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NURS 319 Exam 1
Chp 1/2 - Cellular Regeneration/Function Questions
| Question | Answer |
|---|---|
| Homeostasis is lost when _________ occurs | disease |
| What are the five major intracellular electrolytes? | potassium, magnesium, phosphate, sulfate, bicarbonate |
| What are the two major extracellular electrolytes? | sodium chloride and calcium |
| What process occurs when the mitochondrion doesn't get enough glucose? | The mitochondrion will switch to ketones and lead to ketoacidosis |
| A build up of lactic acid in cells can lead to what? | acidosis, sepsis, muscle cramps, etc. |
| The ______________ barrier regulates the growth and division of cells | semi-permeable |
| What occurs in cellular dehydration? | cellular fluid leaks out of the cell |
| What is on the outer surface of a cell and help with self vs non-self recognition? | glycoproteins |
| What does the sodium-potassium pump establish? | A resting membrane potential |
| which of the following need to be at a higher concentration within the cell to achieve appropriate cell function? sodium or potassium | potassium |
| The sodium-potassium pump maintains ______ _________. | fluid volume |
| How many sodium ions are pumped out of the cell? | 3 sodium ions |
| How many potassium ions are pumped into the cell? | 2 potassium ions |
| Why would one cell have more mitochondria than another cell? | a cell with more mitochondria requires more energy than a cell with less mitochondria |
| Mitochondrial DNA comes from which parent? | the mother |
| ____ ________ may damage mitochondrial DNA. | Free radicals |
| How much ATP is produced from aerobic metabolism? | 34 ATP |
| How much ATP is produced from anaerobic metabolism? | 2 ATP |
| (aerobic) Glucose goes through glycolysis to create _______ which then enters the ______ _______. | pyruvate, Krebs cycle |
| (anaerobic) Glucose goes through _________ to create pyruvate which then becomes _______ _____. | glycolysis, lactic acid |
| Which one occurs outside of the mitochondria? Anaerobic or aerobic metabolism | Anaerobic metabolism |
| What are two etiologic causes of disease? | genetic or bacteria |
| Etiologic agents can lead to ________ or _____________ changes in a cell. | adaptive, maladaptive |
| How is allostasis triggered? | through a neuroendocrine or hormonal response |
| Give an example of cellular adaptation. | lung cells in people with asthma will remodel following a flare so as to avoid further damage |
| What is required for a histological examination? | biopsy |
| What is the purpose of cellular adaptation? | To maintain homeostasis |
| Differentiation of a cell can also be called _____________. | maturation |
| Give an example of atrophy | When someone breaks their arm and can't use it for long periods of time |
| What is an example of physiologic hypertrophy? | bodybuilding |
| What is an example of pathologic hypertrophy? | enlargement of the left ventricle due to aortic stenosis |
| Hypertrophy requires more blood flow and therefore stimulates _________________. | angiogenesis |
| Hyperplasia occurs in cells capable of _________ ________. Give an example of this type of cell. | miotic division, skin cells |
| Hyperplasia is in response to what? | a stimulus |
| What is a physiological example of hyperplasia that occurs in women? | Endometrial hyperplasia occurring from too much estrogen production |
| Metaplasia is the body's way of __________ itself from ______________. | protecting, inflammation |
| What stage of cellular adaptation is a precursor to cancer? | Dysplasia |
| Give an example of dysplasia in the body. | cervical cells with warts due to HPV |
| What is the final stage of cellular adaptation before cells are considered cancerous? | Anaplasia |
| What is the difference between anaplasia and neoplasia? | Anaplasia is the progression of abnormal cells and marks when cells loose the ability to differentiate. Neoplasia is the complete unorganized, uncoordinated and uncontrolled cell growth resulting in cancer. |
| Neoplasia is seen in _______ or __________ tumors. | benign, malignant |
| Which two stages of cellular adaptation are considered abnormal but do not point to cancer? | Hyperplasia and Metaplasia |
| What characteristics differentiate between a benign and malignant tumor? | A benign tumor has well-differentiated cells with a well defined border. A malignant tumor has undifferentiated cells with poorly defined boarders. |
| Which type of tumor spreads via metastasis? | Malignant tumor |
| Name the first 5 of 10 causes of cellular injury. | 1. Physical agents, radiation, or chemical 2. Dysfunction of Na-K Pump 3. Loss of plasma membrane integrity 4. Defects in protein synthesis 5. biologic agents (viruses, parasites), genetics |
| Name the second 5 of 10 causes of cellular injury. | 6. Intracellular accumulations 7. Nutritional imbalances 8. Free radicals 9. Hypoxia 10. Immunological reactions |
| Which type of radiation is more harmful to the body? Ionizing or non-ionizing radiation? | Ionizing radiation is capable of damaging DNA immediately |
| Abnormal accumulation of sodium in the cells is due to the dysfunction of what? | The sodium-potassium pump |
| Give some examples of nutritional imbalances. | Obesity, vitamin deficiency, anorexia |
| The endothelium secretes which three things? | Vascular Endothelial Growth Factor (VEGF), nitric oxide (NO), endothelin |
| Injury to the endothelium can cause what? | Atherosclerosis |
| Free radicals come from the environment. What is an example of a free radical? | Cigarette smoke |
| Hyperlipidemia can cause what to occur in blood vessels? | Atherogenesis |
| What is an example of physiological apoptosis? | Ovaries in menopause |
| What type of disease can result from decreased apoptosis? | Prostate cancer (too many prostate cells) |
| What type of disease can result from increased apoptosis? | Spinal muscular atrophy, Alzheimer's disease |
| This irreversible process initiates inflammation and results in cell death. | Necrosis |
| Infarction is also called __________ __________ | Ischemic necrosis |
| What is an example of infarction? | Myocardial infarction |
| Necrosis vs. Infarction | Necrosis is the result of injury while Infarction is the result of long-term ischemia |
| Gangrene is caused by what bacteria? | Clostridium perfringens |
| Frostbite is a form of _____ gangrene. | dry |