Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

cbag ppp

QuestionAnswer
What is the Pentose Phosphate Pathway (PPP)? A metabolic pathway that converts Glucose 6-phosphate (G6P) into pentose phosphates, producing NADPH and CO₂.
What molecule is reduced to generate NADPH in the PPP and Why is NADPH important? Nicotinamide Adenine Dinucleotide Phosphate (NADP⁺) is reduced and it's essential for reductive biosynthesis (like fatty acid synthesis) and maintaining the reduced state of glutathione (antioxidant defense).
What happens in the oxidative stage of the PPP? Irreversible and controlled Involves oxidation, ring-opening, and oxidative decarboxylation Produces ribulose 5-phosphate, 2 NADPH, and 1 CO₂
What happens in the non-oxidative stage of the PPP? Reversible and uncontrolled Converts ribulose 5-phosphate into ribose 5-phosphate and xylulose 5-phosphate Generates other sugars essential for metabolism
Why is the PPP essential for cells? Generates NADPH for reductive biosynthesis (fatty acids, cholesterol) Provides ribose 5-phosphate for nucleotide synthesis (DNA/RNA) Maintains the reduced state of glutathione, protecting against oxidative stress
What happens in the oxidative stage of the PPP? Irreversible and controlled Involves oxidation, ring-opening, and oxidative decarboxylation Produces ribulose 5-phosphate, 2 NADPH, and 1 CO₂
What happens in the non-oxidative stage of the PPP? Reversible and uncontrolled Converts ribulose 5-phosphate into ribose 5-phosphate and xylulose 5-phosphate Generates other sugars essential for metabolism
What regulates the oxidative stage of the PPP? The ratio of NADP⁺ to NADPH, impacting G6PD activity (the control point)
What drives the non-oxidative stage of the PPP? The concentration of substrates/products—it adapts to cellular needs
What are the different modes of PPP operation? Mode 1: Equal need for NADPH & ribose 5-phosphate. Mode 2: More ribose 5-phosphate needed (like in rapidly dividing cells). Mode 3: Increased need for NADPH (e.g., in fat cells, lactating mammary glands).
What happens in Glucose 6-Phosphate Dehydrogenase (G6PD) deficiency? Reduced NADPH & glutathione levels. RBCs are more vulnerable to oxidative damage (can lead to hemolytic anemia). Triggered by oxidative stressors (e.g., certain drugs, fava beans).
What historical figure might have had G6PD deficiency? Pythagoras—warned against eating fava beans!
What are common triggers for oxidative stress in G6PD deficiency? Certain drugs (e.g., anti-malarials), infections, and fava beans.
How was G6PD deficiency linked to anti-malarial drugs? Observations in the 1950s showed adverse reactions in deficient individuals.
Why are fava beans a problem for people with G6PD deficiency? They contain compounds that increase oxidative stress, which G6PD-deficient individuals can't combat effectively.
Created by: REDZ17
Popular Biology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards