Question 1

What administration considerations apply to warfarin?

Accepted Answer

Administer orally.
Measure baseline vital signs and prothrombin time (PT), reported as an international normalized ratio (INR).
Monitor INR; recommend reduced dosage for an INR above 2 to 3, depending on condition being treated, and an increased dosag

Question 2

What administration considerations apply to heparin/enoxaparin?

Accepted Answer

Measure baseline vital signs, CBC, platelet count, and hematocrit.
Administer subcutaneously or IV, usually every 12 hr.
Use an infusion pump for continuous IV administration; monitor rate of infusion every 30 to 60 min.
Monitor aPTT every 4 to 6 hr

Question 3

What administration considerations apply to clopidogrel?

Accepted Answer

Give daily dose orally, with or without food.
Check platelet counts periodically.
Discontinue 1 week before elective surgery.

Question 4

What administration considerations apply to desmopressin?

Accepted Answer

Administer IV or intranasally.
Dilute IV form in 0.9% sodium chloride solution.
Administer slowly via IV bolus over 15 to 30 min.
Administer desmopressin (Stimate) intranasally; nasal DDAVP does not treat hemophilia.
Spray the nasal form high into the

Question 5

What administration considerations apply to epoetin?

Accepted Answer

Obtain baseline blood pressure, CBC, Hgb, BUN, uric acid, phosphorus, potassium, creatinine, transferrin saturation, and ferritin concentration and monitor periodically; for HIV, obtain an erythropoietin level.
Make sure to control blood pressure for c

Question 6

What administration considerations apply to factor VIII concentrate, factor IX concentrate?

Accepted Answer

Administer solutions of the powdered form IV.
Administer slowly via IV bolus over 5 to 10 min.
Give on demand to manage bleeding episodes.
For prophylaxis (to prevent bleeding), administer on a regular dosing schedule, generally one to three times per

Question 7

What administration considerations apply to Folic Acid?

Accepted Answer

Give orally (preferable), subcutaneously, IM, or IV
Check vitamin B12 levels to confirm absence of B12 deficiency
Obtain baseline serum folate, Hgb, Hct, RBC, and reticulocyte count and monitor periodically thereafter. Hct should start to improve within

Question 8

What administration considerations apply to ferrous sulfate, iron dextran?

Accepted Answer

Ferrous sulfate (Feosol)
Liquid preparations
dilute in another compatible liquid
give through a straw
rinse with water
Spread doses evenly across waking hours to maximize the production of RBCs
Give the drug on an empty stomach for best absorption

Question 9

What administration considerations apply to filgrastim?

Accepted Answer

Obtain a baseline CBC with differential and platelet count and monitor twice weekly thereafter.
Administer filgrastim by intermittent or continuous IV infusion or subcutaneous injection.
Do not shake vials or mix with other drugs.
Use each vial for o

Question 10

What administration considerations apply to vitamin B12, cyanocobalamin?

Accepted Answer

Give orally, subcutaneously, IM, or intranasally
Confirm gastric absorption of B12 via Schilling test (for oral dosing)
Most clients can absorb adequate amounts of vitamin B12 if large oral doses are given
Give oral forms with food to enhance absorptio

Question 11

What administration considerations apply to alteplase?

Accepted Answer

Administer via IV infusion.
Give thrombolytic agents ASAP within onset of symptoms (less than 2 hr for MI, 3–4.5 hr for CVA).
Obtain baseline platelet counts, Hgb, Hct, aPTT, PT, INR, and fibrinogen levels, and monitor periodically.
Obtain baseline vit

Question 12

What administration considerations apply to oprelvekin?

Accepted Answer

Obtain a baseline CBC with differential and platelet count plus measure serum electrolytes and monitor periodically thereafter
Administer subcutaneously once daily 4 to 6 hr after chemotherapy.
Continue therapy until platelet counts are above 50,000/mm3

Question	Answer
What administration considerations apply to warfarin?	Administer orally. Measure baseline vital signs and prothrombin time (PT), reported as an international normalized ratio (INR). Monitor INR; recommend reduced dosage for an INR above 2 to 3, depending on condition being treated, and an increased dosag
What administration considerations apply to heparin/enoxaparin?	Measure baseline vital signs, CBC, platelet count, and hematocrit. Administer subcutaneously or IV, usually every 12 hr. Use an infusion pump for continuous IV administration; monitor rate of infusion every 30 to 60 min. Monitor aPTT every 4 to 6 hr
What administration considerations apply to clopidogrel?	Give daily dose orally, with or without food. Check platelet counts periodically. Discontinue 1 week before elective surgery.
What administration considerations apply to desmopressin?	Administer IV or intranasally. Dilute IV form in 0.9% sodium chloride solution. Administer slowly via IV bolus over 15 to 30 min. Administer desmopressin (Stimate) intranasally; nasal DDAVP does not treat hemophilia. Spray the nasal form high into the
What administration considerations apply to epoetin?	Obtain baseline blood pressure, CBC, Hgb, BUN, uric acid, phosphorus, potassium, creatinine, transferrin saturation, and ferritin concentration and monitor periodically; for HIV, obtain an erythropoietin level. Make sure to control blood pressure for c
What administration considerations apply to factor VIII concentrate, factor IX concentrate?	Administer solutions of the powdered form IV. Administer slowly via IV bolus over 5 to 10 min. Give on demand to manage bleeding episodes. For prophylaxis (to prevent bleeding), administer on a regular dosing schedule, generally one to three times per
What administration considerations apply to Folic Acid?	Give orally (preferable), subcutaneously, IM, or IV Check vitamin B12 levels to confirm absence of B12 deficiency Obtain baseline serum folate, Hgb, Hct, RBC, and reticulocyte count and monitor periodically thereafter. Hct should start to improve within
What administration considerations apply to ferrous sulfate, iron dextran?	Ferrous sulfate (Feosol) Liquid preparations dilute in another compatible liquid give through a straw rinse with water Spread doses evenly across waking hours to maximize the production of RBCs Give the drug on an empty stomach for best absorption
What administration considerations apply to filgrastim?	Obtain a baseline CBC with differential and platelet count and monitor twice weekly thereafter. Administer filgrastim by intermittent or continuous IV infusion or subcutaneous injection. Do not shake vials or mix with other drugs. Use each vial for o
What administration considerations apply to vitamin B12, cyanocobalamin?	Give orally, subcutaneously, IM, or intranasally Confirm gastric absorption of B12 via Schilling test (for oral dosing) Most clients can absorb adequate amounts of vitamin B12 if large oral doses are given Give oral forms with food to enhance absorptio
What administration considerations apply to alteplase?	Administer via IV infusion. Give thrombolytic agents ASAP within onset of symptoms (less than 2 hr for MI, 3–4.5 hr for CVA). Obtain baseline platelet counts, Hgb, Hct, aPTT, PT, INR, and fibrinogen levels, and monitor periodically. Obtain baseline vit
What administration considerations apply to oprelvekin?	Obtain a baseline CBC with differential and platelet count plus measure serum electrolytes and monitor periodically thereafter Administer subcutaneously once daily 4 to 6 hr after chemotherapy. Continue therapy until platelet counts are above 50,000/mm3

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hematologic drugs