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Cell Bio 3rd Lec
| Term | Definition |
|---|---|
| Germ Layers (prenatal development) | ecotderm |
| Germ Layers (prenatal development) 2 | mesoderm |
| Germ Layers (prenatal development) 3 | endoderm |
| Types of embryonic connective tissue | mesenchymal |
| Types of embryonic connective tissue 2 | muscle |
| Types of specialized connective tissue | cartilage |
| Types of specialized connective tissue 2 | bone |
| Types of specialized connective tissue 3 | blood |
| Chondroblast function | contribute greatly to fibers and ground substance to ECM after they are transformed to chondrocytes |
| chondrocyte | round to oval shape |
| chondrocyte 2 | located in lacunae |
| chondrocyte function | continue to synthesize and secrete matrix |
| types of cartilage | hyaline |
| types of cartilage 2 | elastic |
| types of cartilage 3 | fibrocartilage |
| Hyaline cartilage composition | collagen type II fibers |
| Hyaline cartilage composition 2 | perichondrium |
| Hyaline cartilage composition 3 | chondroblasts |
| Hyaline cartilage composition 4 | ECM |
| Hyaline cartilage composition 5 | chondrocytes in lacunae |
| Hyaline cartilage composition 6 | isogenic group |
| Isogenic group | group of lacunae with chondrocytes lying close to each other |
| Isogenic group 2 | all chondrocytes of this group come from one chondrocyte |
| Isogenic group 3 | each chondrocyte lies in its own lacuna |
| Hyaline cartilage functions | provide support, flexibility and resilience |
| Hyaline cartilage functions 2 | reduces friction between bony surfaces |
| Hyaline cartilage functions 3 | most abundant skeletal cartilage |
| where is hyaline cartilage located | articular: covers the ends of long bones |
| where is hyaline cartilage located 2 | costal: connects the ribs to the sternum |
| where is hyaline cartilage located 3 | respiratory: makes up larynx; reinforces air passages |
| where is hyaline cartilage located 4 | nasal: supports the nose |
| elastic cartilage composition | elastic fibers |
| elastic cartilage composition 2 | collagen type II fibers |
| elastic cartilage composition 3 | perichondrium |
| elastic cartilage composition 4 | chondroblasts |
| elastic cartilage composition 5 | chondrocytes in lacunae |
| elastic cartilage composition 6 | ECM |
| elastic cartilage composition 7 | isogenic group |
| elastic cartilage functions | provides support with more flexibility |
| elastic cartilage functions 2 | can be distorted and return to original shape without damage |
| where is elastic cartilage found | external ear |
| where is elastic cartilage found 2 | epiglottis |
| where is elastic cartilage found 3 | tip of nose |
| Fibrocartilage composition | collagen type II fibers |
| Fibrocartilage composition 2 | chondrocytes in lacunae |
| Fibrocartilage composition 3 | ECM |
| Fibrocartilage function | resists compression |
| Fibrocartilage function 2 | prevents bone to bone contact |
| Fibrocartilage function 3 | limits relative movement |
| Where is fibrocartilage found | highly compressed with great tensile strength |
| Where is fibrocartilage found 2 | found in menisci of knee and in intervertebral discs |
| Where is fibrocartilage found 3 | between pubic bones |
| Types of cartilage growth | appositional |
| Types of cartilage growth 2 | interstitial |
| Appositional growth | mesenchymal cells surrounding the cartilage in the deep part of the perichondrium differentiate into chondroblasts |
| Appositional growth 2 | occurs in mature cartilage |
| Interstitial growth | chondrocytes within the existing cartilage divide and form small groups of cells (isogenic groups), which produce matrix to become separated from each other by a thin partition of matrix |
| Appositional growth 2 | occurs mainly in immature cartilage |
| Major functions of cartilage | supporting soft tissues |
| Major functions of cartilage 2 | providing a model for the formation of most of the bones in the body |
| Major functions of cartilage 3 | providing a surface where two bones meet |
| Types of anatomical bones | long |
| Types of anatomical bones 2 | short |
| Types of anatomical bones 3 | flat |
| Types of anatomical bones 4 | irregular |
| Types of lamellar bone | compact |
| Types of lamellar bone 2 | spongy |
| Woven bone | many osteocytes and the osteoid, less the inorganic substance |
| Woven bone 2 | a lot of collagenous fibers in thick tufts |
| Woven bone 3 | in fetal life and just after birth |
| Woven bone 4 | in adult individuals, it appears local to the insertion of tendons to the bone |
| Woven bone 5 | in the skull, only in pathological states |
| Components of bone | cells |
| Components of bone 2 | ECM |
| Types of bone cells | osteogenic |
| Types of bone cells 2 | osteoblasts |
| Types of bone cells 3 | osteocytes |
| Types of bone cells 4 | osteoclasts |
| ECM composition | organic matter (osteoid) |
| ECM composition 2 | Inorganic matter (mineral) |
| Types of organic matter (osteoids) | ground substance: complex polysaccharides and glycoproteins |
| Types of organic matter (osteoids) 2 | collagen fibers |
| Types of inorganic matter (minerals) | hydroxyapatite: calcium-phosphate salts |
| Types of inorganic matter (minerals) 2 | magnesium salts |
| Types of inorganic matter (minerals) 3 | random ions |
| Osteogenic cells | stem cells that line bone and divide to produce osteoblasts |
| Osteogenic cell function | assist in fracture repair |
| Where are osteogenic cells found | inner cellular layer of periosteum and endosteum |
| Osteoblasts | immature bone cells that secrete matrix compounds (osteogenesis) |
| Osteoblasts 2 | become surrounded by calcified bone and become osteocytes |
| Osteoblast function | produce new bone |
| Osteoblast function 2 | secrete matrix compounds (osteogenesis) |
| Osteocytes | mature bone cells that maintain the bone matrix |
| Osteocytes 2 | do not divide |
| Osteocyte functions | maintain the bone matrix |
| Osteocyte functions 2 | help repair damaged bone |
| Where are osteocytes found | connected by cytoplasmic processes through canaliculi in lamellae (gap junctions) |
| Where are osteocytes found 2 | live in lacunae |
| Osteoclasts | related to macrophages |
| Osteoclasts 2 | often occur in the endosteum lining the marrow cavity |
| Osteoclast functions | dissolve bone matrix and release stored minerals (osteolysis) |
| Osteoclast functions 2 | involved in bone resorption |
| Osteoclast functions 3 | secrete acids and protein-digesting enzymes |
| Types of bone membrane | periosteum |
| Types of bone membrane 2 | endosteum |
| Periosteum | double-layered protective membrane covers all bones |
| Periosteum 2 | secured to underlying bone by Sharpey's fibers |
| periosteum composition | outer fibrous layer |
| periosteum composition 2 | inner cellular layer (osteogenic layer), which is composed of osteoblasts and osteoclasts |
| Endosteum | delicate membrane covering internal surfaces of bone |
| Osteon | the basic structural unit of mature compact bone |
| Osteon 2 | osteocytes arranged in concentric lamellae around a central canal containing blood vessels and nerves |
| Osteon 3 | aka Haversian System |
| Lamella | weight-bearing, column-like matrix tubes composed mainly of collagen |
| types of lamellae | concentric |
| types of lamellae 2 | circumferential |
| types of lamellae 3 | interstitial |
| Spongy bone (cancellous bone) composition | osteoblasts |
| Spongy bone (cancellous bone) composition 2 | osteoclasts |
| Spongy bone (cancellous bone) composition 3 | lamellae |
| Spongy bone (cancellous bone) composition 4 | canaliculus |
| Spongy bone (cancellous bone) composition 5 | osteocytes |
| Bone marrow | highly vascular substance found in the space between trabeculae |
| Types of bone marrow | red bone marrow |
| Types of bone marrow 2 | yellow bone marrow |
| Red bone marrow functions | supplies nutrients to osteocytes in trabeculae |
| Red bone marrow functions 2 | forms red and white blood cells |
| Yellow bone marrow function | stores fat |
| types of bone development (ossification/osteogenesis) | intermembranous ossificaton |
| types of bone development (ossification/osteogenesis) 2 | endochondral ossification |
| Intermembranous ossification | develop within a fibrous sheet |
| Intermembranous ossification 2 | no cartilage is needed for this process |
| Intermembranous ossification 3 | produces the flat bones of the skull and part of the clavicle |
| Endochondral ossification | begins with a hyaline cartilage model and produces most of the other bones bones of the skeleton |
| Endochondral ossification 2 | primary ossification center: in the diaphysis |
| Endochondral ossification 3 | secondary ossification center: in the epiphysis |
| Endochondral ossification stage 1 | formation of bone collar around hyaline cartilage model |
| endochondral ossification stage 2 | cavitation of the hyaline cartilage within the cartilage model |
| Endochondral ossification stage 3 | invasion of internal cavities by the periosteal bud and spongy bone formation |
| Endochondral ossification stage 4 | formation of the medullary cavity as ossification continues; appearance of secondary ossification center in the epiphyses in preparation of stage 5 |
| Endochondral ossification stage 5 | ossification of the epiphyses; when completed, hyaline cartilage remains only in the epiphyseal plates and articular cartilages |
| two directions of bone growth | length |
| two directions of bone growth 2 | width |
| Bone remodeling | the bone continues to reshape itself in a constant process of bone resorption and deposition |
| Blood supply and innervation | bone is highly vascularized, especially in regions containing red bone marrow |
| Blood supply and innervation 2 | blood vessels enter bones from the periosteum |
| Blood supply and innervation 3 | the nutrient artery and the nutrient vein supply the diaphysis of a long bone |
| Homeostasis | the balance between bone building cells (osteocytes + osteoblasts) and bone recycling cells (osteoclasts) |
| Hormone functions in bone | control and regulate growth patterns in bone by altering the rates of both osteoblast and osteoclast activity |
| types of hormones | growth hormone |
| types of hormones 2 | somatonmedin |
| types of hormones 3 | calcitonin (thyroid hormone) |
| types of hormones 4 | Parathormone (parathyroid hormone) |
| Growth hormone function | affects bone growth by stimulating the formation of another hormone |
| Growth hormone function 2 | with calcitonin, regulate and maintain normal activity at the epiphyseal plates until puberty |
| Somatomedin function | directly stimulates growth of cartilage in epiphyseal plate |
| Somatomedin function 2 | produced by the liver |
| Calcitonin (thyroid hormone) function | stimulates bone growth |
| Calcitonin (thyroid hormone) function 2 | acts to decrease the concentration of calcium in the blood |
| Calcitonin (thyroid hormone) function 3 | inhibits osteoclast activity |
| Calcitonin (thyroid hormone) function 4 | with growth hormone, regulate and maintain normal activity at the epiphyseal plates until puberty |
| Parathormone (parathyroid hormone) | acts to increase the concentration of calcium in the blood |
| Major functions of bone | support |
| Major functions of bone 2 | storage of minerals and lipids |
| Major functions of bone 3 | blood cell production |
| Major functions of bone 4 | protection |
| Major functions of bone 5 | leverage |