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WVSOM -- immunmo

WVSOM -- Combank/Kaplan -- CD/IL/Complement

QuestionAnswer
C5b-9 MAC
C5a Neutrophil chemotaxis
C3b opsonization protein
What works with C3b to opsonize bacteria? IgG
C1,C2,C3,C4 classical pathway that are involved in viral neutralization
T Cell, thymocytes, NK cells. Adhesion molecule CD2
T Cells and thymocytes, Signal transduction by TCR CD3
Coreceptor for MHC class I-restricted T cells CD8
LPS receptor on monocytes, macrophages and granulocytes CD14
Fc receptor found on NK cells, marcrophages, neutrophils for opsonization and ADCC CD16
Cell adhesion molecule in leukocytes CD18
Coreceptors for b-Cell activation CD19/21
Unknown role in B-cell activation CD20
Epstein Barr Virus receptor CD21
T cell receptor for costiulatory molecule B7 CD28
Cell-cell adhesion, binds L-selectin and found on precursors of hematopoietic cells, endothelial cells in HEV CD34
Leukocyte common antigen. critical role in receptor mediated singaling of T and B cells CD45
NK cells CD56
Coreceptor for TCR-MHC II interaction CD4
CD receptor for HIV CD4
costimulates activation of TH cells IL-1
promotoes maturaion and clonal expansion of B cells IL-1
Enhances activity of NK cells IL-1
Chemotactiacally attracts macrophages and neutrophils IL-1
Induces fever in hypothalamus IL-1
Induces synthesis of acute-phase proteins in hepatocytes IL-1 and IL-6
induces proliferation and enhances activity of antigen primed TH and CTLs IL-2
Supports growth and differentiation of hematopoietic cells IL-3
Costimulates antigen-primed B Cells IL-4
Stimulates proliferaion and differentiataion,as well as inducing class switch to IgG1 and IgE IL-4
Stimulates proliferation and differentiation and induces class switch to IgA in activated B cells IL-5
Promotes terminal differentiation into plasma cells IL-6
Stimulates Ab secrion by plasma cells IL-6
Induces differentiation into progenitor B and T cells in Lymphoid stem cells IL-7
Chemokine to indicue adherence of neutrophils to endothelium and extravasion into tissues IL-8
suppresses cytokine production by TH1 cells IL-10
Acts syunergistically with IL-2 to induce differentiaion in to CTL IL-12
Inhibits viral replication secreted by leukocytes Interferon alpha
Inhibits viral replication secreted by fibroblasts Interferon beta
Enhances activity of macrophages interferon gamma
increases expression of class I MHC molecules IFN-gamma
Induces class switch to IgG2a, blocks IL-4-induced class switch to IgE and IgG1 in proliferating B cells IFN-gamma
inhibits proliferation of TH2 cells IFN-gamma
Induces class switch to IgA TGF-Beta
Cytotoxic effect on tumor cells and induces cytokine secretion causing cachexia of chronic inflamation TNF-alpha
cytotoxic effects as well as enhancing phagocytic activity TNF-beta
Found on all nucleated cells of the body MHC I
found on all APCs MHCII
Created by: tjamrose