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Bio Defs Week 2
Textbook Definitions
| Term | Definition |
|---|---|
| Lipid | Fatty macromolecule that are soluble in organic solvents and insoluble in water, fats, oils, waxes, steroids & phospholipids |
| Hydrocarbons | Organic molecule that contains only hydrogen & carbon atoms |
| Fatty Acids | Lipid w/ a hydrocarbon chain bonded at one end to a carboxyl group, stores chemical energy |
| Saturated | Lipids w/ only Carbon - Carbon single bonds, high melting points |
| Unsaturated | Lipids w/ at least one Carbon - Carbon double bond, causes links in the hydrocarbon chain, low melting point |
| Waxes | Long chains of non-polar lipid, fatty acids or long chain alcohols, solid |
| Oil | Polysatured fat that is liquid at room temperature |
| Steroids | Lipid w/ four-ring hydrocarbon structure, hormones, muscles, & immune system |
| Fats | Lipids w/ three fatty acid molecules, insulation, long-term energy storage |
| Glycerol | Three carbon molecules that form the “backbone” of phospholipids & fats |
| Ester Linkage | Covalent bond, condensation reaction b/tw carboxyl & hydroxyl groups, joins fatty acids and glycerol to form a fat or phospholipid |
| Phospholipids | Lipids w/ hydrophilic head & hydrophobic tail, major component for plasma membrane and organelle membrane |
| Amphipathic | Substances w/ hydrophilic & hydrophobic regions, “dual-sympathy” |
| Amino Acids | Small organic molecules that is the fundamental building block for protein, side chain |
| R-Group or Side Chain | The part of an amino acid that makes different variations |
| Hydrophilic | Active interaction w/ water, usually polar compounds w/ partial or fully charged atoms |
| Hydrophobic | uninterested in interaction w/ water, usually nonpolar compounds |
| Peptide Bond | Covalent bond formed by a condensation reaction b/tw two amino acids |
| Primary Structure | Sequence of amino acids in a polypeptide chain, unfunctional, protein 1st stage |
| Secondary Structure | Folding and coiling of primary structure, repeating configuration, alpha helix and beta pleated sheets, unfunctional, protein 2nd stage |
| Alpha Helix | Second structure in a protein, polypeptide backbone spiral shape, h-bonds |
| Beta Pleated Sheet | Second structure in protein, polypeptide backbone, folds into sheet-like shape, h-bond |
| Tertiary Structure | 3-D interaction b/tw amion acid chain and R group, mutli-bonds, built from secondary structure, weaves and coils around, protein 3rd stage |
| Disulfide Bonds | “Two sulfur” covalent bond, typically in the side chains, contribute to tertiary & quaternary levels |
| Quaternary Structure | Result from aggregation of two or more polypeptide subunits, big from multi-little |
| Macromolecular Machines | Group of proteins and nucleic acid that assemble to carry out a particular function |
| Polypeptide | Amino acid chain > 50 residues, “many peptide” |
| Oligopeptide | Amino acid chain < 50 residues, “few peptide”, aka peptide |
| Denatured | Protein or nucleic acid, loss of 3-D structure due to breakage of covalent &/or non-covalent bonds, heat, chemical, PH, or salt |
| Molecular Chaperons | Protein that facilitates folding or refolding into a 3-D shape |
| Prions | Infectious particles made up of protein, two different fold shapes, normal fold & disease fold, infected can infect the uninfected |
| Catalysis | Acceleration of a chemical reaction by adding a catalyst, usually an enzyme, activation energy |
| Catalyst | Any substance that increases the rate of a chemical reaction w/o itself undergoing any permeate chemical change |
| Enzyme | Protein catalyst used by living organisms to increase the rate of biological reactions |
| Substrates | 1) a reactant that interacts w/ a catalyst, 2) Surface on which a cell or organism sits |
| Active Site | Location on an enzyme molecule where substrates bind & react |
| Nucleic Acid | Macromolecule composed of nucleotide monomers, store & transfer hereditary information, includes DNA & RNA |
| Nucleotides | Building block of nucleic acid, nitrogen base, sugar (deoxyribose and ribose), and phosphate group, is comparable w/ nucleoside, but with more phosphate groups |
| Purines | Class of double-ringed nitrogenous bases (A, G), found in nucleotides |
| Pyrimidines | Class of single-ringed nitrogenous bases (C, U, T), found in nucleotides |
| Phosphodiester Linkage | Chemical link b/tw adjacent nucleotide residues in DNA & RNA, forms when a phosphate group of a nucleotide condenses w/ the hydroxyl group on the sugar of a different nucleotide, phosphodiester bond |
| Ribonucleotides | A nucleotide that contains ribose and a pentose sugar, is the basic building block for RNA |
| Deoxyribonucleotides | A nucleotide that contains a deoxyribose and a pentose sugar, is the basic building block for DNA |
| X-Ray Crystallography | Technique for determining 3-D structure of larger molecules, protein and nucleic acid, analysis diffraction patterns produced by x-ray beamed at crystals of the molecule |
| Antiparallel | Two strands of a molecule, nucleic acid, are parallel but run in opposite directions |
| Complementary Base Pairing/ Watson-Crick Pairing | Specific interactions between nitrogenous bases in DNA, A always pairs to T, and C always to G |
| Base Stacking | Arrangement of nitrogen bases in DNA, bases stack on top of each other in a parallel configuration |
| Template Strand | Original strand used as a base for a complementary strand, DNA synthesis |
| Complementary Strand | New strand of DNA that connects to a temple strand, DNA synthesis |
| Ribozymes | Any RNA Molecule that catalyses a chemical reaction |
| Condensation Reactions/Dehydration Synthesis | Reaction w/ two or more molecules to form a larger molecule, reaction loses water |
| Hydrolysis | Reaction to break down molecule by using water |