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Session 3 Pharm- 10

Pharm -10- protein synthesis inhibitors 2

QuestionAnswer
What type of drug is Gemifloxacin (Factive) Fluoroquinolone (DNA synthesis inhibitor)
What type of drug is Moxifloxacin (Avelox) Fluoroquinolone (DNA synthesis inhibitor)
What type of drug is Levofloxacin (Levaquin) Fluoroquinolone (DNA synthesis inhibitor)
What type of drug is Ciprofloxacin (Cipro) Fluoroquinolone (DNA synthesis inhibitor)
What type of drug is Ofloxacin (Floxin) Fluoroquinolone (DNA synthesis inhibitor)
What type of drug is Lomefloxacin (Maxaquin) Fluoroquinolone (DNA synthesis inhibitor)
What type of drug is Norfloxacin (Noroxin) Fluoroquinolone (DNA synthesis inhibitor)
What type of bacteria does Ciprofloxacin cover covers lesser and great gram negatives, 1 of 2 fluoroquinolones for pseudomonas (other is levofloxacin) and covers atypicals
What type of coverage do you get from levofloxacin covers gram + (not MRSA), enterococcus faecalis and pseudomonas, some anaerobes, and the atypicals
What region of the body is Cipro generally associated with tx below the waist good for UTIs, STDs
What region of the body are the 3rd generation fluoroquinolones associated with tx above the waist or respiratory FQs
What two fluoroquinolones would you not prescribe for UTIs moxifloxacin and Gemifloxacin
Which Fluoroquinolone is prescribed for tx of anthrax Ciprofloxacin
Do you have to adjust dosage in renally impaired pt when giving fluoroquinolones yes
What education do you have to give pt about drug interactions when taking fluoroquinolones forms complexes with metallic ions so avoid taking them with antacids, multivitamins or food that has metals in it
What are the major s/e of the fluoroquinolones Hypo/Hyperglycemia, CNS effects, cartilage damage (avoid in pregnancy), QTc prolongation, tendon rupture (elderly), Rash
What type of drug is Bactrim sulfamethoxazole and trimethoprim combo
What is the place in therapy for Bactrim acute uncomplicated cystitis (first line), Pneumocystis jiroveci (PCP and PJP pneumonia), Also may be useful for CA and HA MRSA
What are some of the major s/e of using Bactrim urticaria to anaphylaxis rxn, Rash can be mild to fatal SJS. N/V/D, myelosuppression, Hyperkalemia, increase in Scr
What are the three regimens recommended for latent TB infection Isoniazid x9 months or 6 months or rifampin x4 months
What is the tx protocol for active TB 2 months using 4 drugs then 4-7months with 2 drugs (combinations can be varied and complicated depending on resistance)
What type of drug is isoniazid (INH) major first line drug for tx of TB
What type of drug is Rifampin (RIF) major first line drug for tx of TB
What type of drug is Pyrazinamide (PZA) major first line drug for tx of TB
What type of drug is Ethambutol (EMB) major first line drug for tx of TB
What two drugs are special circumstance first line drugs for TB tx rifabutin and rifapentine
When should you avoid giving Isoniazid (INH) it is metabolized by liver avoid giving in active liver disease
What are the major s/e of Isoniazid (INH) Clinical hepatitis and fatal hepatitis, Peripheral Neuropathy
What are the major s/e of rifampin hepatotoxicity, thrombocytopenia, flu-like syndrome, rash, orange discoloration of bodily fluids (tell pt may stain cloths and contact lenses)
What are the major s/e of pyrazinamide hepatotoxicity, GI symptoms, Arthralgias/ gouty arthritis
when is pyrazinamide contraindicated contraindicated in pt suffering from gout
What are the major s/e of Ethambutol Retrobulbar neuritis (decreases visual abilities damage can be permanent),
Which of the TB first line tx is not hepatotoxic only one is ethambutol
Which fluoroquinolones can also be used to tx active TB levofloxacin, and Moxifloxacin
Which aminoglycosides are also useful in tx of active TB streptomycin (used to be first-line) Amikacin/Kanamycin, Capreomycin
What is the almost exclusive use of cycloserine tx of active TB
What are the major s/e of cycloserine CNS effects
What is Ethionamide used for tx of active TB
what are the major s/e of Ethionamide GI symptoms, Hepatotoxicity, Neurotoxicity
What are the major s/e of P-Aminosalicylic acid (PAS) hypothyroidism, GI symptoms, hepatotoxicity
Created by: smaxsmith