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Pharm chapters 24/25
Antiflammatory Drugs and Opiods/Non-opiod Analgesics
Question | Answer |
---|---|
Cox 1 Enzyme | Protects stomach lining and regulates blood platelets. |
cox 2 Enzyme | Triggers Inflammation |
What do NSAID's do? | Inhibits biosynthesis of prostaglandinsAnalgesic EffectAntipyretic Effect |
1st generation NSAIDs | Aspirin |
2nd generation NSAIDs | Cox 2 Inhibitors |
Salicylate level | 10-30 |
Toxic Salicylate level | >30 |
Most common s/e of salicylates | GI upset |
Cox 2 inhibitors blocks what | inflammation & pain release |
Cox 2 are prescrip/non-presc. drugs | prescriptions |
DMARD | Disease Modifying Antirheumati Drugs |
DMARDs ar use for | Rheumatoid Arthritis |
Immunomodulator Drugs (TNF blockers) | Enbrel, remicade, Humira |
Pt's taking TNF's ae prone to what | infection |
Anti-Gout Drugs | Colchicine, Uric Acid Inhibitors, Uricosurics |
Colchicine inhibits migration of what to inflamed sites? | leukocytes |
Main drug for uric acid inhibitor? | Allopurinol |
Main Uricosurics drug | Benemid |
Uricosurics blocks what? | reabsorption of uric acid & increases uric acid excretion |
Highest priority for the client with gout who is taking Colchicine. | Avoid alcohol and caffeine |
Non-opiod Analgesics | NSAID's that are used for Mild to Moderate pain |
Max. dose of acetaminophen/day | 4g |
Main Non-Opiod | Tylenol |
Narcotics | Opiods that are used for moderate to severe pain |
s/e of demerol | Othostatic Hypotension |
s/e of Opiate Analgesics | Respiratory depression |
Non-Opiods act where? | Peripherally - at site of injection or inflamation |
Opiods act where? | CNS |
Opiod Agonist | Nubain (binds with opiate receptor & increases pain threshhold |
Opiod Antagonist | Narcan (must be monitored continuously) |
What program is for opiod-addicted people? | Methadone tx. program |
Reverses resp. depression in a pt. receiving morphine via pca pump and who has resp. of 10? | Narcan |
s/e of morphine | Urinary retention, constipation, hypotension, & decreased resp. rate |