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Physiology Stack 2
| Question | Answer |
|---|---|
| What maintains the resting membrane potential of a neuron? | The sodium–potassium pump (Na⁺/K⁺-ATPase), which moves 3 Na⁺ out and 2 K⁺ in, creating an electrochemical gradient. |
| What event triggers the rapid depolarization phase of an action potential? | Voltage-gated sodium channels opening, allowing Na⁺ to enter the cell. |
| What is saltatory conduction? | The jumping of action potentials between nodes of Ranvier on myelinated axons, greatly increasing conduction velocity. |
| What causes repolarization in an action potential? | Opening of voltage-gated potassium channels and efflux of K⁺. |
| What determines the strength of a neural signal? | Frequency of action potentials, since amplitude is constant (all-or-none principle). |
| How does the sympathetic nervous system affect heart rate and blood pressure? | It increases both by releasing norepinephrine, which binds to β₁ receptors in the heart. |
| What neurotransmitter is released by parasympathetic postganglionic neurons? | Acetylcholine (ACh), which acts on muscarinic receptors. |
| What is the functional role of the hypothalamus? | It regulates homeostasis: temperature, hunger, thirst, circadian rhythms, and autonomic/endocrine integration. |
| What is sensory transduction? | Conversion of a physical stimulus (light, sound, chemicals) into an electrical signal in sensory receptors. |
| How do steroid hormones exert their effects? | By diffusing through the cell membrane and binding intracellular receptors that alter gene transcription. |
| How are peptide hormones transported in the blood? | They circulate freely (unbound) because they are water-soluble. |
| What feedback mechanism regulates most endocrine hormones? | Negative feedback loops that maintain stable internal conditions. |
| What determines cardiac output? | Heart rate × stroke volume. |
| What is the role of preload in cardiac function? | It stretches cardiac muscle fibers before contraction; increased preload enhances stroke volume (Frank–Starling law). |
| What physiologically causes the “lub-dub” heart sounds? | S1: closure of AV valves; S2: closure of semilunar valves. |
| What initiates the electrical conduction of the heart? | The sinoatrial (SA) node, the heart’s natural pacemaker. |
| What is the primary function of the lymphatic system? | To return interstitial fluid to the bloodstream and support immune surveillance. |
| What is the difference between innate and adaptive immunity? | Innate immunity is fast and non-specific; adaptive immunity is slower, highly specific, and involves memory. |
| How do cytotoxic T cells kill infected cells? | By releasing perforin and granzymes that induce apoptosis. |
| What drives oxygen diffusion from alveoli into blood? | A partial pressure gradient, with alveolar PO₂ higher than pulmonary capillary PO₂. |