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Synapses

AQA A-level biology nervous system year 13

TermDefinition
Presynaptic terminal/synaptic knob End of an axon terminal & adjacent to postsynaptic terminal on the dendrite
Ligand gated channels Specialised protein channels that open or close in response to the binding of a specific ligand (substrate)
Cholinergic synapse Chemical synapse that uses the neurotransmitter acetylcholine to transmit signals between neurones
Temporal summation When multiple action potentials are generated from a single presynaptic neurone in quick succession
Spatial summation The combined effects of multiple neurotransmitters on a single postsynaptic neurone (generally from multiple presynaptic neurone)
Order of impulse transmission: 1 Action potential travels down the axon of the presynaptic neurone and opens volatge gated calcium channels allowing an influx of calcium ions
Order of impulse transmission: 2 The calcium ions bind to the synaptic vesicles causing it to release its neurotransmitters (I.e., acetylcholine) into the synapse through exocytosis
Order of impulse transmission: 3 Acetylcholine (AcE) diffuses across synaptic cleft quickly because of the short diffusion pathway and two molecules bond to the receptor sites on the cholinergic ligand gated channel causing it to open and allow in sodium ions
Order of impulse transmission: 4 This generates a new action potential in the post-synaptic neurone
Order of impulse transmission: 5 AcE hydrolase hydrolysed it into choline and acetic acid (to avoid summation) & diffuse back into the presynaptic neurone to be recycled
Order of impulse transmission: 6 ATP is used by the mitochondria to recombine the choline and acetic acid and resynthesise the AcE for future use, the ligand gated sodium channels close
Excitatory neurotransmitters Neurotransmitters that bind to specific receptors to increase the likelihood of an action potential
Inhibitory neurotransmitters Neurotransmitters that bind to specific receptors to decrease the likelihood of an action potential
Created by: Study_B
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