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Pharm chapters 24/25

Antiflammatory Drugs and Opiods/Non-opiod Analgesics

QuestionAnswer
Cox 1 Enzyme Protects stomach lining and regulates blood platelets.
cox 2 Enzyme Triggers Inflammation
What do NSAID's do? Inhibits biosynthesis of prostaglandinsAnalgesic EffectAntipyretic Effect
1st generation NSAIDs Aspirin
2nd generation NSAIDs Cox 2 Inhibitors
Salicylate level 10-30
Toxic Salicylate level >30
Most common s/e of salicylates GI upset
Cox 2 inhibitors blocks what inflammation & pain release
Cox 2 are prescrip/non-presc. drugs prescriptions
DMARD Disease Modifying Antirheumati Drugs
DMARDs ar use for Rheumatoid Arthritis
Immunomodulator Drugs (TNF blockers) Enbrel, remicade, Humira
Pt's taking TNF's ae prone to what infection
Anti-Gout Drugs Colchicine, Uric Acid Inhibitors, Uricosurics
Colchicine inhibits migration of what to inflamed sites? leukocytes
Main drug for uric acid inhibitor? Allopurinol
Main Uricosurics drug Benemid
Uricosurics blocks what? reabsorption of uric acid & increases uric acid excretion
Highest priority for the client with gout who is taking Colchicine. Avoid alcohol and caffeine
Non-opiod Analgesics NSAID's that are used for Mild to Moderate pain
Max. dose of acetaminophen/day 4g
Main Non-Opiod Tylenol
Narcotics Opiods that are used for moderate to severe pain
s/e of demerol Othostatic Hypotension
s/e of Opiate Analgesics Respiratory depression
Non-Opiods act where? Peripherally - at site of injection or inflamation
Opiods act where? CNS
Opiod Agonist Nubain (binds with opiate receptor & increases pain threshhold
Opiod Antagonist Narcan (must be monitored continuously)
What program is for opiod-addicted people? Methadone tx. program
Reverses resp. depression in a pt. receiving morphine via pca pump and who has resp. of 10? Narcan
s/e of morphine Urinary retention, constipation, hypotension, & decreased resp. rate
Created by: ReginaK
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