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Bio Chapter 6

How Cells Utilize Energy

QuestionAnswer
There are 2 general forms of energy Kinetic and potential
Kinetic energy associated with active movement
Potential Energy Due to structure or location
Chemical Potential Energy The energy in bonds between atoms, is important form of potential energy
The first law of thermodynamics States that energy cannot be created or destroyed, but can be transfformed form one type to another
The Second law of thermodynamics States that a transfer of energy from one form to another increases the entropy
Entropy degree of disorder
If entropy increases _____ energy is available for organisms to use to promote change Less
Total energy = _______ _______ + ________ _________ Usuable, energy unusable energy
Entropy is the main component of Unusable energy
Free energy (G) is... the usuable energy,the amount of energy available to do work
In Exergonic reactions, the products have _____ free energy, therefore.... Less, Free energy is released
In Endergonic Reactions, the products have _______ free energy, so...... More, free energy must be added during the reaction
Endergonic reaction can be coupled to an ________ ______ Exergonic Reaction
Catalyst an agent that speeds up the rate of a chemical reaction without being consumed during the reaction
enzymes Protein catalysts in the living cells that increase the ratess of chemical reactions
Activation energy energy that is required to start the reaction
Active site The location where the reaction takes place
Substrate the reactants that bind the enzyme and then undergoes change
Affinity The attraction of an enzyme for a substrate
Affinity can be strong when... Enzyme binds even when a substrate is at low concentration
Affinity can be weak when.... enzyme only binds at high substrate concentration
Vmax is the maximal rate
Km is the substrate concentration where velocity is half the max
Reversible inhibitors What cells use to regulate enzyme activity
Competitive inhibitors Bind non convalently to the active site
If Km increase ----- More substrate is needed to achieve the same velocity
Non competitive inhibitors bind to a distinct regulatory site
Allosteric site a distinct regulatory site
prosthetic group a small molecule permanently attached to the enzyme
co factor an ion that temporarily binds to enzyme
co enzyme an organic molecule that participates in reaction but is unchanged
What influences enzyme structure temperature, pH, ionic conditions
metabolic pathways a series of steps where chemical reaction occur
catabolic reaction break down larger molecules into smalled ones, typically exergonic
anabolic reaction synthesizeed larger molecules, typically exergonic
Types of energy intermediate ATP or NADH, which stores broken down large molecule ex: glucose
Oxidation the removal of electrons
Reduction the addition of electrons
What reactions are coupled Reduction-oxidation (redox) reactions
Substances that have been oxidized has _____ energy Less
Substances that have been reduced has ____ energy more
Cells use _____ in redox reactions NAD+/NADH
Gene regulation involves increasing/decreasing the gene-expression
Cells integrate signals from _____ _______ their environment
Feedback inhibition a product of a pathway binds a pathway enzyme at an allosteric site
Cellular respiration is a process by which living cells obtains energy from organic molecules
Aerobic respiration Uses O2 generates CO2
The 4 metabolic pathways in aerobic respiration Glycolysis, pyruvate oxidation, citric acid cycle, oxidative phosphorylation
First stage of cellular respiration Glycolysis
In the investment phase in glycolysis glucose is invested
in the cleavage phase in glycolysis Molecules are split
in the energy liberation phase in glycolysis The molecules are freed
Inputs of glycolysis 2 NAD+, glucose, 2 atp
Outputs of glycolysis 2 molecules of pyruvate, a net of 2 ATP, 2 NADH
The second stage of cellular respiration Pyruvate oxidation
The location of the second stage of cellular respiration Mitochondrial matrix
Inputs of pyruvate oxidation 2 pyruvates, 2NAD+, Co-enzyme A
Outputs of pyruvate oxidation 2 Acetyl CO-a, 2 NADH, and 2 CO2
Third stage of cellular respiration Citric acid cycle
Inputs of the citric acid cycle 6 NAD+, 2 FAD, 2 ADP, 2 acetyl groups
the citric acid cycle goes ______ Twice
Outputs of the citric acid cycle 4 CO2, 6 NADH, 2 FADH2, 2 ATP 
Fourth stage of Cellular respiration ETC/ oxidative phosphorylation
inputs of Oxidative phosphorylation 6 CO2, 10 NADH, 2 FADH, ADP, O2
Outputs of ETC 34 ATP
ATP Synthase uses The H+ gradient to synthesize ATP
The Electron transport chain consists of a group of protein complexes and small organic molecules embedded in the inner mitochondrial matrix
The final electron acceptor Oxygen receives electrons
H+ electrochemical gradient made from some energy that is released during the movements of the electrons is used to pump
H+ gradient is a _______ Source of potential energy
The flow of H+ through the ATP synthase enzyme causes ___________ conformational changes that result in the synthesis of ATP ( from ADP + P)
Chemiosis the chemical synthesis of ATP as a result of pushing H+ across a membrane
Substrate-level phosphorylation produces ATP
NADH Oxidation contributes to the H+ electrochemical gradient used to synthesize ATP
the creation of 1 ATP requires 3-4 H+ down their gradient
Cells rarely acheive 30-34 ATP molecules/glucose because NADH is used in anabolic pathways, H+gradient is used for other purposes
The actual amount of ATP produce ______ ~25
ATP synthase a rotary machine powered by an energy source
wheb proteins and fats are broken down ______ can be used in glycolysis or the CAC
Anaerobic respiration _________ Lacks oxygen
Two ways to metabolism without oxygen Anaerobic respiration and fermentation
Fermentation Produces ATP through substrate-level phosphorylation
Anaerobic respiration uses a susbtrate other than O2 as the final electron acceptor of the ETC
Nitrate reductase Product from E.Coli in anaerobic conditions, uses Nitrite
Under anaerobic conditions NADH builds up and NAD+ decreases
_______ must be regenerated to keep glycolysis running NAD+
fermentation is ____ Lactic acid production in muscles and ethanol production in yeast
Fermentation allows the continuation of glycolysis by _______ oxidizes NADH to NAD+ 
Created by: BananaBread12
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