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Pharm 2
Biologic Response Modifier Therapy
| Question | Answer |
|---|---|
| Which biologic response modifier is expected to stimulate the production of bone marrow cells and to shorten the recovery time after bone marrow transplantation? | Colony-stimulating factors |
| Which phrases are accurate descriptions of the role of interferons? | -Inhibit division and replication of tumor cell -Produced in the body by activated T cells and other cells during viral replication -Assist cells by producing enzymes that block viral replication and stop viral entry into healthy cells |
| Which biologic response modifiers (BRMs) are proteins that are made by cells in the body’s immune system? | -Colony-stimulating factor -Interferons -Interleukin -Keratinocyte growth factors |
| Which IFN-alfa products are used for the management of chronic hepatitis C? | -IFN-alfa-2a -IFN-alfa-2b -Peginterferon alfa-2a -Peginterferon alfa-2b |
| Which disease state would interferon-β products be used to manage? | Multiple sclerosis |
| Which IFN-alfa product is expected to have the longest elimination half-life? | Peginterferon alfa-2b |
| Which drug is administered to promote proliferation, differentiation, and migration of epithelial cells? | Palifermin |
| Which statement regarding the pharmacokinetic profile of aldesleukin is accurate? | The drug is distributed through the extracellular space. |
| Which drug is used in metastatic renal cell carcinoma and metastatic melanoma to enhance lymphocytic production and cytotoxicity? | Aldesleukin |
| Which baseline assessments would a nurse ensure have occurred before administering filgrastim therapy to a patient? | -Bowel sounds and patterns -Cardiovascular assessment, including blood pressure, heart rate, edema, and heart sounds -White blood cell count |
| A nurse teaches a patient about the administration of newly prescribed aldesleukin. Which statements by the patient indicate need for further intervention? | -"My vision might change when I am receiving aldesleukin." -"I will inject the drug into my abdomen or the back of my arm." -"Aldesleukin may change the way I taste food and discolor my tongue." |
| Which patient does a nurse determine cannot safely receive therapy with interferon-α-2b? | A 57-year-old patient with alcoholic cirrhosis |
| Which instructions would a nurse follow when administering palifermin to a patient receiving intravenous (IV) chemotherapy? | -The patient's IV line should be flushed if any heparin is present before administering palifermin. -The drug product should be protected from light when not being administered. |
| -- | -The nurse should wait at least 24 hours after chemotherapy before giving another dose of palifermin. |
| Which rationale does a nurse provide a health care provider regarding a potential drug interaction in a patient who has been prescribed aldesleukin and is currently on atenolol and lithium? | The combination of aldesleukin and atenolol can increase the patient’s risk for hypotension. |
| A nurse counsels a patient receiving aldesleukin to report any significant weight gain; sudden onset of swelling in the arms, legs, and other body parts; nasal congestion; weakness; fatigue; and nausea. | -- |
| These symptoms would be suggestive of which adverse effect? | Capillary leak syndrome |
Created by:
Lightnning54
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