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FA Musculoskeletal

MSK pathology

What mutation causes Achondroplasia? Autosomal-dominant trait. Impaired cartilage maturation in growth plate caused by fibroblast growth factor receptor mutation (FGFR3).
Osteoporosis type I Postmenopausal; ↑ bone resorption due to ↓ height, kyphosis. estrogen levels. Estrogen replacement is controversial as prophylaxis (side effects).
Osteoporosis type II Senile osteoporosis––affects men and women > 70.
Created by: 3311979