (Nardil) | MAOI antidepressant |
| tranylcypromine (Parnate) | MAOI antidepressant |
| moclobemide (Manerix) | MAOI antidepressant |
| MAOI antidepressant MOA | block the enzyme monamineoxidase tht breaks down neurotransmitters. |
| MAOI antidepressant treatment | depression that will not respond to other treatments. |
| Hypertensive Crisis w/ MAOIs | Potentially fatal drug interactions with foods containing tyramine, SSRI, MAOI, TCA, Demerol, CNS depressants, OTC cold and allergy products, weight loss products, Ritalin, bronchodialators, and some antihypertensives. |
| foods containing tryamine | aged cheese,preserved meat, liver, organ meats, fava beans, sauerkraut, banana peel, draft beer, redwine, soy sauce, caffeine |
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