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Acid/base
patho
| Question | Answer |
|---|---|
| What is the equation for acid and base balance in the body? | CO2 + H20 <--> Carbonic acid <--> H+ + Bicarbonate |
| What is the normal pH range for blood? | 7.35-7.45 |
| Strong acids can be buffered by... | weak bases |
| What are 2 the volatile acids in our bodies? | Carbonic acid and CO2 |
| Carbonic acid dissociates into... | CO2 and water |
| What are 2 examples of non-volatile/fixed acids? | Ketones and lactic acid |
| How does our body get rid of volatile acids? | Lungs |
| How does our body get rid of non-volatile/fixed acids? | Kidneys |
| Describe the protein buffer system | Largest buffer system. Hemoglobin carries out this process. |
| Describe the carbonic acid-bicarbonate buffer system | Strongest buffer system, used by the lungs and the kidneys. Involves CO2, carbonic acid, hydrogen ions, and bicarbonate. |
| To lower the pH of the blood, the carbonic acid-bicarbonate buffer system will... | make CO2 combine with water to make carbonic acid to make blood more acidic |
| To elevate the pH of the blood, the carbonic acid-bicarbonate buffer system will... | Carbonic acid will dissociate into CO2 and water and CO2 will be released through the lungs |
| Hypocapnia means... | CO2 is below normal |
| Hypercapnia means... | CO2 is above normal |
| What are normal pCO2 levels? | 35-45 |
| What are normal HCO3 levels? | 22-26 |
| What are normal pO2 levels? | 80-100 |
| What are normal anion gap levels? | 8-16 |
| The anion gap is used for the assessment of... | acidosis |
| Define base excess/deficit: | measures all buffer systems of the blood |
| Changes in pH can affect the movement of these 2 electrolytes: | Potassium and Calcium |
| What does the body do when the blood is hyperkalemic? | H+ shifts out of cells leading to acidosis |
| What does the body do when the blood is hypokalemic? | H+ shifts into cells leading to alkalosis |
| What goes on during acidosis in regards to H+ and K? | H+ shifts into cells from the blood to increase pH, and K shifts out of cells into the blood to compensate for the change in charge. This leads to hyperkalemia |
| What goes on during alkalosis in regards to H+ and K? | H+ moves out of cells and into the blood to bring the pH down, K shifts into cells from the blood to compensate for the change in charge. This leads to hypokalemia |
| In respiratory acidosis, the blood is _____________ | hypercapnic |
| How do the kidneys compensate for respiratory acidosis? | excreting H+ and reabsorbing bicarbonate |
| How do the kidneys compensate for respiratory alkalosis? | reabsorbing H+ and excreting bicarbonate |
| How do the lungs compensate for metabolic acidosis? | increasing ventilation to get rid of excess CO2 |
| How do the lungs compensate for metabolic alkalosis? | decreasing ventilation to increase CO2 |
| How do the kidneys compensate for metabolic acidosis? | excreting H+ and reabsorbing bicarbonate |