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Pharm F Analgesics
| Question | Answer |
|---|---|
| Opioids education | For moderate or severe acute pain, intractable pain 2 cancer Schedule 2 (high abuse potential, possible severe dependence) No ceiling effect (more drug = more analgesia) |
| Opioids expected ADRs | N/V, constipation itching pinpoint pupils orhtostatic hypotension dependence |
| Opioids serious ADRs | Respiratory depression Sedation Hypotension, bradycardia urinary retention biliary colic Cerebral vasodilation |
| Naloxone education | Opioid antagonist Will likely need repeat dose IV preferred, IM, SQ, intranasal Check them every 30 minutes |
| Naloxone ADRs | Vomiting Reversal of analgesia Tachycardia, HTN, v-tach, tachypnea Acute withdrawal (cramping, N/V, anxiety, chills, hot flashes, rhinorrhea. diarrhea) |
| Methadone education | Used for relief of moderate-severe pain, treatment of opioid dependence, relief of labor pain Low potential for abuse, less resp depression, less analgesia than opioids Avoid ETOH and other CNS depressants Has a ceiling effect |
| Methadone ADRs | Dizziness, sedation, headache, respiratory depression Abstinence sydndrome (cramping, HTN, vomiting, fever, anxiety) |
| Ibuprofen education | Admin w/ food or milk 1-2 weeks for arthritis Contraindicated w/ warfarin, ETOH Check stools for occult blood Often added with opioids |
| Ibuprofen ADRs | GI distress, renal dysfunction Increased BUN, creat, decreased UOP Increased risk of MI/stroke Garlic and ginger increase risk of bleeding |
| Acetaminophen education | No anti-inflammatory properties Antidote - acetylctysteine Avoid alcohol use No effects of platelets aggregation Often added with opioids |
| Acetaminophen ADRs | Hepatotoxicity (max 4g/ day - adults) |
| Benzos education | Skeletal muscle relaxants Used for (cerebral palsy, MS, spinal cord injury) Route (PO, IV, IM) Dependence with long time use |
| Benzos ADRs | CNS depression Respiratory depression |
| Ketorolac education | NSAID Short-term For moderate-severe acute pain, usually post-op Used in combo with opioids Routes (PO, nasal, IV, IM) |
| Ketorolac ADRs | GI bleeding Renal dysfunction |
| NSAID | Aspirin Ibuprofen Ketorolac Naproxen |
| Raloxifene education | Treats and prevents osteoporosis after menopause Decrease risk of breast cancer after menopause |
| Raloxifene ADRs | hot flashes, flu-like symptoms muscle spasms, arthralgia (joint pain) Infection DVT insomnia |
Created by:
Haydenmeh
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