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Anti-protozoal

pharma

QuestionAnswer
Metronidazole trophozoites and cyst
Metronidazole MOA:- diffusion through the cell membrane reduced by flavodoxin and ferrodoxin binds to DNA cause DNA fragmentation
Metronidazole SE:- Metallic taste peripheral neuritis Disulfiram like effects (avoid alcohol)
Metronidazole FOR Giardiasis Trichomonas vaginalis ulcerative gingivitis anaerobic = P.aureginosa and Pylori
Diloxanide furoate cyst luminal
Diloxanide furoate active substance is diloxanide and stays not absorbed
Diloxanide furoate SE: Flatulence
Diloxanide furoate asymptomatic luminal infection
Paromomycin luminal aminoglycoside
Paromomycin cell membrane causing leakage
Paromomycin for E.histolytica
Chloroquine tissue trophozoites liver mainly
Chloroquine SE:- Anorexia and blurred vision
Chloroquine rare SE:- psychosis confusion seizures hypotension ECG arrhythmia impaired hearing
Chloroquine FOR: liver abscess
Emetine tissue trophozoites from ipecac
Dihydroemetine inhibit peptidyl -trna translocation .'. elongation of the polypeptide is inhibited
Emetine given subcutaneous IM
Dihydroemetine SE:- arrhythmia congestive heart failure muscle weakness hypotension
Dihydroemetine CONTRA:- pregnancy children renal disease cardiac disease
Leishmania drugs 1-Amphotericin B 2-Miltefosine 3-Sodium stibogluconate
Miltefosine for amastigotes and promastigotes
Miltefosine inhibit cytochrome C oxidase .'. apoptosis like death
Miltefosine SE: Steven Johnson's syndrome decreased kidney failure
Miltefosine contra in pregnancy
Created by: Heba666
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