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USMLE2 Medicine 11
Infectious Disease - Abx
Question | Answer |
---|---|
most common cause of osteomyelitis | staph aureus (in sickle cell, it's salmonella) |
most common cause of pyelonephritis | E. coli |
B-lactamase resistant PCN's (4) | OX with two clocks (Di CLOX) around its neck holding a NAFta sign. oxacillin, cloxacillin, dicloxacillin, nafcillin. |
when should you use B-lactamase resistant PCN? | oxacillin, cloxacillin, dicloxacillin, nafcillin. When want Staph (not MRSA) coverage but G- is NOT suspected. |
Which organisms do the B-lactamase resistant PCN's cover? | All Staph, some Strep: S. PNA, S. viridans, GAS, GBS. VBAP |
Tx MRSA with what abx? (2) | Vanc or linezolid |
what do PCN G/amox/ampicillin cover? | Strep and G- |
cephalexin (Keflex) - what is it and what does it cover? | first gen cephalosporin, G+ coverage |
if minor G+ infection and PCN allergic, what abx to use? | clarithromycin/azithromycin or levofloxacin |
if serious G+ infection and PCN allergic, what abx to use? | vanc or linezolid |
name 3 macrolides. what do they cover? | ACE: azithro, clarithro, erythro. G+, but not serious staph infections. |
what does levofloxacin cover? | fluoroquinolone, covers Strep (inc S. PNA) |
does ciprofloxacin cover Strep PNA? | no |
what is the only oral med against MRSA | linezolid |
what can you use on vanc-resistant enterococci (G+)? | linezolid |
piperacillin & ticaricillin. what are they and what do they cover? | PCNs that cover G- (inc Enterobacteriaceae) and Pseudomonas |
Bacteria in family Enterobacteriaceae, G- or G+? | G- PEEKS: E.coli, Proteus, Enterobacter, Serratia, Klebsiella. |
infection where you want to cover G-, Pseudomonas, and Staph | Piperacillin + tazobactam (B-lactamase inhibitor) OR ticarcillin + clavulanate |
CTX is what kind of abx? what does it cover? | 3rd gen cephalosporin G- and S. PNA for PNA or meningitis |
Ceftazidime is what kind of abx? | 3rd gen cephalosporin |
What do 3rd gen cephalosporins cover? | G- |
cephalosporins that cover Pseudomonas | Ceftazidime (3rd gen ceph) and cefepime (4th gen) |
Cefepime - what kind of abx, and what does it cover? | 4th gen cephalosporin, covers G-, staph, and pseudomonas |
Which abx cover Pseudomonas? | piperacillin, ticarcillin, ceftazidime, cefepime, ciprofloxacin |
What is the first line drug for empiric PNA tx? | Levofloxacin (or cipro if you want Pseudomonas coverage) because fluoroquinolones also cover mycoplasma, chlamydia, and legionella |
gentamicin is what kind of abx and what does it cover? | aminoglycoside, covers G- |
what abx to cover anaerobes? | metronidazole, clindamycin less effective |
first line tx for c.diff | metronidazole |
to tx anaerobes in the mouth | clindamycin |