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Biochem Unit 1

What is an ionic bond? Transfer of electrons between atoms, creating charged ions. Ionic compounds are soluble in water.
What is a covalent bond? Sharing of electrons between atoms. Can be polar or nonpolar depending on electronegativity difference.
What is a polar covalent bond? A covalent bond with EN difference of 0.4–1.7. Polar molecules dissolve in water; nonpolar molecules do not.
What are intermolecular bonds? Attractions between molecules that affect solubility, brittleness, boiling and melting points.
What are hydrogen bonds? Strongest intermolecular force, weaker than covalent. Partial + H attracts partial – atom (O, N, F, C) in another molecule.
What is a dehydration reaction? A reaction where –OH of one molecule and H of another form H2O, while the molecules join with a covalent bond.
What is hydrolysis? A reaction where water is added to break a covalent bond, separating macromolecules.
Why is water the universal solvent? Water surrounds ions and polar molecules with hydration shells, stabilizing them and allowing dissolution.
What is the water lattice? In liquid water, H bonds form a lattice. Bonds break and reform quickly, allowing water to flow.
Why is ice less dense than water? Ice forms 4 hydrogen bonds per molecule, creating open crystalline spacing. Molecules are farther apart, so ice floats.
Why does water have high specific heat? Energy goes into breaking hydrogen bonds, so water resists temperature changes and stays liquid until 100 °C.
What is cohesion in water? Water sticks to itself via hydrogen bonds, causing surface tension. Lets insects walk on water and beads form on wax.
What is adhesion in water? Water sticks to other polar or charged objects by forming hydrogen bonds with them.
What is an aqueous solution? Water surrounds ions or polar molecules with hydration shells, where the slightly (-) surrounds the slightly (+) and vice versa, preventing them form rejoining the lattice
What are carbohydrates? Organic molecules with ratio C:H:O = 1:2:1. Categories: monosaccharides, disaccharides/oligosaccharides, polysaccharides.
What are monosaccharides? The simplest sugars. Differ by chain length and type of carbonyl group (aldehyde or ketone).
What is alpha glucose? Monosaccharide with –OH at C1 below the ring. Humans can digest alpha glucose.
What is beta glucose? Monosaccharide with –OH at C1 above the ring. Humans cannot digest beta glucose (fiber).
What are oligosaccharides? 2–3 simple sugars joined by 1–4 glycosidic linkages through dehydration synthesis.
What are disaccharides? Carbohydrates made of two monomers: maltose, lactose, sucrose.
What is maltose? A disaccharide of α glucose + α glucose. Found in grains and beer brewing.
What is lactose? A disaccharide of galactose + β glucose. Found in milk.
What is sucrose? A disaccharide of α glucose + fructose. Found in table sugar.
What are polysaccharides? 100+ monosaccharides linked by glycosidic bonds. Functions: energy storage (starch, glycogen) and structural support (cellulose, chitin).
What is starch? Main plant energy storage polysaccharide made of linked glucose molecules.
What is amylose? Form of starch that is unbranched, with α 1–4 links.
What is amylopectin? Branched form of starch. Main chain has α 1–4 links, branches have α 1–6 links.
What is glycogen? Animal energy storage in liver and muscle. Highly branched (α 1–4, α 1–6). Stores deplete in about one day.
What is cellulose? Structural polysaccharide in plant cell walls. β 1–4 links with alternating OH. Humans can’t digest it. its a straight chain like amylose, but you can recognise it by the alternating OH
What is glucosamine? Modified glucose molecule where an N-containing group replaces an OH group.
What is chitin? composed of glucosamine. Found in exoskeletons of beetles and creasteans. used in contact lenses and stitches.
What are lipids? Nonpolar molecules for long-term energy, insulation, cushioning, and storage.
What are fatty acids? Long hydrocarbon chains with a terminal carboxyl group that gives is acidic properties. Longer chains are more hydrophobic.
What are saturated fatty acids? Fatty acids with 4Hs bonded to C in single bonds (straight)
What are unsaturated fatty acids? Fatty acids with 3Hs bonded to C with one of them being a double bond ( bent at the double bond)
What are triglycerides? Fats with 3 fatty acids + glycerol. Formed by dehydration (ester linkages). Double the energy of carbs.
What are phospholipids? Amphipathic lipids with polar phosphate head + 2 nonpolar fatty acid tails. Main component of cell membranes, with ester and phosphate ester links to the glycerol
What are steroids? Lipids with 4 fused carbon rings + functional groups. Include cholesterol and sex hormones. gives molecule dual solubility properties
What is cholesterol? Steroid that maintains cell membrane fluidity and permeability. Prevents membranes from freezing.
What are waxes? Lipids made of long fatty acids + alcohols or carbon rings. Hydrophobic, firm, pliable. Ex: cutin, the water resistant coating on plants, bird feathers, beeswax.
What are the main roles of proteins? 50% of cell dry mass. Provide structure (keratin, collagen), act as enzymes, form antibodies, and transport O₂/CO₂.
What determines protein shape and why is it important? Shape is set by amino acid order and types. Shape is crucial for function; misfolding can cause disease.
What is the structure of amino acids? Central C bonded to amino, carboxyl, H, and an R group (20 types, 8 essential). Linked by peptide bonds via dehydration where the carboxyl of one links to the amino of the other
What are the four protein structure levels? Primary = amino acid chain. Secondary = α helix/β sheet via H bonds. Tertiary = 3D fold via R groups. Quaternary = multiple chains.
What are nucleic acids and their monomers? DNA and RNA, made of nucleotides (nitrogenous base, 5-C sugar, phosphate group).
What are the key features of DNA? Sugar = deoxyribose. Bases: A,T,G,C. Purines = A,G; pyrimidines = T,C. Double-stranded, antiparallel, A–T has 2 H bonds, G–C has 3.
What bonds hold DNA together? Phosphodiester bonds (covalent) link nucleotides 5’→3’ by dehydration where phosphate group at C5 bonds with the hydroxyl group at C3,Hydrogen bonds hold bases between strands.
What are the key features of RNA? Sugar = ribose. Single-stranded. Bases: A,U,G,C (uracil replaces thymine). Forms phosphodiester bonds but no H bonds.
What are enzymes and how do they work? Biological catalysts, reusable. Active site fits substrate (induced fit) to form enzyme–substrate complex.
What factors affect enzyme activity? More substrate = higher rate until saturation. Temp and pH have optimal ranges; extremes cause denaturation.
What is allosteric regulation and feedback inhibition? Allosteric activators fix active site; inhibitors distort it. Feedback inhibition: end product inhibits the first enzyme in a pathway.
Created by: sh_bookworm
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