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BIO II: Exam 4

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QuestionAnswer
Diffusion - NONPOLAR ONLY - Through cell membrane from HIGH to LOW concentrations - No ATP
Facilitated Diffusion - Polar molecules - Through Channels, Carriers, or Transporter Proteins - From HIGH to LOW concentrations - Passive Transport - NO energy required - Unique to a single molecule
Active Transport - Polar molecules - Through "Pumps" - Requires ATP - Can move AGAINST concentration gradient
Transport Proteins They're SPECIFIC and only allow specific molecules to pass through the cell membrane
True or False: Water can move freely through the cell membrane despite being polar TRUE, Aquaporins are a special transmembrane protein that transport water, allowing osmosis to take place
How do non-polar molecules move through blood? Blood carrier proteins move non-polar molecules through water-based blood
What are the two ways our bodies pass signals? 1. Nervous system * 2. Endocrine System *
Endocrine System • Rapid transmission of chemical signals that can be prolonged and communicate to many areas (targets) at once • Signals sent through blood stream • A network of glands that secrete HORMONES into the blood
Hormones chemical messengers that travel throughout the body in the blood
Hormone Function - Need to bind to receptors on target cells to cause a response - Receptors are hormone-specific proteins (structure --> function) - Not all cells have receptors for every hormone
What are the two different types of receptors, and what's different about them? 1. Extracellular Receptor: Binding site on the outside of the cell membrane (transmembrane proteins) 2. Intracellular Receptor: Binding site is inside the cell in the cytosol or in the nucleus
Signal Transduction (extracellular hormone receptors) A signal is sent into the cell, producing a response, without the molecule (hormone) ever physically entering the cell
Intracellular Hormone Receptors - Form a Hormone Receptor Complex (HRC) - HRC binds to DNA (acts like a promoter) - Turns on or off the expression (transcription) of genes
Tangent How hormones regulate genes
Transport vs Transduction Transport: Movement of a MOLECULE across a membrane Transduction: Passing of a MESSAGE across a membrane
Glucoregulation Glucose transport and signal transduction
What happens if there's too little blood glucose? Reduced muscular or cognitive function
What happens if theres too much blood glucose? Can lead to Type II diabetes
What are receptors, control centers, and effectors? Receptors: Receives information Control Centers: Where information is processed and orders sent out Effectors: Organ that actually changes the variable (EX: Home temp. -> Receptor: Thermometer, Control Center: Thermostat, Effector: AC/furnace)
What happens if someone is hyperglycemic? Insulin travels to liver - Blood glucose is turned into glycogen (polysaccharide- glucose storage molecule)
What happens if someone is hypoglycemic? Glucagon travels to liver - Glycogen turns into blood glucose
Glucagon, Glycogen, Glucose, GLUT-4 Glucagon - hormone, releases glucose Glycogen - polysaccharide (glucose storage molecule) Glucose - monomer GLUT-4 - glucose transporter (transmembrane protein)
Hypoglycemia vs Hyperglycemia HYPOglycemia: LOW blood sugar, glycogen --> glucose, GOAL is to INCREASE blood sugar HYPERglycemia: HIGH blood sugar, glucose --> glycogen, GOAL is to DECREASE blood sugar
Type I vs Type II diabetes Type I: Inability to PRODUCE insulin Type II: Inability to RESPOND to insulin
How can our bodies increase or decrease hormone responses? 1) Change the amount of hormone / # blood transport proteins 2) Change the # of receptors 3) Block (inhibit) / promote (activate) the binding of hormones to receptors 4) Produce counteracting / amplifying hormones
Stimulants vs Suppressants Stimulants: (+) INCREASE production in target Suppressants: (-) DEACREASE production in target
What happens when you add or reduce suppressants? Adding --> REDUCES hormone production Reducing --> INCREASES hormone production
Why are negative feedback loops important? - They maintain homeostasis - They prevent overproduction
Up-regulation vs Down-regulation Up-regulation: INCREASED # of receptors --> "AMPLIFIES" hormone effect Down-regulation: DECREASED # of receptors --> "DAMPENS" hormone effect
Sizes of the different hormones Amine - Small Peptide/protein - Large Steroid - Medium
What are the differences in the fate of glucose once it enters liver cells or muscle cells? Liver cells can release glucose back into the bloodstream to maintain blood sugar levels Muscle cells use glucose for their own energy needs and cannot release it directly
What are the two types of inhibitors? 1. Competitive inhibitor 2. NON-competitive (allosteric) inhibitor
What are the four different hormone interactions? 1. Additive Effect 2. Synergistic Effect 3. Permissive Effect 4. Antagonistic Effect
Additive Effect 2 hormones do the SAME thing
Synergistic Effect 2 hormones that do the same thing AMPLIFY the effect
Permissive Effect The FULL effect of one hormone only happens in presence of the second, hormones do NOT do the same thing
Antagonistic Effect One hormone opposes the action of another hormone
Is the matrix closed in mitochondria? YES, the matrix is CLOSED (IMPORTANT)
KNOW and be able to IDENTIFY different parts of a mitochondrion - Cristae (folds) - Mitochondrial matrix - Inner membrane - Outer membrane - Inter-membrane Space
What is the goal of metabolism? The breaking down of complex molecules to create the energy needed to sustain life (ATP)
What does respiration do? Converts glucose (chemical energy) to ATP (chemical energy)
What are the four parts of cellular respiration? 1. Glycolysis 2. Pyruvate processing 3. Citric Acid Cycle (Kreb's cycle) 4. Oxidative Phosphorylation
1. Glycolysis Breaks down SUGAR (glucose) - Occurs in CYTOSOL (liquid part of cytoplasm) - 1 glucose (6C) --> 2 molecules of pyruvate (3C molecule) - 2 (net) ATP from ADP is made and NAD+ is covered to NADH 1 glucose, 2 ADP, 2 NAD+ --> 2 pyruvate, 2 ATP, 2 NADH
Is step 1 of glycolysis showing an oxidation or reduction of glucose? Reduction
What is the evidence in knowing glycolysis is a reduction reaction? ATP is being oxidized, glucose GAINS a phosphate from ATP
2. Pyruvate Processing Pyruvate (cytoplasm) --> to Matrix --> Pyruvate Processing --> Acetyl-CoA
What is the purpose of the citric acid cycle (Kreb's cycle)? To oxidize acetyl-CoA and make electron carriers, to fully oxidize carbon and make NADH and FADH2
What is the ATP production in each step of respiration? 1. Glycolysis - 2 ATP 2. Pyruvate Processing - 0 ATP 3. Citric Acid Cycle (Kreb's) - 2 ATP 4. Oxidative Phosphorylation - 34 ATP (25-30)
What are the two parts of oxidative phosphorylation in respiration? 1. The ETC 2. ATP Synthase
What happens in an ETC? - High energy electrons enter - Protein subunits pass electrons from one to the next - As they lose energy, they pump H+ into the inter membrane space
What is the direct role of acetyl-CoA in cellular respiration? It is oxidized to provide energy to make NADH and FADH2
Created by: emily.zegarra
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