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Bio103
Unit 12, 13, 16
| What do nucleotides consist of? | a nitrogen base, 5 carbon sugar, and a phosphate group |
| How many bases does a nucleotide have? How many is always used? | 4 bases; 1/4 is always used |
| What alternates to form 1 backbone? | phosphate group and carbon sugar |
| Bases in nucleotides include.... | 2 purines: adenine, guanine 2 pyrimidines: thymine, cytosine |
| What is Chargaff's rule about DNA structure? | A-t, C-T (apples to trees, cars to garage |
| Why is a replication of DNA considered semiconservative? | because each "old" strand (parent strand) serves as a template for the formation of a new strand |
| In what 3 ways is RNA different from DNA? | RNA is single stranded, contains sugar ribose, and the pyrimidine uracil |
| What is the builder of proteins? | RNA |
| transcription | synthesis or copying of a strand of RNA based on the DNA templates |
| pedigrees | showing the ancestral history of an individual by tracing a particular trait back several generations |
| What are traits shown in pedigrees? | [_]= male, O= female, generations, sex, autosomal, x-linked, dominate, recessive |
| autosomal | both male and female are equally likely to be affected |
| x- linked | males are more commonly affected than females (recessive) |
| karyotype (human) | an individual chromosome composition 23 pairs= total of 46 chromosomes |
| polyploidy | presence of multiple sets of chromosomes , common in plants but lethal in humans |
| aneuploidy | abnormal presence or absence of 1 chromosome in a set |
| trisonic | condition with the addition of an extra chromosome |
| monosonic | condition when one member of the chromosomal pair is missing |
| nondisjunction | failure of homologous chromosomes to seperate |
| trisomic 21 | 3 chromosomes for chromosome pair 21 because of autosomal trisomic, has 47 chromosomes instead of 46 and also known as down syndrome |
| What does the breakage and rejoining of chromosome parts result in? | structural changes within or between chromosomes |
| duplication error | segment of the chromosome is repeated 1 or more times |
| inverted error | orientation of the chromosome segment is reversed |
| deletion breakage | loss of a part of a chromosome |
| gene therapy | a strategy that aims to replace a mutant allele with a normal allele to treat some serious genetic diseases |