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Microbio Ch.6
| Question | Answer |
|---|---|
| Why are acellular pathogens called so? Are they considered living? | They are not composed of cells/ Not living |
| Understand the characteristics of viruses. (slide 2) | DNA or RNA/ Capsid, envelope, or both/ Spikes/ Shapes: Helical, polyhedral, complex/ Needs to infect host to reproduce/ Acellular |
| What does it mean that viruses are obligate, intracellular parasites? | Must infect a host to reproduce/ Narrow host range |
| What is meant by a "narrow host range?" | Virus can either infect a human or a different species, but not both/ Not multiple different cells or organs |
| Define: capsid | Always surrounded by a protein coat |
| Define: envelope | Sometimes surrounded by a phospholipid membrane |
| What are the three main parts of a virus? | DNA or RNA/ Capsid/ (Sometimes) Envelope |
| Define: naked virus | Protein coat only |
| Define: enveloped virus. | Contain capsid and envelope |
| What are spikes and why are they significant? | Glycoprote9in extension of the capsid or envelope/ Attaches virus to other cells |
| How are viruses classified? What do ds and ss stand for? | By the type of DNA or RNA found within the capsid of the virus// Single stranded virus |
| What do we mean when we say that viruses "hijack" host cells? | Uses all of the hosts cell machinery to replicate |
| Understand the lytic cycle, including attachment | The phage attaches to the surface of the host |
| Understand the lytic cycle, including penetration | The viral DNA enters the host cell |
| Understand the lytic cycle, including biosynthesis | Phage DNA replicates and phage proteins are made |
| Understand the lytic cycle, including maturation | New phage particles are assmebled |
| Understand the lytic cycle, including lysis | The cell lyses, releasing eh newly made phages |
| Understand the lysogenic cycle. What makes it different from the lytic cycle? | Phage DNA incorporated into the host gnome/ Cells divide and prophage does too/ then the prophage enters the lytic cycle |
| What does temperate mean in relation to the lysogenic cycle? | Becomes part of the hose cell chromosome/ |
| Understand how viruses with animal hosts are different from bacteriophages 1-3 | Attachment/ Penetration. Cell engulfs virus by endocytosis/ Uncoating |
| Understand how viruses with animal hosts are different from bacteriophages 4-6 | Biosynthesis. Viral RNA enters nucleus, replicates by the viral RNA polymerase/ Assembly/ Release. the cell is not killed and continues to make new virus |
| What is uncoating? | Viral contents are released by breaking envelope |
| Define different types of infections and examples of each: persistent | Virus stays in certain tissues or organs of infected person// Herpes, Hepatitis C, HIV |
| Define different types of infections and examples of each: latent | Virus stays hidden or dormant inside the cell// Chicken pox-Shingles |
| Define different types of infections and examples of each: chronic. | Disease with symptoms that are recurrent or persistent over a long time// HIV |
| Understand the basics of viroids | Short strand of circular RNA/ No protein coat |
| Understand the basics of prions. | Infectious protein particle/ Caused by genetic mutation or spontaneously forms/ Responsible for transmissible spongiform encephalopathy. Ex. Kuru, Creutzfeldt-Jakob, and Mad Cow Disease |