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Pharmacology Step 1
Question | Answer |
---|---|
What drug is useful in an acute gouty attack? What is its MOA? | Colchicine; binds to tubulin, blocks formation of microtubules and (-) phagocytosis of urate by WBCs |
What is the MOA of Tiagabine? | (-) GABA uptake by (-) GABA transporter |
What is used in the tx of methanol ingestion? | Fompeizole; inhibits alcohol dehydrogenase |
What is used to reverse acute dystonias during antipsychotic tx? | Benztropine; anticholinergic |
What drug is a nonstimulant that inhibits reuptake of NE for the tx of ADHD? | Atomoxetine |
What is the MOA of Tacrolimus? | binds to FKBP and inhibits calcineurin; prevents de-P of transcription factor NFATC |
Which oral hypoglycemia causes a disulfram-like reaction? | Chlorpropamide |
How do cells acquire resistance to multiple anti-cancer drugs? | MDR2 gene, cells overproduce cell surface glycoproteins |
What is the MOA of Bleomycin? | fragments DNA in G2 phase |
Which anti-cancer drugs work by cross-linking DNA? | alkylating agents (nitrosureas, cyclophosphamide) |
How does cytarabine work ? | pyrimidine antagonist; (-) chain elongation when AraCTP is incorporated into the chain |
Which anti-canter drugs work by intercalating into DNA? | doxorubicin, daunorubicin, dactinomycin |
Which anti-cancer drugs can cause areflexia? | vincristine, vinblastine |
Which antidepressant blocks alpha2 receptors? | Mirtazapine |
How do you treat beta-blocker toxicity? | glucagon |
What is the MOA of metronidazole? | bacterial/protozoal ferrodoxins reduce metronidazole to an active nitroderivative to (-) DNA replication and cause mutations |
Which HIV drug causes redistribution of fat to central areas? | protease inhibitors |
What anti-cancer drugs work in the G2 phase? | Bleomycin, Etoposide |