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PD and alz
| Question | alzhiemers | parkinson |
|---|---|---|
| what is it | - A type of dementia that affects memory, thinking and behaviour - Dementia: a general term for a decline in mental ability severe enough to interfere with daily life, Alzheimers is a specific disease | - **People with Parkinson's don't have enough of the chemical dopamine because some of the nerve cells that make it have stopped working.** - **a progressive neurological condition** |
| what is underlying cause | - cause of the disease is still unclear. - researchers found that people with alzheimers have an abnormal build-up of certain proteins (amyloid beta) to form plaques theory - plaqu prevent nerve cell-communicating, tangles prevent nutrient delivery | We don't yet know exactly why people get Parkinson's. Researchers think it's a combination of age, genetic, and environmental factors that cause the dopamine-producing nerve cells to die. |
| major symptoms | cognitive Memory loss Trouble completing easy tasks Difficult solving probleems Changes in mood or personalooy; - Prooblems with communication, - Confusion about places, people and events - Visual changes, such as trouble understanding images | motor The 3 main symptoms of Parkinson's are all motor symptoms. They are tremor, stiffness and slowness of movement |
| how effect the brain proogress?? | - disrupts the way electrical charges travel within cells and the activity of neurotransmitters. | - degeneration of nerve cells in the substantial nigra - lower levels of dopamine ++ |
| current conventional treatment | relive - dont slow reverse treat sleep change, behavir other conditin memantine glutamate regulators prescribed to improve cognitive regulates the activity of glutamate moderate to severe alzheimers headache, constipation, confusion, dizziness | - medication - physical activity - therapies - physiotherapy - speech and language therapy - occupational therapy - surgery e.g deep brain stimulation relieve - dont slow or revrse |
| medication | - cholinesterase inhibitors - help prevent the breakdown of acetylcholine - treat symptoms related to memory, thinking, language, judgement and other thought processes. - diff medicine diff stages nausea, vomiting, loss of appetite 💩 | ⬆ dop - dop sub, block breakdown levadopa chem building block body convert dop, occur natural |
| relevant words | beta-amyloid plaques - abnormal clusters of protein framgnet, build up between nerve cells. tau tangles - twisted strands of another protein . destroy vital cell transport system made up f protiens. where tangle - nutrients&co can no longer move thru 💀 | basal ganglia - group of deep brain nuclei respoonsible primarily for motoor control, decision making, reward & addidction (SE) substantia nigra - region of brain that produces dopamine hence control movemnt and muscle tone |
| med limit | combined mod-severe desnt clear plaque | dopa cell still die - less effective ~dyskinesia - involuntary movements ~impulsive and compulsive behaviours - iron reduce effective - nausea,vomiting, hypotension, loss of appetite, anxiety, depression, hallucinations, sleep problems |