Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Session 4 Pharm- 2
Pharm -2- Opioids
| Question | Answer |
|---|---|
| What is the difference between opiate and opioid | opiate is naturally derived drug from opium (morphine and Codeine) a opioid is a drug natural or synthetic with morphine like qualities |
| A drug with addictive properties that can produce analgesic and sedative effects is termed what | narcotic |
| What are the functional classifications of opioids | Agonist, Antagonist, Agonist/antagonist and other |
| What type of drug is Fentanyl (Sublimaze, Duragesic) | Strong Opioid Agonist |
| What type of drug is alfentanil, remifentanil and sufentanil | strong opioid agonist used for anesthesia related to fentanyl |
| What type of drug is heroin | Strong Opioid Agonist that has no medical use |
| What type of drug is Hydromorphone (Dilaudid) | Strong Opioid Agonist |
| What type of drug is Meperidine (Demerol) | Strong Opioid Agonist |
| What type of drug is methadone | Strong Opioid Agonist |
| What type of drug is Morphine Sulfate (MS Contin) | strong opioid agonist |
| What type of drug is Codeine (Robitussin AC) | Moderate Opioid Agonist |
| What type of drug is Oxycodone (OxyContin) | Moderate Opioid Agonist |
| What type of drug is Hydrocodone | Moderate Opioid Agonist |
| Tylenol | 2,3,4 are combos of what drugs |
| Vicodin and Lortab combine what drugs | acetaminophen/hydrocodone |
| Vicoprofen combines what drugs | Ibuprofen/Hydrocodone |
| Percocet is a combo of what drugs | acetaminophen/Oxycodone (class II schedule drug) |
| What type of drug is Loperamide (Imodium) | weak opioid agonist |
| What type of drug is Diphenoxylate (Lomotil) | Weak opioid Agonist combined with atropine |
| What type of drug is Propoxyphene (Darvon | Weak Opioid Agonist combined with acetaminophen |
| What type of drug is Dextromethorphan (Delsym, Robitussin DM) | Weak Opioid Agonist |
| What type of opioid is Tramadol (Ultram( | Classified as Other opioid |
| What type of drug is Pentazocine (Talwin | Opioid Agonist/antagonist |
| What type of drug is Nalbuphine (Nubain) | Opioid Agonist/antagonist |
| What type of drug is Butorphanol (Stadol) | Opioid Agonist/antagonist |
| What type of drug is Naloxone (Narcan) | Opioid Antagonist |
| What Type of drug is Naltrexone (ReVia) | Opioid Antagonist |
| Define a schedule I controlled substance | no medical use high addiction potential (Heroin) |
| Define a schedule II controlled substance | medical use but has high addiction potential (strong and moderate opioid agonists) |
| Define a Schedule III controlled substance | Medical Use potential for dependence (Lortab, Tylenol |
| Define a Schedule IV controlled substance | Medical Use low abuse potential (Weak Opioid agonists) |
| What are the 5 types of opioids receptors | Mu "reap, Kappa "Sam", Delta, Epsilon, Sigma |
| What is the Mu opioid receptor associated with in regards to opioids tx | REAP- respiratory depression, euphoria, analgesia, physical dependence |
| What is the kappa opioid receptor associated with in regards to opioid tx | SAM- Sedation, Analgesia, Miosis |
| What are the endogenous Opioids | Endorphins, Dynorphins, Enkephalins |
| T/F the highest number of opioid MU receptors are found in the cerebral cortex | T |
| Pain can be modified anywhere along the pain pathway where are the three main sites for opioids to exert their analgesic effects | Spinal Cord, Thalamus and Limbic System, Brainstem |
| Opioids blocking pain in the spinal cord are typically modifying ascending pain signal (afferent) or Efferent pain signal | Inhibit release of neurotransmitters in spinal cord form afferents |
| What are the contraindications for using morphine | respiratory compromise, Asthma, Intracranial injuries, Paralytic Ileus |
| What are the adverse effects of morphine | euphoria, dysphoria, respiratory depression, Nausea, Constipation, sedation, pruritis, urticaria, bronchospasm, urinary retention, anxiety, hypotension. |
| What schedule is morphine | schedule 2 |
| What receptors does morphine act on | Mu (REAP- respiratory depression, euphoria, analgesia, physical dependence), Kappa (SAM- Sedation, Analgesia, Miosis) |
| What options exists for route of delivery of morphine | PO, IV, SC, IM, PR |
| What type of pain is morphine most effective on | visceral pain |
| T/F morphine could potentially be given to suppress a cough | T |
| What effect does morphine have on the skin | it causes histamine release and causes pruritis |
| What effects does morphine have on the lungs besides respiratory depression | Bronchospasm avoid use in asthmatics |
| If you give morphine to stop pain during labor what could you cause | prolongation of labor because it effects contractions of the uterus |
| What is the half life of morphine | 2.5- 3 hours lose 90% in the first day |
| What is the clinical uses for Methadone | absorbed well orally used in maintenance program for narcotic dependence treatment and powerful pain reliever |
| Why is Meperidine (Demerol) a good pain relief choice for patients with biliary disease | it does not constrict the sphincter of Odi |
| When is Meperidine (Demerol) contra indicated | pts receiving MAOI |
| How much more potent is Fentanyl than morphine | 80-100 times |
| Fentanyl comes in a dermal formula (Duragesic) what are some concerns with using this route | Easy overdose potential if pt forgets to take of previous patch and puts another one on (especially elderly) |
| What are some common uses for Fentanyl (Sublimaze, Duragesic) | Used in epidurals, and transdermally (Duragesic) for chronic pain patients |
| Apart from analgesia what positive effects does Codeine have | antitussive |
| T/F Codeine has a high abuse potential | F it rarely produces dependence |
| T/F propoxyphene a derivative of methadone is equal to aspirin in its analgesic effects | T so there is no real reason to prescribe in place of aspirin except for maybe when you are worried about aspirin toxicities |
| What other drugs do you want to avoid giving with Tramadol (Ultram) | antidepressants Tramadol inhibits serotonin and norepi uptake like the antidepressants and can cause serotonin syndrome if combined |
| What is the clinical use for Dextromethorphan | antitussive |
| What is the clinical use for loperamide (Imodium and Diphenoxylate (Lomotil) | Antidiarrheal |
| What is the use for buprenorphine (Subutex) | it is a partial agonist and can be used for outpatient opioid detox |
| What is the only benefit of using the opioid agonist/antagonists pentazocine (Talwin), Nalbuphine (Nubain) and Butorphanol (Stadol) | They don't cause respiratory depression |
| What use do Naloxone (Narcan) and Naltrexone (ReVia) have | they are opioid antagonists and can dramatically and completely reverse the effects of opioids |
| What is one concern of using Naltrexone (ReVia) long term to treat addiction | it is very hepatotoxic |
| Which has a longer half life Naloxone (Narcan) or Naltrexone (ReVia) | Naltrexone (ReVia) has a half life of about 48hrs; Narcan 1-2hrs |
Created by:
smaxsmith
Popular Science sets