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Micro R1 (FINALS)
Chapter 13- VIRUS, VIROIDS, AND PRIONS
| Question | Answer |
|---|---|
| a contagious fluid 100 years ago | contagium vivum fluidum |
| Latin for poison | Virus |
| He was the one who isolated Tobacco Mosaic Virus and it paved the way for chemical and structural studies on viruses | Wendell Stanley |
| Viewing of viruses is now possible because of the invention of? | Electron Microscope |
| 4 Major Characteristics and Behavior of Viruses? | ●Inert outside of living cells ● Complex aggregation of nonliving chemicals or exceptionally simple living microorganisms ● Small (filterable) ● Obligatory Intracellular Parasites |
| 4 Distinctive Features | contains a single type of nucleic acid, protein coat, Multiply inside living cells, and Cause the synthesis of specialized structures that can transfer the viral nucleic acid to other cells. |
| TRUE OR FALSE . Viruses have a few or no enzymes for metabolism. | TRUE |
| These drugs that would interfere with viral multiplication would also interfere with the functioning of the host cell and therefore are too toxic for clinical use. | ANTIVIRAL DRUGS |
| Comparison Between Viruses and Bacteria | TABLE TABLE FILL IN THE BLANNKS (YES OR NO) |
| It is the spectrum of host cells the virus can infect. | HOST RANGE |
| Theses re viruses that infect bacteria. | Bacteriophages or Phages |
| What can viruses infect? | Invertebrates, vertebrates, plants, protists, fungi, and bacteria. Able to infect specific types of cells of only one host species. |
| TRUE OR FALSE. Viruses cannot cross the host-species barrier, thus it has small host range. | FALSE |
| Virus's criteria for hosts are determined by? | requirements for its specific attachment to the host cell and cellular factors required for viral multiplication |
| The outer surface of the virus must chemically interact with specific__________ on the surface of the cell | RECEPTOR SITES |
| Bacteriophages—receptor site is??? | part of the cell wall of the host; or fimbriae and flagella |
| Animal viruses—receptor sites are on the??? | plasma membranes of the host cells |
| Using bacteriophages to treat bacterial infections—was developed in France in 1919 and used until 1979. | PHAGE THERAPY |
| Evidence suggests bacteriophages in the human microbiome play a role in maintaining health. TRUE OR FALSE. | TRUE |
| Viral Size Is determined with the aid of??? | ELECTRON MICROSOCOPY |
| Viruses length ranges from ??? | 20 to 1000 nm |
| It is a complete, fully developed, infectious viral particle composed of nucleic acid surrounded by a protein coat outside a host cell. | VIRION |
| Viruses are classified by their??? | nucleic acid and structures of their coats. |
| Viral Structures include? | Nucleic Acid. Capsid. Envelope. Capsomeres. Spikes |
| Viral genes are encoded by | either DNA or RNA—but never both |
| The genome of a virus can be single-stranded but not double-stranded. TRUE OR FALSE | FALSE. The genome of a virus can be single-stranded or double-stranded |
| Nucleic Acid Can be in several separate segments examples of this is??? | INFLUENZA VIRUS |
| It can also be linear or circular. The nucleic acid. | TRUE |
| It is a protein coat that protects the virus's nucleic acid. It accounts for most of the mass of a virus, especially of small ones. | CAPSID |
| These are carbohydrate-protein complexes that project from the surface of the envelope (present or not depending on the virus). Could function as an attachment mechanism and identification. | SPIKES |
| covers the capsid (in some viruses). Usually consists of some combination of lipids, proteins, and carbohydrates | ENVELOPE |
| —protein subunits of capsids. They could be single or several types of proteins. The arrangement of capsomeres is a characteristic of particular types of viruses. | CAPSOMERES |
| Due to this some viruses can escape antibodies; surface of this are susceptible to mutations, such that the antibodies aren’t able to react with them | VIRUS PROTEINS |
| The clumping of red blood cells due to spikes of the Influenza virus. The clumping of RBC is a phenomenon called? | Hemagglutination |
| Capsids aren’t covered by an envelope. Their capsid protects the nucleic acid from nuclease enzymes in biological fluids and promotes the virus’s attachment to susceptible host cells | NONENVELOPED VIRUSES |
| General Morphology of viruses are based on?? | Based on capsid architecture revealed through X-ray crystallography |
| Enumerate the general morphology of viruses (4). | Helical Viruses, Polyhedral Viruses, Enveloped Viruses, and Complex Viruses (Bacteriophages an Poxviruses) |
| Resemble long rods that may be rigid or flexible, Nucleic acid is found within a hollow, Cylindrical capsid that has this striking structure | HELICAL VIRUSES |
| Examples of Helical Viruses are? | Rabies and Ebola Virus |
| Many plant, animal, and bacterial viruses are in this kind of structure. Its capsid is in the shape of an icosahedron , with capsomeres of each face forming an equilateral triangle. | POLYHEDRAL VIRUSES |
| what is an ICOSAHEDRON ??? | a regular polyhedron with 20 triangular faces and 12 corners |
| Example of Polyhedral Viruses is ??? | Adenovirus and Poliovirus |
| They are are roughly spherical and the capsid is covered with an envelope. | ENVELOPED VIRUSES |
| Example of Enveloped Viruses are ??? | Enveloped Helical (Influenza virus) . Enveloped Polyhedral Viruses (Human Herpes Virus) |
| Are viruses that have a complicated structures. | COMPLEX VIRUSES |
| Example of Complex Viruses are ??? | Bacteriophages and Poxviruses |
| capsids to which additional structures are attached. The capsid (head) is polyhedral (contains the nucleic acid) and the Tail Sheath is helical. | BACTERIOPHAGES |
| Are viruses that do not contain identifiable capsids but have several coats around the nucleic acid | POXVIRUSES |
| The viral portion of the human microbiome | The Human Virome |
| Are viruses found in the same sites as the majority of bacterial microbiome??? | YES |
| This is the majority of viruses that affect human health and disease by controlling the growth of normal and pathogenic bacteria. | BACTERIOPHAGES |
| Enumerate the Phage Interaction (2) | 1. Kill the Winner 2. Kill the Competition |
| This kind of interaction by Bacteriophages kill bacterial colonizers in the body. The bacteriophage benefits by having a host for reproduction, and the human host benefits by having the bacteriophage prevent colonization by pathogens | KILL THE WINNER |
| Some bacteriophages may protect the bacterial microbiome from invasion by other bacteria vying to gain a foothold in the area. | KILL THE COMPETITON |
| Enterococcus bacteria release lytic bacteriophages, from prophages when competing enterococci are present—thus killing the competition. | KILL THE COMPETITON |
| It helps us organize and understand newly discovered viral organisms. | VIRAL TAXONOMY |
| It is a system of classification based on symptoms. | SYMPTOMATOLOGY |
| Symptomatology is the oldest classification system for Virus. TRUE OR FALSE??/ | TRUE |
| Symptomatology is convenient and is scientifically acceptable; the same virus may cause more than one disease, depending on the tissue affected. TRUE OR FALSE???? | FALSE |
| Viruses modern hierarchical system are now grouped according to??? | According to how their mRNA is produced. |
| Enumerate its modern hierarchical system and its corresponding suffix. | ● Order (-ales) ● Family (-viridae) ● Genus (-virus) |
| It is A group of viruses sharing the same genetic information and ecological niche (host range) | VIRAL SPECIES |
| Are specific epithet for viruses used??? | NO |
| Species or subspecies??? human immunodeficiency virus (HIV) | SPECIES |
| Species or subspecies??? HIV -1 | SUBSPECIES |
| He was the on to developed a classification scheme for viruses, he was the one to discover retroviruses. | DAVID BALTIMORE |
| In this classification, there are seven (7) classes indicated by Roman numerals (I-VII), and 20 families of viruses under this system. It is grouped by clusters viruses into families depending on their type of genome. | The BALTIMORE CLASSIFICATION SCHEME |
| Enumerate the seven classes under Baltimore classification scheme. | CLASS I: DOUBLE-STRANDED DNA CLASS II: SINGLE-STRANDED DNA CLASS III: DOUBLE-STRANDED RNA CLASS IV: SINGLE-STRANDED RNA, + STRAND CLASS V: SINGLE-STRANDED RNA, - STRAND CLASS VI: SINGLE-STRANDED RNA, PRODUCE DNA CLASS VII: DOUBLE-STRANDED DNA, |
| Non-enveloped Medium-sized viruses that cause various respiratory infections in humans; some cause tumors in animals. Size is (70–90 nm). Example of this is Mastedenovirus. | ADENOVIRIDAE |
| Non-enveloped. Small viruses that cause warts and cervical and anal cancer in humans. Size is (40–57 nm). Example of this virus is Papillomavirus (human wart virus) and Polyomavirus | PAPOVAVIRIDAE |
| Enveloped. Very large, complex, brick-shaped viruses that cause smallpox (variola), molluscum contagiosum (wartlike skin lesion), and cowpox. Size is (200-350 nm). Examples are Orthopoxvirus (vaccinia and smallpox viruses) and Molluscipoxvirus | POXVIRIDAE |
| Enveloped. Medium-sized viruses that cause various human diseases: fever blisters, chickenpox, shingles, and infectious mononucleosis; cause a type of human cancer called Burkitt’s lymphoma. Size is (150-200 nm). | HERPESVIRIDAE |
| Enumerate virus under Class II . What is class II? | CLASS II: SINGLE-STRANDED DNA Nonenveloped. Parvoviridae |
| This examples are in what class of virus and specifically what it is?? Simplexvirus (HHV-1 and -2) ● Varicellovirus (HHV-3) ● Lymphocryptovirus (HHV-4) ● Cytomegalovirus (HHV-5) ● Roseolovirus (HHV-6 and HHV-7) ● Rhadinovirus (HHV-8) | HERPESVIRIDAE |
| Fifth disease; anemia in patients that are immunocompromised. Size is (18-25 nm). Example of this is Human parvovirus B19. | PARVOVIRIDAE |
| Enumerate virus under Class III . What is class III? | CLASS III: DOUBLE-STRANDED RNA Nonenveloped. Reoviridae |
| Generally mild respiratory infections are transmitted by arthropods; Colorado tick fever is the best-known. Size is (60-80nm). Examples include Reovirus and Rotavirus. | REOVIRIDAE |
| Enumerate virus under Class IV . What is class IV? | CLASS IV: SINGLE-STRANDED RNA, + STRAND Nonenveloped: Picornaviridae and Caliciviridae Enveloped: Togaviridae, Flaviviridae, and Coronaviridae |
| NE. Includes the polio-, coxsackie-, and echoviruses; hand-foot-mouth virus; more than 100 rhinoviruses exist and are the most common cause of colds. Size is (28-30nm). Examples include Enterovirus, Rhinovirus (common cold virus), Hepatitis A virus is | PICORNAVIRIDAE |
| Non-Enveloped. Includes causes of gastroenteritis and hepatitis E. Size is (35-40 nm). Examples include Hepatitis E virus and Norovirus. | CALICIVIRIDAE |
| En. Includes many viruses transmitted by arthropods (Alphavirus); diseases include eastern equine encephalitis (EEE), western equine encephalitis (WEE), and chikungunya. Rubella virus is transmitted by the respiratory route. Size is 60-70 nm. | TOGAVIRIDAE |
| Enumerate virus includes under Togaviridae. (2) | Alphavirus and Rubivirus (rubella virus) |
| Can replicate in arthropods that transmit them; diseases include yellow fever, dengue, Zika, and West Nile encephalitis. Size is 40-50 nm. Examples include ● Flavivirus ● Pestivirus ● Hepatitis C virus | FLAVIVIRIDAE |
| Associated with upper respiratory tract infections and the common cold; SARS virus, MERS-CoV. Size is 80-160 nm. It includes the famous Coronavirus. | CORONAVIRIDAE |
| Enumerate viruses under Class V . What is class V? | CLASS V: SINGLE-STRANDED RNA, - STRAND One strand of RNA, Enveloped: Rhabdoviridae, Filoviridae, and Paramyxoviridae. Virusoid or Satellite RNA: Deltaviridae. Multiple Strands of RNA, Enveloped: Orthomyxoviridae, Bunyaviridae, Arenaviridae. |
| Bullet-shaped viruses with spiked envelopes; cause rabies and numerous animal diseases. Size is 70-180 nm. Examples include ● Vesiculovirus (vesicular stomatatis virus) ● Lyssavirus (rabies virus) | RHABDOVIRIDAE |
| Enveloped, helical viruses; Ebola and Marburg viruses. Size is 80-14,00 nm. Example includes Filovirus. | FILOVIRIDAE |
| Paramyxoviruses cause parainfluenza, mumps, and Newcastle disease in chickens. Size is (150-300 nm. Examples include ● Paramyxovirus ● Morbillivirus (measles virus) | PARAMYXOVIRIDAE |