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ANS pharm flash cards for COMLEX 1

Atenolol Use: HTN, Angina, Post MI MOA: competitively blocks Beta 1 Side effects: Bronchoconstriction, hypotension when combined with nitrates and HTN drugs, bradycardia (w/digoxin), unopposed alpha receptor stimulation with Epi/NE
Atropine Use: Bradycardia, AV block, IBS, Anticholinesterase poisoning, decreases secretions MOA: M blocker Side effects: Tachycardia, mydriasis, cycloplegia, warm, dry, flushed skin; delirium and hallucinations
Dobutamine Use: Acute Heart failure, cardiogenic shock; is an IV drug MOA: Beta 1 agonist SE: Tachycardia and arrhythmia
Edrophonium Use: Diagnose Myasthenia Gravis MOA: Cholinesterase inhibitor SE: Muscarinic effects ( miosis, salivation, etc)
Epinephrine USE: Cardiac arrest, V. fib, anaphylatic shock, asthma, COPD MOA: activates alpha and beta receptors, increasing IP3 and cAMP SE: hypertension, tachycardia, ischemia, hyperglycemia
Effects of Epi on alpha and Beta receptors aplha 1: vasoconstriction and increased BP Beta 1: increased HR, conduction, contractility Beta 2: vasodilation, decreased diastolic BP, bronchodilation
Phenoxybenzamine USE: Pheochromocytoma MOA: Alpha 1 blocker and some Alpha 2 blockade SE:Orthostatic hypotension
Phentolamine USE: Pheochromocytoma MOA: Alpha 1 and Alpha 2 antagonist SE: Hypotension
Phenylephrine USE: Nasal and ocular decongestant; drug induced hypotension, pupil dilation (w/o cycloplegia) MOA: Alpha 1 agonist SE:Rebound Nasal Congestion, HTN, HTN Crisis if given with MAOI, Vassopressor effect increased by TCA's
Pilocarpine USE: treatment of Glaucoma and dry mouth (xerostomia) MOA: M agonist SE: Miosis, blurred vision, effect increased with other cholinergic drugs, effects decreased by atopine
Pralidoxime ( 2-PAM) USE: Organophosphate poisoning MOA: Binds phosphorus of organophosphate and breaks its bond with cholinesterase
Propranolol USE:Angina, HTN, Post MI, Cardiomyopathy, benign tremor, migraine prophylaxis, thyrotoxicosis MOA: Nonselective Beta blocker SE: Bronchoconstriction, inhibits glycogenolysis, nightmares, mood depression
Pseudoephedrine USE: Nasal decongestant for allergic and viral rhinitis MOA: Increases release of NE, Alpha agonist SE:Tachycardia, increased BP, CNS stimulation
Pyridostigmine USE: Tx of Myasthenia Gravis, reversal of nondepolarizing neuromuscular blockers MOA: AChE inhibitor SE: Muscarinic effects, prolongs effects of succinylcholine
Rocuronium USE: Skeletal muscle relaxation for intubation, surgery and ECT MOA: Competitively blocks N receptors in skeletal muscle SE: Respiratory muscle paralysis and apnea
Sildenafil USE: Erectile Dysfunction MOA: Phosphodiesterase 5 inhibitor causing vasodilation in corpus cavernosum SE: Headache, nasal congestion, back pain, visual disturbances; If used with nitrates can cause reflex tachycardia, angina, myocardial ischemia, death
Succinylcholine USE: Short term skeletal muscle relaxation for intubation and surgery MOA: N receptor antagonist, causing prolonged depolarization of skeletal muscle and paralysis SE: respiratory muscle paralysis and apnea
Tamsulosin USE: BPH MOA: Alpha 1-a antagonist in prostate SE: dizziness, headache, postural hypotension
Terazosin USE: HTN, BPH MOA: Alpha 1-a antagonist SE: Hypotension, first dose syncope
Created by: erint