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NURS 319 Exam 1

Chp 1/2 - Cellular Regeneration/Function Questions

QuestionAnswer
Homeostasis is lost when _________ occurs disease
What are the five major intracellular electrolytes? potassium, magnesium, phosphate, sulfate, bicarbonate
What are the two major extracellular electrolytes? sodium chloride and calcium
What process occurs when the mitochondrion doesn't get enough glucose? The mitochondrion will switch to ketones and lead to ketoacidosis
A build up of lactic acid in cells can lead to what? acidosis, sepsis, muscle cramps, etc.
The ______________ barrier regulates the growth and division of cells semi-permeable
What occurs in cellular dehydration? cellular fluid leaks out of the cell
What is on the outer surface of a cell and help with self vs non-self recognition? glycoproteins
What does the sodium-potassium pump establish? A resting membrane potential
which of the following need to be at a higher concentration within the cell to achieve appropriate cell function? sodium or potassium potassium
The sodium-potassium pump maintains ______ _________. fluid volume
How many sodium ions are pumped out of the cell? 3 sodium ions
How many potassium ions are pumped into the cell? 2 potassium ions
Why would one cell have more mitochondria than another cell? a cell with more mitochondria requires more energy than a cell with less mitochondria
Mitochondrial DNA comes from which parent? the mother
____ ________ may damage mitochondrial DNA. Free radicals
How much ATP is produced from aerobic metabolism? 34 ATP
How much ATP is produced from anaerobic metabolism? 2 ATP
(aerobic) Glucose goes through glycolysis to create _______ which then enters the ______ _______. pyruvate, Krebs cycle
(anaerobic) Glucose goes through _________ to create pyruvate which then becomes _______ _____. glycolysis, lactic acid
Which one occurs outside of the mitochondria? Anaerobic or aerobic metabolism Anaerobic metabolism
What are two etiologic causes of disease? genetic or bacteria
Etiologic agents can lead to ________ or _____________ changes in a cell. adaptive, maladaptive
How is allostasis triggered? through a neuroendocrine or hormonal response
Give an example of cellular adaptation. lung cells in people with asthma will remodel following a flare so as to avoid further damage
What is required for a histological examination? biopsy
What is the purpose of cellular adaptation? To maintain homeostasis
Differentiation of a cell can also be called _____________. maturation
Give an example of atrophy When someone breaks their arm and can't use it for long periods of time
What is an example of physiologic hypertrophy? bodybuilding
What is an example of pathologic hypertrophy? enlargement of the left ventricle due to aortic stenosis
Hypertrophy requires more blood flow and therefore stimulates _________________. angiogenesis
Hyperplasia occurs in cells capable of _________ ________. Give an example of this type of cell. miotic division, skin cells
Hyperplasia is in response to what? a stimulus
What is a physiological example of hyperplasia that occurs in women? Endometrial hyperplasia occurring from too much estrogen production
Metaplasia is the body's way of __________ itself from ______________. protecting, inflammation
What stage of cellular adaptation is a precursor to cancer? Dysplasia
Give an example of dysplasia in the body. cervical cells with warts due to HPV
What is the final stage of cellular adaptation before cells are considered cancerous? Anaplasia
What is the difference between anaplasia and neoplasia? Anaplasia is the progression of abnormal cells and marks when cells loose the ability to differentiate. Neoplasia is the complete unorganized, uncoordinated and uncontrolled cell growth resulting in cancer.
Neoplasia is seen in _______ or __________ tumors. benign, malignant
Which two stages of cellular adaptation are considered abnormal but do not point to cancer? Hyperplasia and Metaplasia
What characteristics differentiate between a benign and malignant tumor? A benign tumor has well-differentiated cells with a well defined border. A malignant tumor has undifferentiated cells with poorly defined boarders.
Which type of tumor spreads via metastasis? Malignant tumor
Name the first 5 of 10 causes of cellular injury. 1. Physical agents, radiation, or chemical 2. Dysfunction of Na-K Pump 3. Loss of plasma membrane integrity 4. Defects in protein synthesis 5. biologic agents (viruses, parasites), genetics
Name the second 5 of 10 causes of cellular injury. 6. Intracellular accumulations 7. Nutritional imbalances 8. Free radicals 9. Hypoxia 10. Immunological reactions
Which type of radiation is more harmful to the body? Ionizing or non-ionizing radiation? Ionizing radiation is capable of damaging DNA immediately
Abnormal accumulation of sodium in the cells is due to the dysfunction of what? The sodium-potassium pump
Give some examples of nutritional imbalances. Obesity, vitamin deficiency, anorexia
The endothelium secretes which three things? Vascular Endothelial Growth Factor (VEGF), nitric oxide (NO), endothelin
Injury to the endothelium can cause what? Atherosclerosis
Free radicals come from the environment. What is an example of a free radical? Cigarette smoke
Hyperlipidemia can cause what to occur in blood vessels? Atherogenesis
What is an example of physiological apoptosis? Ovaries in menopause
What type of disease can result from decreased apoptosis? Prostate cancer (too many prostate cells)
What type of disease can result from increased apoptosis? Spinal muscular atrophy, Alzheimer's disease
This irreversible process initiates inflammation and results in cell death. Necrosis
Infarction is also called __________ __________ Ischemic necrosis
What is an example of infarction? Myocardial infarction
Necrosis vs. Infarction Necrosis is the result of injury while Infarction is the result of long-term ischemia
Gangrene is caused by what bacteria? Clostridium perfringens
Frostbite is a form of _____ gangrene. dry
Created by: veerkabi
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