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Bac, & viral Disease
Microbiology 1 final
| Question | Answer |
|---|---|
| Streptococcal Diseases | Strep throat Scarlett fever Necrotising Fascitis |
| Streptococcal disease microbe? | Streprococcus Pyrogenes Chains of Gram Pos cocci in lungs/throat ears/ respiratory problems in skin, fleash eating bacteria w/ extra toxin gene, Scarlet fever (breaks capillaries) |
| Diptheria Disease symptoms | Toxin kills epithelial cells of pharnyx, dead cells, mucus, WBC & fibers create pseudo membrane - can be fatal |
| Diptheria microbe | Corynebactrum bipheria (gram Pos) |
| Pertussis Whooping Cough symptoms | 100 day cough |
| Pertussis Whooping Cough microbe | Bordetella Pertussis, Vaccine is DTaP Diptheria, tetenus, acellular Pertusis |
| Meningococcal meningitis symptoms | gets in through res. tract, into blood vessels and cerebrospinal fluid (inflamation of mennenges) |
| Meningococcal meningitis microbe | Neisseria Menngitiois, Gram (-) neg. TREAT: antibiotic and antitoxin (neutralize poison bacteria produce) |
| Haemophilus meningitis | Haemophilus Influenza, type B; not related to the flu, Vaccine in USA 1987, 5% mortality |
| Tuberculosis microbe | Mycobacterum Tuberculosis, (acid fast, rod staining) |
| Tuberculosis symptoms | fever, blood in sputum, chest pain, night sweats, weight loss. Forms tubercles. Consumption. Kills up to a million peeps a year |
| Tuberculosis treatment | open air, Isoniazid, Ritampicin, antibiotics |
| Primary Atypical pneumonia microbe | Mycoplasma pneumoniae, 0.2 micrometers, the smallest pneumonia |
| Primary Atypical pneumonia description | occurs in healthy people, "walking pneumonia", no cell wall in a micoplasma so penicillion won't work |
| Primary Atypical pneumonia treatment | antibiotics to target ribosome Diagosis, cast test (antibodies will clump)s (tetracycline/ erythromycin) |
| Pneumococcal Pneumonia microbe | Streptococcus pneumonia (resident organism that usually doesn't cause disease) |
| Pneumococcal Pneumonia description | fluid in lungs, targets elderly & Secondarily immune compromised individuals, tens of thousands of fatalities in US every year. |
| Other pneumonia causing bacteria | Klebsiella pneumonia & Serratia marcascens: Nosocomial infections (acquired in healthcare setting) health care workers (yikes), lung infections & UTI's |
| Legionnaires Disease microbe | Legionella pneumophila (phila = like) Gram Neg, Diff to grow in lab, grows in standing water & air conditioners |
| Legionnaires Disease description | Mortality rate of 15 to 20%, first outbreak killed lots of vets, Treatment: Erythromycin |
| Q Fever Description | microbe: Coxiella Burnetti, Type: Rickettsiae (very small) causes: contact with animals |
| Psittacosis Description | Pron "sitaki" Chlamidia psittaci, mild infection, get from birds. |
| Intoxications VS infections | Food borne: Intoxication from toxins/poisons Infections from live bacteria |
| Staphylococcal food poisoning (most common after salmonella) | S. Aureus - clusters of spheres (nasal passage, throat, hair, skin; very common; fast incubation (1-6); grows well on meats, dairy, potato salad; Produces exotoxin/ enterotoxin(abdominal symptoms, nonlethal) |
| Botulims microbe | Clostridium Botulism, the most lethal bacteria on earth, Anerobic, spores, powerful nerve toxin, canned food & honey, flacid paralysis |
| Salmonellosis (all) | Salmonella genus, high incidence in US, get from poultry, eggs, mayo, fever, diarrhea, reactive arthritis |
| Typhoid fever (all) | Typhos (cloudy or smoky) Salmonella Typhi,(sewage & foods) FROM: poultry, mayo, etc SYM: bloody stool, fever, delirium. Ulcerate intestines & pass to blood. may get "reactive arthritis" Decimated populations |
| Typhoid Fever transmission | the five F's: fleas, food, feces, fomites (objects) ____ one more?? |
| Typhoid Mary | Carriers: 5% shed Salmonella Typhi, but have no symptoms. She was a cook who gave it to 28 people. |
| Shigllosis (causes 2 diseases: shigellosis & dysentery) | shigellosis: small intestine infection (watery diahhrea); Dysentary: Lg intestine (bloody stool w/cramping). dirty water, food, shellfish (veggies washed in dirty water). Severe dehydration possible, treat symptoms only. |
| Cholera | Vibro Cholerae: shellfish, oysters, or fecal contaminated water. Intense "rice water stools", dehydrate (no urine, thick blood, wrinkle skin) TRT: Tetracycline & rehydration |
| Cholera Epidemics | 7 pandemics since 1800's |
| E coli | Gm (-) NEG w/ pili for attachment, gastroenteritis, Complications: HUS (kidney failure, hemeragic colitis), DANGEROUS: E coli 0157:H7, mutates by transduction |
| Transduction | a bacterial gene is transferred to another bacterium by a virus |
| Peptic Ulcer Disease | Heleobactor Pilori, Has urase enzyme: breaks down urea in stomach (neutralizes acid) & breaks down stomach linig, DX: breath test. CONT: person to person TRT: heavy does tetracyclines for months. |
| Listeriosis | Listeria Monocytogenes, contaminated meat, milk & cheese, Affects monocytes (immune syastem), psychrotrophic |
| Psychrotrophic | Grows in refrigerator |
| microaerophile | likes a little O2 = Campylobacteriosis |
| Campylobacteriosis | On of the most common diseases in US, Diarrhea fever, cramps; contaminated poultry; sometimes fatal; COMP: Guilian Barre |
| Brucellosis | Brucella species, Get from animals, raw milk, open wounds; RARE farmers & vets; Undulant fever, TRT: Doxycycline/ Rifampin |
| Strepococcus Mutans | Plaque on teeth, 20 types of bacteria cause biofilms SYM: caries (sugar digest by bac, secrete acid)& gingivitis |
| Anthrax | Bacillus Anthraxis, Toxin producing bac., kills cells, respiratory (often fatal) 7 cutaneous |
| Tetanus | Clostridium tetani, secretes toxin that blocks muscle relaxation, anerobic, from soil, vaccine |
| DTaP | Diptheria, tetanus, pertussis |
| Gas Gangrene | Clostridium perfringens, (soil) bac. forms toxins, "gangrene" = blood flow stopped. wet gangrene ferments proteins & carbs to gas. |
| Bacteria that produce toxins: | Gangrene (clostridium perfringes), tetanus (clostridium tetani), Clostridium botulinum: botulinum, Anthrax (bacillus anthraxis),Corynebacterium diphtheriae: diptheria, Bordetella pertussis: pertussis toxin Vibrio cholerae: cholera, |
| Bubonic Plague | Versina Pestis (from pest-flea), Lungs> contagious & fatal, blood (septicemic) fatal, Boboes> purple lesions at lymph |
| Rocky Mountain spotted fever | Rickettsia Rickettsii (Ricketty tick), fever & rash, (Dox & Amox) |
| Lyme Disease | Borrelia burgdorferi (BB like Bambi), spirochete, (Dox & Amox), can result in chronic arthritis |
| Typhus Fever (not Typhoid) | Rickettsia Prowazekii, lice, |
| Difference between Typhus fever and typhoid fever | Typhus = lice borne, INFECTION (high fever) Rickettsia prowazekii. Typhoid Fever = Food poisoning, (bloody stool) INTOXICATION, Salmonella typhi, 5 f's food, fleas, feces, fomites |
| The 5 F's | Food, feces, fingers, fomites, fleas |
| Leprosy | mycobacterium leprae (like TB, eats tissue), 3 - YEAR incubation, disfiguring (lepromas), nerve damage |
| Zap it with Dap | Dapsone > leprosy, malaria, PCP (MDT, multi) |
| ABC infections | Abcess (pus filled lesion) Boil (infected hair follicle) Carbuncle (a series of connected boils) |
| Staphylcoccal infections | Staphyloccus aurus, ABC infection, the most dangerous staph, can penetrate to blood, MRSA/ VRSA Methicillin/ Vancomycin |
| Toxic Shock Syndrome | strain of SA, Makes Toxin, lacerates tissues, bloodstream, lack of O2, (tattoos, tampons) |
| Trachoma | Chlamydial Trachomas, #1 cause of preventable blindness (omas - tumors) |
| Streptococcal Diseases | Scarlett fever, Narcotizing fasciitis |
| Yaws | (raspberry) spirochete, like syphilis organism |
| UTI | E. Coli & others, pili help attach |
| Syphilis | Treponema Pallidum = spitochete, 3 stages: Chancre, rash, rumma (lesion/ CNS degrneration, sex & placenta |
| Gonorrhea | Neisseria Gonorrhoeae,n gm neg dipplococcus, |
| Chlamydial urethritis | Chlamydia Trachomatis, (urinary TRACH)#1 infectious disease (STD) (Matis, inflammations) BOTH END IN TIS |
| Influenza | Recombant RNA virus, 9-15 HN spikes (attachment/ release), Antigenic shift - major changes to flu genome RESPIRATORY |
| Parainfluenza | kids under 6, misdiagnosed as cold |
| Adenovirus | common cold (20 viruses) |
| Rhinovirus/ Corona virus | inflammation upper respiratory tract. 60% on hands. Corona, crown spike proteins |
| SARS | variant corona virus, 2003, severe pneumonia |
| RSD = resp syncytial disease | babies, viral pneumonia, syncytia = giant cell fusions |
| synagist | Immune Globulin |
| Herpes Simplex | Herpes = "to creep" infects nerves under skin, 90% exposed, type 1 mouth, type 2 |
| Provirus | Goes latent, hides, recurrent attacks under stress |
| Base Analog | Fake nucleotide (fake G) Acyclovir: anti viral |
| Kaposi's sarcoma | provirus gets in genes & mutates DNA, (MUTAGEN) |
| Chicken pox/ shingles | VZV - Herpes varicella/ Herpes zoster (girdle) not true pox. |
| Asprin | Reyes Syndrome |
| Smallpox | Variola virus 30% fatal, spread by resp droplets, huge fluid-filled vesicles, totally ERADICATED 1979, bio terrorism threat |
| Monkeypox | came to America in prairie dogs and Gambian rats. |
| Papilloma virus | HPV: herpes, provirus, warts & cervical cancer |
| measles | red w/white centers, koplik spots in mouth, cause encephalitis |
| Mumps | virus blocks parotid (saliva) glands, can affect testes (orchitis) |
| Rubella | German measeles, rash is flat, vertical transmission |
| vertical transmission | mom to fetus |
| MMR | attenuated live vaccine |
| fifth disease | 5 rash diseases, slapped cheek |
| Yellow Fever | virus, mosquito vector, fever jaundice, internal bleeding (30,000 deaths annually) |
| Jaundice | liver infection - improper breakdown of RBC or overflow of bile into blood |
| ARBOvirus | Arthropod Borne |
| Dengue Fever | RNA virus, 4 serotypes, |
| Infectious mononucleosis | EBV = Epstien Barr Virus, Herpes virus, children & young adults, spleen rupture burkitt's lymphoma (africa), |
| Hep A (acute) | A & E food & water borne, Acute lasts 2 weeks to 6 months, nausea, vomiting, jaundice, liver enlargement (all Hep have some) |
| Hep B (body fluids) | Body fluids, incubate 4-6 months, complication: liver cancer, Treat: immuunoglobulin/ interferon Can be with Hep D |
| Hep C (chronic) | STD & needles, slow but deadly, cirrhosis & lover failure, #1 reason for liver transplants |
| Viral Gastroenteritis | Rotavirus (worse, Norvirus (cruise ships) inflammation of GI, dehydration kills 600,000 kids per year |
| Lassa Fever | Rats (eating or preparing), potentially deadly hemorrhagic fever |
| Ebola virus | Filoviridae family (needle & thread) melts your organs, 50 - 90% mortallity, similar Marurgh virus, |
| HIV/ AIDS | + RNA virus, reverse transcriptase to make DNA copy & hide in DNA, destroys immune system, when T helper cells beloww 200 = AIDS |
| Rabies | Rhabdoviridae family = bullet shaped, single strand RNA, spinal cord & brain degenerate, hydrophobia, death from respiratory paralysis, Dumb and violent rabies. |
| Rabies incubation | 2 months to a year, so can get the sh |
| Polio | a pico virus, one of the smallest, contaminated food & water, paralysis, may be the next one eradicated |
| CMV Cytomegalovirus | Eyes & brain, produce serious birth defects, vertical transmission-microcephaly |
| West Nile | arbovirus, encephilitis |
| Varient CJD | Prion disease, infectious proteins that cause fatal brain diseases |
| Amoebiasis | Entamoeba Histolytica-tissue breaker, 2nd only to malaria for death. water, cysts |
| PAM Primary Amoebic Meningoenchelitis | killer amoeba, naegleria fowleri. 95% death, waterborne through nose |
| Giardiasis | most common protozoal disease in US, sewage/water, enterotest capsule on a string |
| African sleeping sickness/ Chagas disease | Trypanosomiasis, 2 different diseases, ASS = tsetse fly (brain damage)/ Chagas = kissing bug(heart damage) Killed Darwin. |
| Leishmaniasis | Rose of Jerico (congrgate, soldier in the desert get it, Baghdad boil (can be lethal) |
| Trichomoniasis | STD, Trichomonis Vaginalis, flagellate, |
| Balantidiasis | B coli, ciliate (hair-like/only path. one), cyst/ water (fecal oral)/ trophozoites |
| Toxoplasmosis | Apicomplexan from cats, rats>birds> cats Toxoplasmosa gondi (protozoa) |
| Vertical transmission TORCH | Toxoplasmosis, Other (HIV), Rubella, Cytomegaiaovirus, Herpes Simplex |
| Cryptosporidiosis | Protazoa, America> swimming pool (survives chlorination), low dose (only 30 organisms) lead to infection. Intense diarrhea |
| Apicomplexan (Plasmodium) disease | Malaria, every 3-4 days comunicate & explode cells > fever > chills during recovery |
| Know the killers | HIV, TB, Malaria, Staff, Antanoeba, hanta virus |
| Cryptococcosis | Mycosis - fungal, airborne/ bird droppings/ 25% of fungal deaths, lungs/ body cavities - treatable, but dangerous (Amphoterican) |
| Candidiasis | mycosis (fungal), Candida Albicans, vulovaginitis, oral (cottage cheese), intestinal |
| Dermotophytosis | Tinea infections, tinea capitus, tinea pedus, tinea curis |
| Histoplasmosis | Histoplasma capsulatum (encapsilated spore), lungs & spores, birds & bat droppings, |
| Blastomycosis | Blastomyces dermatitidis, lungs to skin or bones, very common in SE US. Untreated can be fatal |
| Pneumo-cystic Pneumonia (PCP) | Fungal pneumonia, kills AIDS patients, resembles both fungus & animal (protozoa) |
| Aspergillosis | Aspergillus flavus: produces aflatoxin: accute hepititis/ heptic carcinoma (corn, peanuts, wet carpet) |
| Ergot poisioning | Salem witch, fungus on cereal plants or rye, cause hallucinations, convulsions, death |